Evaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium

Abstract Spaceflight uniquely alters the physiology of both human cells and microbial pathogens, stimulating cellular and molecular changes directly relevant to infectious disease. However, the influence of this environment on host–pathogen interactions remains poorly understood. Here we report our...

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Autores principales:	Jennifer Barrila, Shameema F. Sarker, Nicole Hansmeier, Shanshan Yang, Kristina Buss, Natalia Briones, Jin Park, Richard R. Davis, Rebecca J. Forsyth, C. Mark Ott, Kevin Sato, Cristine Kosnik, Anthony Yang, Cheryl Shimoda, Nicole Rayl, Diana Ly, Aaron Landenberger, Stephanie D. Wilson, Naoko Yamazaki, Jason Steel, Camila Montano, Rolf U. Halden, Tom Cannon, Sarah L. Castro-Wallace, Cheryl A. Nickerson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biotechnology TP248.13-248.65 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/0a444f5908f9404283b41f24e25ddf2d
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spelling	oai:doaj.org-article:0a444f5908f9404283b41f24e25ddf2d2021-12-02T13:33:10ZEvaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium10.1038/s41526-021-00136-w2373-8065https://doaj.org/article/0a444f5908f9404283b41f24e25ddf2d2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41526-021-00136-whttps://doaj.org/toc/2373-8065Abstract Spaceflight uniquely alters the physiology of both human cells and microbial pathogens, stimulating cellular and molecular changes directly relevant to infectious disease. However, the influence of this environment on host–pathogen interactions remains poorly understood. Here we report our results from the STL-IMMUNE study flown aboard Space Shuttle mission STS-131, which investigated multi-omic responses (transcriptomic, proteomic) of human intestinal epithelial cells to infection with Salmonella Typhimurium when both host and pathogen were simultaneously exposed to spaceflight. To our knowledge, this was the first in-flight infection and dual RNA-seq analysis using human cells.Jennifer BarrilaShameema F. SarkerNicole HansmeierShanshan YangKristina BussNatalia BrionesJin ParkRichard R. DavisRebecca J. ForsythC. Mark OttKevin SatoCristine KosnikAnthony YangCheryl ShimodaNicole RaylDiana LyAaron LandenbergerStephanie D. WilsonNaoko YamazakiJason SteelCamila MontanoRolf U. HaldenTom CannonSarah L. Castro-WallaceCheryl A. NickersonNature PortfolioarticleBiotechnologyTP248.13-248.65PhysiologyQP1-981ENnpj Microgravity, Vol 7, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65 Physiology QP1-981
spellingShingle	Biotechnology TP248.13-248.65 Physiology QP1-981 Jennifer Barrila Shameema F. Sarker Nicole Hansmeier Shanshan Yang Kristina Buss Natalia Briones Jin Park Richard R. Davis Rebecca J. Forsyth C. Mark Ott Kevin Sato Cristine Kosnik Anthony Yang Cheryl Shimoda Nicole Rayl Diana Ly Aaron Landenberger Stephanie D. Wilson Naoko Yamazaki Jason Steel Camila Montano Rolf U. Halden Tom Cannon Sarah L. Castro-Wallace Cheryl A. Nickerson Evaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium
description	Abstract Spaceflight uniquely alters the physiology of both human cells and microbial pathogens, stimulating cellular and molecular changes directly relevant to infectious disease. However, the influence of this environment on host–pathogen interactions remains poorly understood. Here we report our results from the STL-IMMUNE study flown aboard Space Shuttle mission STS-131, which investigated multi-omic responses (transcriptomic, proteomic) of human intestinal epithelial cells to infection with Salmonella Typhimurium when both host and pathogen were simultaneously exposed to spaceflight. To our knowledge, this was the first in-flight infection and dual RNA-seq analysis using human cells.
format	article
author	Jennifer Barrila Shameema F. Sarker Nicole Hansmeier Shanshan Yang Kristina Buss Natalia Briones Jin Park Richard R. Davis Rebecca J. Forsyth C. Mark Ott Kevin Sato Cristine Kosnik Anthony Yang Cheryl Shimoda Nicole Rayl Diana Ly Aaron Landenberger Stephanie D. Wilson Naoko Yamazaki Jason Steel Camila Montano Rolf U. Halden Tom Cannon Sarah L. Castro-Wallace Cheryl A. Nickerson
author_facet	Jennifer Barrila Shameema F. Sarker Nicole Hansmeier Shanshan Yang Kristina Buss Natalia Briones Jin Park Richard R. Davis Rebecca J. Forsyth C. Mark Ott Kevin Sato Cristine Kosnik Anthony Yang Cheryl Shimoda Nicole Rayl Diana Ly Aaron Landenberger Stephanie D. Wilson Naoko Yamazaki Jason Steel Camila Montano Rolf U. Halden Tom Cannon Sarah L. Castro-Wallace Cheryl A. Nickerson
author_sort	Jennifer Barrila
title	Evaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium
title_short	Evaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium
title_full	Evaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium
title_fullStr	Evaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium
title_full_unstemmed	Evaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium
title_sort	evaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and salmonella typhimurium
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0a444f5908f9404283b41f24e25ddf2d
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Evaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium

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