Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability

The conserved long noncoding RNA Chaserr is transcribed upstream of the chromatin remodeler Chd2. Here, using mouse genetics and high throughput assays, the authors show that Chaserr inhibits expression of Chd2 in cis and is required for postnatal mouse development.

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Autores principales:	Aviv Rom, Liliya Melamed, Noa Gil, Micah Jonathan Goldrich, Rotem Kadir, Matan Golan, Inbal Biton, Rotem Ben-Tov Perry, Igor Ulitsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0a4d9ce9fc714ddeae7e7b59ffc05c62
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spelling	oai:doaj.org-article:0a4d9ce9fc714ddeae7e7b59ffc05c622021-12-02T14:40:21ZRegulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability10.1038/s41467-019-13075-82041-1723https://doaj.org/article/0a4d9ce9fc714ddeae7e7b59ffc05c622019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13075-8https://doaj.org/toc/2041-1723The conserved long noncoding RNA Chaserr is transcribed upstream of the chromatin remodeler Chd2. Here, using mouse genetics and high throughput assays, the authors show that Chaserr inhibits expression of Chd2 in cis and is required for postnatal mouse development.Aviv RomLiliya MelamedNoa GilMicah Jonathan GoldrichRotem KadirMatan GolanInbal BitonRotem Ben-Tov PerryIgor UlitskyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aviv Rom Liliya Melamed Noa Gil Micah Jonathan Goldrich Rotem Kadir Matan Golan Inbal Biton Rotem Ben-Tov Perry Igor Ulitsky Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability
description	The conserved long noncoding RNA Chaserr is transcribed upstream of the chromatin remodeler Chd2. Here, using mouse genetics and high throughput assays, the authors show that Chaserr inhibits expression of Chd2 in cis and is required for postnatal mouse development.
format	article
author	Aviv Rom Liliya Melamed Noa Gil Micah Jonathan Goldrich Rotem Kadir Matan Golan Inbal Biton Rotem Ben-Tov Perry Igor Ulitsky
author_facet	Aviv Rom Liliya Melamed Noa Gil Micah Jonathan Goldrich Rotem Kadir Matan Golan Inbal Biton Rotem Ben-Tov Perry Igor Ulitsky
author_sort	Aviv Rom
title	Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability
title_short	Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability
title_full	Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability
title_fullStr	Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability
title_full_unstemmed	Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability
title_sort	regulation of chd2 expression by the chaserr long noncoding rna gene is essential for viability
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0a4d9ce9fc714ddeae7e7b59ffc05c62
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Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability

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