MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy

Abstract Currently, mesenchymal stem/stromal stem cell (MSC) therapy has become a promising option for accelerating cutaneous wound healing. In vivo reports have outlined the robust competences of MSCs to offer a solid milieu by inhibition of inflammatory reactions, which in turn, enables skin regen...

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Autores principales:	Faroogh Marofi, Kozlitina Iuliia Alexandrovna, Ria Margiana, Mahta Bahramali, Wanich Suksatan, Walid Kamal Abdelbasset, Supat Chupradit, Maryam Nasimi, Marwah Suliman Maashi
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Mesenchymal stem/stromal stem cell (MSC) Cutaneous wounds Exosome Paracrine factors Differentiation Medicine (General) R5-920 Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/0a571669361849f1b7f26db79aea7ed5
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spelling	oai:doaj.org-article:0a571669361849f1b7f26db79aea7ed52021-12-05T12:05:45ZMSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy10.1186/s13287-021-02662-61757-6512https://doaj.org/article/0a571669361849f1b7f26db79aea7ed52021-12-01T00:00:00Zhttps://doi.org/10.1186/s13287-021-02662-6https://doaj.org/toc/1757-6512Abstract Currently, mesenchymal stem/stromal stem cell (MSC) therapy has become a promising option for accelerating cutaneous wound healing. In vivo reports have outlined the robust competences of MSCs to offer a solid milieu by inhibition of inflammatory reactions, which in turn, enables skin regeneration. Further, due to their great potential to stimulate angiogenesis and also facilitate matrix remodeling, MSCs hold substantial potential as future therapeutic strategies in this context. The MSCs-induced wound healing is thought to mainly rely on the secretion of a myriad of paracrine factors in addition to their direct differentiation to skin-resident cells. Besides, MSCs-derived exosomes as nanoscale and closed membrane vesicles have recently been suggested as an effective and cell-free approach to support skin regeneration, circumventing the concerns respecting direct application of MSCs. The MSCs-derived exosomes comprise molecular components including lipid, proteins, DNA, microRNA, and also mRNA, which target molecular pathways and also biological activities in recipient cells (e.g., endothelial cell, keratinocyte, and fibroblast). The secreted exosome modifies macrophage activation, stimulates angiogenesis, and instigates keratinocytes and dermal fibroblast proliferations as well as migrations concurrently regulate inherent potential of myofibroblast for adjustment of turnover of the ECM. In the present review, we will focus on the recent findings concerning the application of MSCs and their derivative exosome to support wound healing and skin regeneration, with special focus on last decade in vivo reports.Faroogh MarofiKozlitina Iuliia AlexandrovnaRia MargianaMahta BahramaliWanich SuksatanWalid Kamal AbdelbassetSupat ChupraditMaryam NasimiMarwah Suliman MaashiBMCarticleMesenchymal stem/stromal stem cell (MSC)Cutaneous woundsExosomeParacrine factorsDifferentiationMedicine (General)R5-920BiochemistryQD415-436ENStem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mesenchymal stem/stromal stem cell (MSC) Cutaneous wounds Exosome Paracrine factors Differentiation Medicine (General) R5-920 Biochemistry QD415-436
spellingShingle	Mesenchymal stem/stromal stem cell (MSC) Cutaneous wounds Exosome Paracrine factors Differentiation Medicine (General) R5-920 Biochemistry QD415-436 Faroogh Marofi Kozlitina Iuliia Alexandrovna Ria Margiana Mahta Bahramali Wanich Suksatan Walid Kamal Abdelbasset Supat Chupradit Maryam Nasimi Marwah Suliman Maashi MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy
description	Abstract Currently, mesenchymal stem/stromal stem cell (MSC) therapy has become a promising option for accelerating cutaneous wound healing. In vivo reports have outlined the robust competences of MSCs to offer a solid milieu by inhibition of inflammatory reactions, which in turn, enables skin regeneration. Further, due to their great potential to stimulate angiogenesis and also facilitate matrix remodeling, MSCs hold substantial potential as future therapeutic strategies in this context. The MSCs-induced wound healing is thought to mainly rely on the secretion of a myriad of paracrine factors in addition to their direct differentiation to skin-resident cells. Besides, MSCs-derived exosomes as nanoscale and closed membrane vesicles have recently been suggested as an effective and cell-free approach to support skin regeneration, circumventing the concerns respecting direct application of MSCs. The MSCs-derived exosomes comprise molecular components including lipid, proteins, DNA, microRNA, and also mRNA, which target molecular pathways and also biological activities in recipient cells (e.g., endothelial cell, keratinocyte, and fibroblast). The secreted exosome modifies macrophage activation, stimulates angiogenesis, and instigates keratinocytes and dermal fibroblast proliferations as well as migrations concurrently regulate inherent potential of myofibroblast for adjustment of turnover of the ECM. In the present review, we will focus on the recent findings concerning the application of MSCs and their derivative exosome to support wound healing and skin regeneration, with special focus on last decade in vivo reports.
format	article
author	Faroogh Marofi Kozlitina Iuliia Alexandrovna Ria Margiana Mahta Bahramali Wanich Suksatan Walid Kamal Abdelbasset Supat Chupradit Maryam Nasimi Marwah Suliman Maashi
author_facet	Faroogh Marofi Kozlitina Iuliia Alexandrovna Ria Margiana Mahta Bahramali Wanich Suksatan Walid Kamal Abdelbasset Supat Chupradit Maryam Nasimi Marwah Suliman Maashi
author_sort	Faroogh Marofi
title	MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy
title_short	MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy
title_full	MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy
title_fullStr	MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy
title_full_unstemmed	MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy
title_sort	mscs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy
publisher	BMC
publishDate	2021
url	https://doaj.org/article/0a571669361849f1b7f26db79aea7ed5
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MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy

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