Defining a critical period for inhibitory circuits within the somatosensory cortex

Abstract Although experience-dependent changes in brain inhibitory circuits are thought to play a key role during the “critical period” of brain development, the nature and timing of these changes are poorly understood. We examined the role of sensory experience in sculpting an inhibitory circuit in...

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Autores principales:	Shun Qiang Lo, Judy C. G. Sng, George J. Augustine
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0a5b49947f6a4f428de2b616d67dc172
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spelling	oai:doaj.org-article:0a5b49947f6a4f428de2b616d67dc1722021-12-02T16:06:48ZDefining a critical period for inhibitory circuits within the somatosensory cortex10.1038/s41598-017-07400-82045-2322https://doaj.org/article/0a5b49947f6a4f428de2b616d67dc1722017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07400-8https://doaj.org/toc/2045-2322Abstract Although experience-dependent changes in brain inhibitory circuits are thought to play a key role during the “critical period” of brain development, the nature and timing of these changes are poorly understood. We examined the role of sensory experience in sculpting an inhibitory circuit in the primary somatosensory cortex (S1) of mice by using optogenetics to map the connections between parvalbumin (PV) expressing interneurons and layer 2/3 pyramidal cells. Unilateral whisker deprivation decreased the strength and spatial range of inhibitory input provided to pyramidal neurons by PV interneurons in layers 2/3, 4 and 5. By varying the time when sensory input was removed, we determined that the critical period closes around postnatal day 14. This yields the first precise time course of critical period plasticity for an inhibitory circuit.Shun Qiang LoJudy C. G. SngGeorge J. AugustineNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shun Qiang Lo Judy C. G. Sng George J. Augustine Defining a critical period for inhibitory circuits within the somatosensory cortex
description	Abstract Although experience-dependent changes in brain inhibitory circuits are thought to play a key role during the “critical period” of brain development, the nature and timing of these changes are poorly understood. We examined the role of sensory experience in sculpting an inhibitory circuit in the primary somatosensory cortex (S1) of mice by using optogenetics to map the connections between parvalbumin (PV) expressing interneurons and layer 2/3 pyramidal cells. Unilateral whisker deprivation decreased the strength and spatial range of inhibitory input provided to pyramidal neurons by PV interneurons in layers 2/3, 4 and 5. By varying the time when sensory input was removed, we determined that the critical period closes around postnatal day 14. This yields the first precise time course of critical period plasticity for an inhibitory circuit.
format	article
author	Shun Qiang Lo Judy C. G. Sng George J. Augustine
author_facet	Shun Qiang Lo Judy C. G. Sng George J. Augustine
author_sort	Shun Qiang Lo
title	Defining a critical period for inhibitory circuits within the somatosensory cortex
title_short	Defining a critical period for inhibitory circuits within the somatosensory cortex
title_full	Defining a critical period for inhibitory circuits within the somatosensory cortex
title_fullStr	Defining a critical period for inhibitory circuits within the somatosensory cortex
title_full_unstemmed	Defining a critical period for inhibitory circuits within the somatosensory cortex
title_sort	defining a critical period for inhibitory circuits within the somatosensory cortex
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0a5b49947f6a4f428de2b616d67dc172
work_keys_str_mv	AT shunqianglo definingacriticalperiodforinhibitorycircuitswithinthesomatosensorycortex AT judycgsng definingacriticalperiodforinhibitorycircuitswithinthesomatosensorycortex AT georgejaugustine definingacriticalperiodforinhibitorycircuitswithinthesomatosensorycortex
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Defining a critical period for inhibitory circuits within the somatosensory cortex

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