A single arm trial using passive simulated jogging for blunting acute hyperglycemia

Abstract Glycemic fluctuations increase oxidative stress, promote endothelial dysfunction and cardiovascular disease. Reducing glycemic fluctuations is beneficial. We previously reported that a portable motorized passive simulated jogging device, (JD) reduces 24 h glycemic indices in type 2 and non-...

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Autores principales:	Jose A. Adams, Jose R. Lopez, Veronica Banderas, Marvin A. Sackner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0a53d74f7faa4e7c813cd0f2b4cdacdb
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spelling	oai:doaj.org-article:0a53d74f7faa4e7c813cd0f2b4cdacdb2021-12-02T11:39:33ZA single arm trial using passive simulated jogging for blunting acute hyperglycemia10.1038/s41598-021-85579-72045-2322https://doaj.org/article/0a53d74f7faa4e7c813cd0f2b4cdacdb2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85579-7https://doaj.org/toc/2045-2322Abstract Glycemic fluctuations increase oxidative stress, promote endothelial dysfunction and cardiovascular disease. Reducing glycemic fluctuations is beneficial. We previously reported that a portable motorized passive simulated jogging device, (JD) reduces 24 h glycemic indices in type 2 and non-diabetic subjects. This study evaluates effectiveness and feasibility of JD in blunting large glycemic fluctuation induced by an oral glucose tolerance test (OGTT). The study was performed in 10 adult participants mean age 41.3 ± 13.5 year using interstitial glucose monitor (IG). Each participant fasted for 8 h. followed by an OGTT (Pre-JD), thereafter JD was used for 90 min per day for 7 days, without change to diet or activities of daily living. A repeat OGTT (Post-JD) was performed after completion. The integrated area under the curve (iAUC2h–4h) was computed for the OGTT Pre-JD and Post-JD. Seven days of JD blunted the glucose fluctuation produced by OGTT. JD decreased AUC2h by 17 ± 4.7% and iAUC4h by 15 ± 5.9% (p < 0.03). In healthy mostly obese participants 7 days of JD blunts the hyperglycemic response produced by an OGTT. JD may be an adjunct to current glycemic management, it can be applied in different postures for those who cannot (due to physical or cognitive limitations) or will not exercise. Trial registration: ClinicalTrials.gov NCT03550105 (08-06-2018).Jose A. AdamsJose R. LopezVeronica BanderasMarvin A. SacknerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jose A. Adams Jose R. Lopez Veronica Banderas Marvin A. Sackner A single arm trial using passive simulated jogging for blunting acute hyperglycemia
description	Abstract Glycemic fluctuations increase oxidative stress, promote endothelial dysfunction and cardiovascular disease. Reducing glycemic fluctuations is beneficial. We previously reported that a portable motorized passive simulated jogging device, (JD) reduces 24 h glycemic indices in type 2 and non-diabetic subjects. This study evaluates effectiveness and feasibility of JD in blunting large glycemic fluctuation induced by an oral glucose tolerance test (OGTT). The study was performed in 10 adult participants mean age 41.3 ± 13.5 year using interstitial glucose monitor (IG). Each participant fasted for 8 h. followed by an OGTT (Pre-JD), thereafter JD was used for 90 min per day for 7 days, without change to diet or activities of daily living. A repeat OGTT (Post-JD) was performed after completion. The integrated area under the curve (iAUC2h–4h) was computed for the OGTT Pre-JD and Post-JD. Seven days of JD blunted the glucose fluctuation produced by OGTT. JD decreased AUC2h by 17 ± 4.7% and iAUC4h by 15 ± 5.9% (p < 0.03). In healthy mostly obese participants 7 days of JD blunts the hyperglycemic response produced by an OGTT. JD may be an adjunct to current glycemic management, it can be applied in different postures for those who cannot (due to physical or cognitive limitations) or will not exercise. Trial registration: ClinicalTrials.gov NCT03550105 (08-06-2018).
format	article
author	Jose A. Adams Jose R. Lopez Veronica Banderas Marvin A. Sackner
author_facet	Jose A. Adams Jose R. Lopez Veronica Banderas Marvin A. Sackner
author_sort	Jose A. Adams
title	A single arm trial using passive simulated jogging for blunting acute hyperglycemia
title_short	A single arm trial using passive simulated jogging for blunting acute hyperglycemia
title_full	A single arm trial using passive simulated jogging for blunting acute hyperglycemia
title_fullStr	A single arm trial using passive simulated jogging for blunting acute hyperglycemia
title_full_unstemmed	A single arm trial using passive simulated jogging for blunting acute hyperglycemia
title_sort	single arm trial using passive simulated jogging for blunting acute hyperglycemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0a53d74f7faa4e7c813cd0f2b4cdacdb
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A single arm trial using passive simulated jogging for blunting acute hyperglycemia

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