Comparative evaluation of tractography-based direct targeting and atlas-based indirect targeting of the ventral intermediate (Vim) nucleus in MRgFUS thalamotomy

Abstract To analyze and compare direct and indirect targeting of the Vim for MRgFUS thalamotomy. We retrospectively evaluated 21 patients who underwent unilateral MRgFUS Vim ablation and required targeting repositioning during the procedures. For each patient, in the three spatial coordinates, we re...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Federico Bruno, Alessia Catalucci, Marco Varrassi, Francesco Arrigoni, Patrizia Sucapane, Davide Cerone, Francesca Pistoia, Silvia Torlone, Emanuele Tommasino, Luca De Santis, Antonio Barile, Alessandro Ricci, Carmine Marini, Alessandra Splendiani, Carlo Masciocchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0a5163bdfeaf4794bae7b1db891c2361
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0a5163bdfeaf4794bae7b1db891c2361
record_format	dspace
spelling	oai:doaj.org-article:0a5163bdfeaf4794bae7b1db891c23612021-12-02T16:10:38ZComparative evaluation of tractography-based direct targeting and atlas-based indirect targeting of the ventral intermediate (Vim) nucleus in MRgFUS thalamotomy10.1038/s41598-021-93058-22045-2322https://doaj.org/article/0a5163bdfeaf4794bae7b1db891c23612021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93058-2https://doaj.org/toc/2045-2322Abstract To analyze and compare direct and indirect targeting of the Vim for MRgFUS thalamotomy. We retrospectively evaluated 21 patients who underwent unilateral MRgFUS Vim ablation and required targeting repositioning during the procedures. For each patient, in the three spatial coordinates, we recorded: (i) indirect coordinates; (ii) the coordinates where we clinically observed tremor reduction during the verification stage sonications; (iii) direct coordinates, measured on the dentatorubrothalamic tract (DRTT) at the after postprocessing of DTI data. The agreement between direct and indirect coordinates compared to clinically effective coordinates was evaluated through the Bland–Altman test and intraclass correlation coefficient. The median absolute percentage error was also calculated. Compared to indirect targeting, direct targeting showed inferior error values on the RL and AP coordinates (0.019 vs. 0.079 and 0.207 vs. 0.221, respectively) and higher error values on the SI coordinates (0.263 vs. 0.021). The agreement between measurements was higher for tractography along the AP and SI planes and lower along the RL planes. Indirect atlas-based targeting represents a valid approach for MRgFUS thalamotomy. The direct tractography approach is a valuable aid in assessing the possible deviation of the error in cases where no immediate clinical response is achieved.Federico BrunoAlessia CatalucciMarco VarrassiFrancesco ArrigoniPatrizia SucapaneDavide CeroneFrancesca PistoiaSilvia TorloneEmanuele TommasinoLuca De SantisAntonio BarileAlessandro RicciCarmine MariniAlessandra SplendianiCarlo MasciocchiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Federico Bruno Alessia Catalucci Marco Varrassi Francesco Arrigoni Patrizia Sucapane Davide Cerone Francesca Pistoia Silvia Torlone Emanuele Tommasino Luca De Santis Antonio Barile Alessandro Ricci Carmine Marini Alessandra Splendiani Carlo Masciocchi Comparative evaluation of tractography-based direct targeting and atlas-based indirect targeting of the ventral intermediate (Vim) nucleus in MRgFUS thalamotomy
description	Abstract To analyze and compare direct and indirect targeting of the Vim for MRgFUS thalamotomy. We retrospectively evaluated 21 patients who underwent unilateral MRgFUS Vim ablation and required targeting repositioning during the procedures. For each patient, in the three spatial coordinates, we recorded: (i) indirect coordinates; (ii) the coordinates where we clinically observed tremor reduction during the verification stage sonications; (iii) direct coordinates, measured on the dentatorubrothalamic tract (DRTT) at the after postprocessing of DTI data. The agreement between direct and indirect coordinates compared to clinically effective coordinates was evaluated through the Bland–Altman test and intraclass correlation coefficient. The median absolute percentage error was also calculated. Compared to indirect targeting, direct targeting showed inferior error values on the RL and AP coordinates (0.019 vs. 0.079 and 0.207 vs. 0.221, respectively) and higher error values on the SI coordinates (0.263 vs. 0.021). The agreement between measurements was higher for tractography along the AP and SI planes and lower along the RL planes. Indirect atlas-based targeting represents a valid approach for MRgFUS thalamotomy. The direct tractography approach is a valuable aid in assessing the possible deviation of the error in cases where no immediate clinical response is achieved.
