Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains

Host tropism and cell entry of pathogenic coronaviruses are mediated by their envelope spike (S) proteins. Here the authors present structural analyses of trimeric MERS-CoV and SARS-CoV S proteins in pre-fusion conformation, and reveal two states of the receptor binding domain that suggest new avenu...

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Autores principales:	Yuan Yuan, Duanfang Cao, Yanfang Zhang, Jun Ma, Jianxun Qi, Qihui Wang, Guangwen Lu, Ying Wu, Jinghua Yan, Yi Shi, Xinzheng Zhang, George F. Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0a48ce79c98942e39775d23cb6720f81
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id	oai:doaj.org-article:0a48ce79c98942e39775d23cb6720f81
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spelling	oai:doaj.org-article:0a48ce79c98942e39775d23cb6720f812021-12-02T15:38:37ZCryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains10.1038/ncomms150922041-1723https://doaj.org/article/0a48ce79c98942e39775d23cb6720f812017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15092https://doaj.org/toc/2041-1723Host tropism and cell entry of pathogenic coronaviruses are mediated by their envelope spike (S) proteins. Here the authors present structural analyses of trimeric MERS-CoV and SARS-CoV S proteins in pre-fusion conformation, and reveal two states of the receptor binding domain that suggest new avenues for the generation of neutralizing antibodies.Yuan YuanDuanfang CaoYanfang ZhangJun MaJianxun QiQihui WangGuangwen LuYing WuJinghua YanYi ShiXinzheng ZhangGeorge F. GaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuan Yuan Duanfang Cao Yanfang Zhang Jun Ma Jianxun Qi Qihui Wang Guangwen Lu Ying Wu Jinghua Yan Yi Shi Xinzheng Zhang George F. Gao Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
description	Host tropism and cell entry of pathogenic coronaviruses are mediated by their envelope spike (S) proteins. Here the authors present structural analyses of trimeric MERS-CoV and SARS-CoV S proteins in pre-fusion conformation, and reveal two states of the receptor binding domain that suggest new avenues for the generation of neutralizing antibodies.
format	article
author	Yuan Yuan Duanfang Cao Yanfang Zhang Jun Ma Jianxun Qi Qihui Wang Guangwen Lu Ying Wu Jinghua Yan Yi Shi Xinzheng Zhang George F. Gao
author_facet	Yuan Yuan Duanfang Cao Yanfang Zhang Jun Ma Jianxun Qi Qihui Wang Guangwen Lu Ying Wu Jinghua Yan Yi Shi Xinzheng Zhang George F. Gao
author_sort	Yuan Yuan
title	Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
title_short	Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
title_full	Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
title_fullStr	Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
title_full_unstemmed	Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
title_sort	cryo-em structures of mers-cov and sars-cov spike glycoproteins reveal the dynamic receptor binding domains
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0a48ce79c98942e39775d23cb6720f81
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Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains

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