Frequencies of circulating B- and T-lymphocytes as indicators for stroke outcomes
Yanling Wang,1 Jihong Liu,1 Xuemei Wang,1 Zongjian Liu,2 Fengwu Li,1 Fenghua Chen,3 Xiaokun Geng,1 Zhili Ji,2 Huishan Du,1 Xiaoming Hu1,3 1Department of Neurology, China-America Institute of Neuroscience, 2Central Laboratory, Beijing Luhe Hospital, Capital Medical University, Beijing, People&rs...
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Dove Medical Press
2017
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oai:doaj.org-article:0a48252facc34142a4b1a7a04bc683552021-12-02T06:08:52ZFrequencies of circulating B- and T-lymphocytes as indicators for stroke outcomes1178-2021https://doaj.org/article/0a48252facc34142a4b1a7a04bc683552017-10-01T00:00:00Zhttps://www.dovepress.com/frequencies-of-circulating-b--and-t-lymphocytes--as-indicators-for-str-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yanling Wang,1 Jihong Liu,1 Xuemei Wang,1 Zongjian Liu,2 Fengwu Li,1 Fenghua Chen,3 Xiaokun Geng,1 Zhili Ji,2 Huishan Du,1 Xiaoming Hu1,3 1Department of Neurology, China-America Institute of Neuroscience, 2Central Laboratory, Beijing Luhe Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Neurology, Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Background: Stroke has high mortality and morbidity. Biomarkers are required for to predict stroke outcomes, which could help clinicians to provide rationale approaches for patient management. The dynamic changes in circulating immune cells have been reported in stroke patients and animal models of stroke.Aim: The aim of this study was to explore biomarkers to predict stroke outcomes by investigating the relationship between the frequencies of circulating immune cells and stroke outcomes.Methods: In all, 50 acute ischemic stroke (AIS) patients were enrolled. Their blood samples were collected upon hospital admission and on day 1 and day 7 after stroke, and the leukocyte subsets were analyzed by flow cytometry. The dynamic changes in some types of immune cells in the AIS course and their correlation with clinical parameters were analyzed. Blood samples from 123 age- and gender-matched healthy subjects were used as controls.Results: The proportions of T-lymphocytes and NK cells in stroke patients were significantly lower than in healthy controls. The frequencies of B- and T-lymphocytes were negatively correlated with stroke severity at onset, including neurological deficits as assessed by National Institutes of Health Stroke Scale (NIHSS), and infarct volume as measured by the diffusion-weighted images (DWIs) of magnetic resonance (MR). Logistic regression analysis showed that modified Rankin scale (mRs) scores, a score system for the long-term neurological dysfunctions, were negatively correlated with the percentage of B-lymphocytes at stroke onset.Conclusion: The proportions of B- and T-lymphocytes are associated with neurological outcomes of stroke patients and might be used as an indicator for severity and prognosis of ischemic stroke. Keywords: lymphocytes, stroke, neurological deficits, infarctWang YLiu JWang XLiu ZLi FChen FGeng XJi ZDu HHu XDove Medical Pressarticlelymphocytesstrokeneurological deficitsinfarctNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2509-2518 (2017) |
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DOAJ |
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lymphocytes stroke neurological deficits infarct Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
lymphocytes stroke neurological deficits infarct Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wang Y Liu J Wang X Liu Z Li F Chen F Geng X Ji Z Du H Hu X Frequencies of circulating B- and T-lymphocytes as indicators for stroke outcomes |
| description |
Yanling Wang,1 Jihong Liu,1 Xuemei Wang,1 Zongjian Liu,2 Fengwu Li,1 Fenghua Chen,3 Xiaokun Geng,1 Zhili Ji,2 Huishan Du,1 Xiaoming Hu1,3 1Department of Neurology, China-America Institute of Neuroscience, 2Central Laboratory, Beijing Luhe Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Neurology, Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Background: Stroke has high mortality and morbidity. Biomarkers are required for to predict stroke outcomes, which could help clinicians to provide rationale approaches for patient management. The dynamic changes in circulating immune cells have been reported in stroke patients and animal models of stroke.Aim: The aim of this study was to explore biomarkers to predict stroke outcomes by investigating the relationship between the frequencies of circulating immune cells and stroke outcomes.Methods: In all, 50 acute ischemic stroke (AIS) patients were enrolled. Their blood samples were collected upon hospital admission and on day 1 and day 7 after stroke, and the leukocyte subsets were analyzed by flow cytometry. The dynamic changes in some types of immune cells in the AIS course and their correlation with clinical parameters were analyzed. Blood samples from 123 age- and gender-matched healthy subjects were used as controls.Results: The proportions of T-lymphocytes and NK cells in stroke patients were significantly lower than in healthy controls. The frequencies of B- and T-lymphocytes were negatively correlated with stroke severity at onset, including neurological deficits as assessed by National Institutes of Health Stroke Scale (NIHSS), and infarct volume as measured by the diffusion-weighted images (DWIs) of magnetic resonance (MR). Logistic regression analysis showed that modified Rankin scale (mRs) scores, a score system for the long-term neurological dysfunctions, were negatively correlated with the percentage of B-lymphocytes at stroke onset.Conclusion: The proportions of B- and T-lymphocytes are associated with neurological outcomes of stroke patients and might be used as an indicator for severity and prognosis of ischemic stroke. Keywords: lymphocytes, stroke, neurological deficits, infarct |
| format |
article |
| author |
Wang Y Liu J Wang X Liu Z Li F Chen F Geng X Ji Z Du H Hu X |
| author_facet |
Wang Y Liu J Wang X Liu Z Li F Chen F Geng X Ji Z Du H Hu X |
| author_sort |
Wang Y |
| title |
Frequencies of circulating B- and T-lymphocytes as indicators for stroke outcomes |
| title_short |
Frequencies of circulating B- and T-lymphocytes as indicators for stroke outcomes |
| title_full |
Frequencies of circulating B- and T-lymphocytes as indicators for stroke outcomes |
| title_fullStr |
Frequencies of circulating B- and T-lymphocytes as indicators for stroke outcomes |
| title_full_unstemmed |
Frequencies of circulating B- and T-lymphocytes as indicators for stroke outcomes |
| title_sort |
frequencies of circulating b- and t-lymphocytes as indicators for stroke outcomes |
| publisher |
Dove Medical Press |
| publishDate |
2017 |
| url |
https://doaj.org/article/0a48252facc34142a4b1a7a04bc68355 |
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