Genetic variability and evolutionary dynamics of atypical Papaya ringspot virus infecting Papaya.

Papaya ringspot virus biotype-P is a detrimental pathogen of economically important papaya and cucurbits worldwide. The mutation prone feature of this virus perhaps accounts for its geographical dissemination. In this study, investigations of the atypical PRSV-P strain was conducted based on phyloge...

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Autores principales:	Anam Saleem, Zahid Ali, Shyi-Dong Yeh, Wajeeha Saeed, Amna Binat Imdad, Muhammad Faheem Akbar, Richard E Goodman, Saadia Naseem
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0a431d4876de4aa2aeaff88ca7a4a900
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spelling	oai:doaj.org-article:0a431d4876de4aa2aeaff88ca7a4a9002021-12-02T20:13:43ZGenetic variability and evolutionary dynamics of atypical Papaya ringspot virus infecting Papaya.1932-620310.1371/journal.pone.0258298https://doaj.org/article/0a431d4876de4aa2aeaff88ca7a4a9002021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258298https://doaj.org/toc/1932-6203Papaya ringspot virus biotype-P is a detrimental pathogen of economically important papaya and cucurbits worldwide. The mutation prone feature of this virus perhaps accounts for its geographical dissemination. In this study, investigations of the atypical PRSV-P strain was conducted based on phylogenetic, recombination and genetic differentiation analyses considering of it's likely spread across India and Bangladesh. Full length genomic sequences of 38 PRSV isolates and 35 CP gene sequences were subjected to recombination analysis. A total of 61 recombination events were detected in aligned complete PRSV genome sequences. 3 events were detected in complete genome of PRSV strain PK whereas one was in its CP gene sequence. The PRSV-PK appeared to be recombinant of a major parent from Bangladesh. However, the genetic differentiation based on full length genomic sequences revealed less frequent gene flow between virus PRSV-PK and the population from America, India, Colombia, other Asian Countries and Australia. Whereas, frequent gene flow exists between Pakistan and Bangladesh virus populations. These results provided evidence correlating geographical position and genetic distances. We speculate that the genetic variations and evolutionary dynamics of this virus may challenge the resistance developed in papaya against PRSV and give rise to virus lineage because of its atypical emergence where geographic spread is already occurring.Anam SaleemZahid AliShyi-Dong YehWajeeha SaeedAmna Binat ImdadMuhammad Faheem AkbarRichard E GoodmanSaadia NaseemPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258298 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anam Saleem Zahid Ali Shyi-Dong Yeh Wajeeha Saeed Amna Binat Imdad Muhammad Faheem Akbar Richard E Goodman Saadia Naseem Genetic variability and evolutionary dynamics of atypical Papaya ringspot virus infecting Papaya.
description	Papaya ringspot virus biotype-P is a detrimental pathogen of economically important papaya and cucurbits worldwide. The mutation prone feature of this virus perhaps accounts for its geographical dissemination. In this study, investigations of the atypical PRSV-P strain was conducted based on phylogenetic, recombination and genetic differentiation analyses considering of it's likely spread across India and Bangladesh. Full length genomic sequences of 38 PRSV isolates and 35 CP gene sequences were subjected to recombination analysis. A total of 61 recombination events were detected in aligned complete PRSV genome sequences. 3 events were detected in complete genome of PRSV strain PK whereas one was in its CP gene sequence. The PRSV-PK appeared to be recombinant of a major parent from Bangladesh. However, the genetic differentiation based on full length genomic sequences revealed less frequent gene flow between virus PRSV-PK and the population from America, India, Colombia, other Asian Countries and Australia. Whereas, frequent gene flow exists between Pakistan and Bangladesh virus populations. These results provided evidence correlating geographical position and genetic distances. We speculate that the genetic variations and evolutionary dynamics of this virus may challenge the resistance developed in papaya against PRSV and give rise to virus lineage because of its atypical emergence where geographic spread is already occurring.
format	article
author	Anam Saleem Zahid Ali Shyi-Dong Yeh Wajeeha Saeed Amna Binat Imdad Muhammad Faheem Akbar Richard E Goodman Saadia Naseem
author_facet	Anam Saleem Zahid Ali Shyi-Dong Yeh Wajeeha Saeed Amna Binat Imdad Muhammad Faheem Akbar Richard E Goodman Saadia Naseem
author_sort	Anam Saleem
title	Genetic variability and evolutionary dynamics of atypical Papaya ringspot virus infecting Papaya.
title_short	Genetic variability and evolutionary dynamics of atypical Papaya ringspot virus infecting Papaya.
title_full	Genetic variability and evolutionary dynamics of atypical Papaya ringspot virus infecting Papaya.
title_fullStr	Genetic variability and evolutionary dynamics of atypical Papaya ringspot virus infecting Papaya.
title_full_unstemmed	Genetic variability and evolutionary dynamics of atypical Papaya ringspot virus infecting Papaya.
title_sort	genetic variability and evolutionary dynamics of atypical papaya ringspot virus infecting papaya.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0a431d4876de4aa2aeaff88ca7a4a900
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Genetic variability and evolutionary dynamics of atypical Papaya ringspot virus infecting Papaya.

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