Association of Microvasculature and Macular Sensitivity in Idiopathic Macular Epiretinal Membrane: Using OCT Angiography and Microperimetry

Purpose: To investigate the correlation between retinal capillary structure and macular function in patients with idiopathic epiretinal membrane (iERM) by using optical coherence tomography angiography (OCTA) and microperimetry.Methods: This retrospective and observational study included 30 idiopath...

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Autores principales:	Jingyang Feng, Xiaotong Yang, Mengqiao Xu, Yuwei Wang, Xiang Shi, Yumeng Zhang, Peirong Huang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	microperimetry epiretinal membrane vessel density prognostic factors OCT angiography Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0a58b5cc52e449a4af4713b255e7bcad
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spelling	oai:doaj.org-article:0a58b5cc52e449a4af4713b255e7bcad2021-11-16T06:20:00ZAssociation of Microvasculature and Macular Sensitivity in Idiopathic Macular Epiretinal Membrane: Using OCT Angiography and Microperimetry2296-858X10.3389/fmed.2021.655013https://doaj.org/article/0a58b5cc52e449a4af4713b255e7bcad2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.655013/fullhttps://doaj.org/toc/2296-858XPurpose: To investigate the correlation between retinal capillary structure and macular function in patients with idiopathic epiretinal membrane (iERM) by using optical coherence tomography angiography (OCTA) and microperimetry.Methods: This retrospective and observational study included 30 idiopathic ERM eyes of 30 consecutive patients. OCTA was performed to evaluate macular microvasculature including the superficial capillary plexus, deep capillary plexus, and foveal avascular zone. Best corrected visual acuity (BCVA) and microperimetry were measured at baseline and 3 months after surgery. Associations between macular microvasculature and visual function were assessed.Results: Visual function including BCVA and macular sensitivity improved significantly at 3 months post-operatively (p < 0.001). At baseline, BCVA was positively correlated with foveal or parafoveal sensitivities and negatively correlated with central foveal thickness (p < 0.05). Pre-operative foveal sensitivity was significantly correlated with the vessel density of foveal or parafoveal superficial capillary plexus (p < 0.05). A multiple regression model revealed that pre-operative vessel density of foveal deep capillary plexus was an independent positive prognostic factor for post-operative BCVA (B = −0.020 ± 0.006, p = 0.006) and macular sensitivity (B = 0.200 ± 0.081, p = 0.027).Conclusion: Integrated evaluation of iERM by using OCTA and microperimetry shows an association between microvasculature and macular sensitivity. Pre-operative vessel density of foveal deep capillary plexus assessed by OCTA may be a potentially valuable prognostic factor for iERM surgery.Jingyang FengJingyang FengJingyang FengJingyang FengXiaotong YangXiaotong YangMengqiao XuYuwei WangXiang ShiYumeng ZhangPeirong HuangPeirong HuangPeirong HuangPeirong HuangFrontiers Media S.A.articlemicroperimetryepiretinal membranevessel densityprognostic factorsOCT angiographyMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microperimetry epiretinal membrane vessel density prognostic factors OCT angiography Medicine (General) R5-920
spellingShingle	microperimetry epiretinal membrane vessel density prognostic factors OCT angiography Medicine (General) R5-920 Jingyang Feng Jingyang Feng Jingyang Feng Jingyang Feng Xiaotong Yang Xiaotong Yang Mengqiao Xu Yuwei Wang Xiang Shi Yumeng Zhang Peirong Huang Peirong Huang Peirong Huang Peirong Huang Association of Microvasculature and Macular Sensitivity in Idiopathic Macular Epiretinal Membrane: Using OCT Angiography and Microperimetry
description	Purpose: To investigate the correlation between retinal capillary structure and macular function in patients with idiopathic epiretinal membrane (iERM) by using optical coherence tomography angiography (OCTA) and microperimetry.Methods: This retrospective and observational study included 30 idiopathic ERM eyes of 30 consecutive patients. OCTA was performed to evaluate macular microvasculature including the superficial capillary plexus, deep capillary plexus, and foveal avascular zone. Best corrected visual acuity (BCVA) and microperimetry were measured at baseline and 3 months after surgery. Associations between macular microvasculature and visual function were assessed.Results: Visual function including BCVA and macular sensitivity improved significantly at 3 months post-operatively (p < 0.001). At baseline, BCVA was positively correlated with foveal or parafoveal sensitivities and negatively correlated with central foveal thickness (p < 0.05). Pre-operative foveal sensitivity was significantly correlated with the vessel density of foveal or parafoveal superficial capillary plexus (p < 0.05). A multiple regression model revealed that pre-operative vessel density of foveal deep capillary plexus was an independent positive prognostic factor for post-operative BCVA (B = −0.020 ± 0.006, p = 0.006) and macular sensitivity (B = 0.200 ± 0.081, p = 0.027).Conclusion: Integrated evaluation of iERM by using OCTA and microperimetry shows an association between microvasculature and macular sensitivity. Pre-operative vessel density of foveal deep capillary plexus assessed by OCTA may be a potentially valuable prognostic factor for iERM surgery.
format	article
author	Jingyang Feng Jingyang Feng Jingyang Feng Jingyang Feng Xiaotong Yang Xiaotong Yang Mengqiao Xu Yuwei Wang Xiang Shi Yumeng Zhang Peirong Huang Peirong Huang Peirong Huang Peirong Huang
author_facet	Jingyang Feng Jingyang Feng Jingyang Feng Jingyang Feng Xiaotong Yang Xiaotong Yang Mengqiao Xu Yuwei Wang Xiang Shi Yumeng Zhang Peirong Huang Peirong Huang Peirong Huang Peirong Huang
author_sort	Jingyang Feng
title	Association of Microvasculature and Macular Sensitivity in Idiopathic Macular Epiretinal Membrane: Using OCT Angiography and Microperimetry
title_short	Association of Microvasculature and Macular Sensitivity in Idiopathic Macular Epiretinal Membrane: Using OCT Angiography and Microperimetry
title_full	Association of Microvasculature and Macular Sensitivity in Idiopathic Macular Epiretinal Membrane: Using OCT Angiography and Microperimetry
title_fullStr	Association of Microvasculature and Macular Sensitivity in Idiopathic Macular Epiretinal Membrane: Using OCT Angiography and Microperimetry
title_full_unstemmed	Association of Microvasculature and Macular Sensitivity in Idiopathic Macular Epiretinal Membrane: Using OCT Angiography and Microperimetry
title_sort	association of microvasculature and macular sensitivity in idiopathic macular epiretinal membrane: using oct angiography and microperimetry
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/0a58b5cc52e449a4af4713b255e7bcad
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Association of Microvasculature and Macular Sensitivity in Idiopathic Macular Epiretinal Membrane: Using OCT Angiography and Microperimetry

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