format	article
author	Federico Bruno Alessia Catalucci Marco Varrassi Francesco Arrigoni Patrizia Sucapane Davide Cerone Francesca Pistoia Silvia Torlone Emanuele Tommasino Luca De Santis Antonio Barile Alessandro Ricci Carmine Marini Alessandra Splendiani Carlo Masciocchi
author_facet	Federico Bruno Alessia Catalucci Marco Varrassi Francesco Arrigoni Patrizia Sucapane Davide Cerone Francesca Pistoia Silvia Torlone Emanuele Tommasino Luca De Santis Antonio Barile Alessandro Ricci Carmine Marini Alessandra Splendiani Carlo Masciocchi
author_sort	Federico Bruno
title	Comparative evaluation of tractography-based direct targeting and atlas-based indirect targeting of the ventral intermediate (Vim) nucleus in MRgFUS thalamotomy
title_short	Comparative evaluation of tractography-based direct targeting and atlas-based indirect targeting of the ventral intermediate (Vim) nucleus in MRgFUS thalamotomy
title_full	Comparative evaluation of tractography-based direct targeting and atlas-based indirect targeting of the ventral intermediate (Vim) nucleus in MRgFUS thalamotomy
title_fullStr	Comparative evaluation of tractography-based direct targeting and atlas-based indirect targeting of the ventral intermediate (Vim) nucleus in MRgFUS thalamotomy
title_full_unstemmed	Comparative evaluation of tractography-based direct targeting and atlas-based indirect targeting of the ventral intermediate (Vim) nucleus in MRgFUS thalamotomy
title_sort	comparative evaluation of tractography-based direct targeting and atlas-based indirect targeting of the ventral intermediate (vim) nucleus in mrgfus thalamotomy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0a5163bdfeaf4794bae7b1db891c2361
work_keys_str_mv	AT federicobruno comparativeevaluationoftractographybaseddirecttargetingandatlasbasedindirecttargetingoftheventralintermediatevimnucleusinmrgfusthalamotomy AT alessiacatalucci comparativeevaluationoftractographybaseddirecttargetingandatlasbasedindirecttargetingoftheventralintermediatevimnucleusinmrgfusthalamotomy AT marcovarrassi comparativeevaluationoftractographybaseddirecttargetingandatlasbasedindirecttargetingoftheventralintermediatevimnucleusinmrgfusthalamotomy AT francescoarrigoni comparativeevaluationoftractographybaseddirecttargetingandatlasbasedindirecttargetingoftheventralintermediatevimnucleusinmrgfusthalamotomy AT patriziasucapane comparativeevaluationoftractographybaseddirecttargetingandatlasbasedindirecttargetingoftheventralintermediatevimnucleusinmrgfusthalamotomy AT davidecerone comparativeevaluationoftractographybaseddirecttargetingandatlasbasedindirecttargetingoftheventralintermediatevimnucleusinmrgfusthalamotomy AT francescapistoia comparativeevaluationoftractographybaseddirecttargetingandatlasbasedindirecttargetingoftheventralintermediatevimnucleusinmrgfusthalamotomy AT silviatorlone comparativeevaluationoftractographybaseddirecttargetingandatlasbasedindirecttargetingoftheventralintermediatevimnucleusinmrgfusthalamotomy AT emanueletommasino comparativeevaluationoftractographybaseddirecttargetingandatlasbasedindirecttargetingoftheventralintermediatevimnucleusinmrgfusthalamotomy AT lucadesantis comparativeevaluationoftractographybaseddirecttargetingandatlasbasedindirecttargetingoftheventralintermediatevimnucleusinmrgfusthalamotomy AT antoniobarile comparativeevaluationoftractographybaseddirecttargetingandatlasbasedindirecttargetingoftheventralintermediatevimnucleusinmrgfusthalamotomy AT alessandroricci comparativeevaluationoftractographybaseddirecttargetingandatlasbasedindirecttargetingoftheventralintermediatevimnucleusinmrgfusthalamotomy AT carminemarini comparativeevaluationoftractographybaseddirecttargetingandatlasbasedindirecttargetingoftheventralintermediatevimnucleusinmrgfusthalamotomy AT alessandrasplendiani comparativeevaluationoftractographybaseddirecttargetingandatlasbasedindirecttargetingoftheventralintermediatevimnucleusinmrgfusthalamotomy AT carlomasciocchi comparativeevaluationoftractographybaseddirecttargetingandatlasbasedindirecttargetingoftheventralintermediatevimnucleusinmrgfusthalamotomy
_version_	1718384392153333760

Comparative evaluation of tractography-based direct targeting and atlas-based indirect targeting of the ventral intermediate (Vim) nucleus in MRgFUS thalamotomy

Ejemplares similares