Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation

T regulatory (Treg) cells can differentiate into effector Treg (eTreg) cells that might be functional in inflammatory diseases. Using RNA sequencing and epigenetic profiling, the authors show that eTreg signatures in juvenile idiopathic arthritis joints are similar to tumour microenvironment (TME) T...

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Autores principales:	Gerdien Mijnheer, Lisanne Lutter, Michal Mokry, Marlot van der Wal, Rianne Scholman, Veerle Fleskens, Aridaman Pandit, Weiyang Tao, Mark Wekking, Stephin Vervoort, Ceri Roberts, Alessandra Petrelli, Janneke G. C. Peeters, Marthe Knijff, Sytze de Roock, Sebastiaan Vastert, Leonie S. Taams, Jorg van Loosdregt, Femke van Wijk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0a5628b633d646d0b5877f5920381df7
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spelling	oai:doaj.org-article:0a5628b633d646d0b5877f5920381df72021-12-02T17:02:20ZConserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation10.1038/s41467-021-22975-72041-1723https://doaj.org/article/0a5628b633d646d0b5877f5920381df72021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22975-7https://doaj.org/toc/2041-1723T regulatory (Treg) cells can differentiate into effector Treg (eTreg) cells that might be functional in inflammatory diseases. Using RNA sequencing and epigenetic profiling, the authors show that eTreg signatures in juvenile idiopathic arthritis joints are similar to tumour microenvironment (TME) Treg cells and are affected by tissue-specific epigenetic regulation.Gerdien MijnheerLisanne LutterMichal MokryMarlot van der WalRianne ScholmanVeerle FleskensAridaman PanditWeiyang TaoMark WekkingStephin VervoortCeri RobertsAlessandra PetrelliJanneke G. C. PeetersMarthe KnijffSytze de RoockSebastiaan VastertLeonie S. TaamsJorg van LoosdregtFemke van WijkNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gerdien Mijnheer Lisanne Lutter Michal Mokry Marlot van der Wal Rianne Scholman Veerle Fleskens Aridaman Pandit Weiyang Tao Mark Wekking Stephin Vervoort Ceri Roberts Alessandra Petrelli Janneke G. C. Peeters Marthe Knijff Sytze de Roock Sebastiaan Vastert Leonie S. Taams Jorg van Loosdregt Femke van Wijk Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation
description	T regulatory (Treg) cells can differentiate into effector Treg (eTreg) cells that might be functional in inflammatory diseases. Using RNA sequencing and epigenetic profiling, the authors show that eTreg signatures in juvenile idiopathic arthritis joints are similar to tumour microenvironment (TME) Treg cells and are affected by tissue-specific epigenetic regulation.
format	article
author	Gerdien Mijnheer Lisanne Lutter Michal Mokry Marlot van der Wal Rianne Scholman Veerle Fleskens Aridaman Pandit Weiyang Tao Mark Wekking Stephin Vervoort Ceri Roberts Alessandra Petrelli Janneke G. C. Peeters Marthe Knijff Sytze de Roock Sebastiaan Vastert Leonie S. Taams Jorg van Loosdregt Femke van Wijk
author_facet	Gerdien Mijnheer Lisanne Lutter Michal Mokry Marlot van der Wal Rianne Scholman Veerle Fleskens Aridaman Pandit Weiyang Tao Mark Wekking Stephin Vervoort Ceri Roberts Alessandra Petrelli Janneke G. C. Peeters Marthe Knijff Sytze de Roock Sebastiaan Vastert Leonie S. Taams Jorg van Loosdregt Femke van Wijk
author_sort	Gerdien Mijnheer
title	Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation
title_short	Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation
title_full	Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation
title_fullStr	Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation
title_full_unstemmed	Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation
title_sort	conserved human effector treg cell transcriptomic and epigenetic signature in arthritic joint inflammation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0a5628b633d646d0b5877f5920381df7
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Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation

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