A Novel Zein-Based Composite Nanoparticles for Improving Bioaccessibility and Anti-Inflammatory Activity of Resveratrol

A microbial transglutaminase-induced cross-linked sodium caseinate (MSC) was used to stabilize zein nanoparticles, and the study was to investigate whether zein-MSC nanoparticles (zein-MSC NPs) can be used as an encapsulation carrier for resveratrol. A group of resveratrol-loaded zein-MSC nanopartic...

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Autores principales:	Jiaping Liu, Yaqiong Zhang, Wenwen Liu, Boyan Gao, Liangli (Lucy) Yu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	zein cross-linked sodium caseinate resveratrol nanoparticles bioaccessibility anti-inflammatory activity Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/0a5b0a3c84fa4fd9ac27eeb54b37465b
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spelling	oai:doaj.org-article:0a5b0a3c84fa4fd9ac27eeb54b37465b2021-11-25T17:35:29ZA Novel Zein-Based Composite Nanoparticles for Improving Bioaccessibility and Anti-Inflammatory Activity of Resveratrol10.3390/foods101127732304-8158https://doaj.org/article/0a5b0a3c84fa4fd9ac27eeb54b37465b2021-11-01T00:00:00Zhttps://www.mdpi.com/2304-8158/10/11/2773https://doaj.org/toc/2304-8158A microbial transglutaminase-induced cross-linked sodium caseinate (MSC) was used to stabilize zein nanoparticles, and the study was to investigate whether zein-MSC nanoparticles (zein-MSC NPs) can be used as an encapsulation carrier for resveratrol. A group of resveratrol-loaded zein-MSC nanoparticles (Res-zein-MSC NPs) with varying zein to Res mass ratios was first prepared. The particle sizes and zeta-potentials were in the ranges from 215.00 to 225.00 nm and from −29.00 to −31.00 mV. The encapsulation efficiency (EE) of Res was also influenced by the zein to Res mass ratio, and the encapsulated Res existed in an amorphous form. The major interactions between Res and zein-MSC NPs were hydrogen bonding and hydrophobic interaction. Furthermore, compared with free Res, the photo-stability and bioaccessibility of Res-zein-MSC NPs were significantly improved. The cellular studies also showed that Res-zein-MSC NPs exhibited lower cytotoxicity and desirable anti-inflammatory activity.Jiaping LiuYaqiong ZhangWenwen LiuBoyan GaoLiangli (Lucy) YuMDPI AGarticlezeincross-linked sodium caseinateresveratrolnanoparticlesbioaccessibilityanti-inflammatory activityChemical technologyTP1-1185ENFoods, Vol 10, Iss 2773, p 2773 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	zein cross-linked sodium caseinate resveratrol nanoparticles bioaccessibility anti-inflammatory activity Chemical technology TP1-1185
spellingShingle	zein cross-linked sodium caseinate resveratrol nanoparticles bioaccessibility anti-inflammatory activity Chemical technology TP1-1185 Jiaping Liu Yaqiong Zhang Wenwen Liu Boyan Gao Liangli (Lucy) Yu A Novel Zein-Based Composite Nanoparticles for Improving Bioaccessibility and Anti-Inflammatory Activity of Resveratrol
description	A microbial transglutaminase-induced cross-linked sodium caseinate (MSC) was used to stabilize zein nanoparticles, and the study was to investigate whether zein-MSC nanoparticles (zein-MSC NPs) can be used as an encapsulation carrier for resveratrol. A group of resveratrol-loaded zein-MSC nanoparticles (Res-zein-MSC NPs) with varying zein to Res mass ratios was first prepared. The particle sizes and zeta-potentials were in the ranges from 215.00 to 225.00 nm and from −29.00 to −31.00 mV. The encapsulation efficiency (EE) of Res was also influenced by the zein to Res mass ratio, and the encapsulated Res existed in an amorphous form. The major interactions between Res and zein-MSC NPs were hydrogen bonding and hydrophobic interaction. Furthermore, compared with free Res, the photo-stability and bioaccessibility of Res-zein-MSC NPs were significantly improved. The cellular studies also showed that Res-zein-MSC NPs exhibited lower cytotoxicity and desirable anti-inflammatory activity.
format	article
author	Jiaping Liu Yaqiong Zhang Wenwen Liu Boyan Gao Liangli (Lucy) Yu
author_facet	Jiaping Liu Yaqiong Zhang Wenwen Liu Boyan Gao Liangli (Lucy) Yu
author_sort	Jiaping Liu
title	A Novel Zein-Based Composite Nanoparticles for Improving Bioaccessibility and Anti-Inflammatory Activity of Resveratrol
title_short	A Novel Zein-Based Composite Nanoparticles for Improving Bioaccessibility and Anti-Inflammatory Activity of Resveratrol
title_full	A Novel Zein-Based Composite Nanoparticles for Improving Bioaccessibility and Anti-Inflammatory Activity of Resveratrol
title_fullStr	A Novel Zein-Based Composite Nanoparticles for Improving Bioaccessibility and Anti-Inflammatory Activity of Resveratrol
title_full_unstemmed	A Novel Zein-Based Composite Nanoparticles for Improving Bioaccessibility and Anti-Inflammatory Activity of Resveratrol
title_sort	novel zein-based composite nanoparticles for improving bioaccessibility and anti-inflammatory activity of resveratrol
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0a5b0a3c84fa4fd9ac27eeb54b37465b
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A Novel Zein-Based Composite Nanoparticles for Improving Bioaccessibility and Anti-Inflammatory Activity of Resveratrol

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