Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

Ibrahim M Abdulbaqi, Yusrida Darwis, Nurzalina Abdul Karim Khan, Reem Abou Assi, Arshad A Khan School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia Abstract: Ethosomal systems are novel lipid vesicular carriers containing a relatively high percentage of ethanol. These nan...

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Autores principales:	Abdulbaqi IM, Darwis Y, Khan NAK, Assi RA, Khan AA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Ethosomes Transdermal Lipid-based vesicles Delivery systems. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0a5f771da6fc4874ab5584dd8f19c10b
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spelling	oai:doaj.org-article:0a5f771da6fc4874ab5584dd8f19c10b2021-12-02T00:43:06ZEthosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials1178-2013https://doaj.org/article/0a5f771da6fc4874ab5584dd8f19c10b2016-05-01T00:00:00Zhttps://www.dovepress.com/ethosomal-nanocarriers-the-impact-of-constituents-and-formulation-tech-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ibrahim M Abdulbaqi, Yusrida Darwis, Nurzalina Abdul Karim Khan, Reem Abou Assi, Arshad A Khan School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia Abstract: Ethosomal systems are novel lipid vesicular carriers containing a relatively high percentage of ethanol. These nanocarriers are especially designed for the efficient delivery of therapeutic agents with different physicochemical properties into deep skin layers and across the skin. Ethosomes have undergone extensive research since they were invented in 1996; new compounds were added to their initial formula, which led to the production of new types of ethosomal systems. Different preparation techniques are used in the preparation of these novel carriers. For ease of application and stability, ethosomal dispersions are incorporated into gels, patches, and creams. Highly diverse in vivo models are used to evaluate their efficacy in dermal/ transdermal delivery, in addition to clinical trials. This article provides a detailed review of the ethosomal systems and categorizes them on the basis of their constituents to classical ethosomes, binary ethosomes, and transethosomes. The differences among these systems are discussed from several perspectives, including the formulation, size, ζ-potential (zeta potential), entrapment efficiency, skin-permeation properties, and stability. This paper gives a detailed review on the effects of ethosomal system constituents, preparation methods, and their significant roles in determining the final properties of these nanocarriers. Furthermore, the novel pharmaceutical dosage forms of ethosomal gels, patches, and creams are highlighted. The article also provides detailed information regarding the in vivo studies and clinical trials conducted for the evaluation of these vesicular systems. Keywords: ethosomes, transdermal, lipid-based vesicles, delivery systemsAbdulbaqi IMDarwis YKhan NAKAssi RAKhan AADove Medical PressarticleEthosomesTransdermalLipid-based vesiclesDelivery systems.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 2279-2304 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ethosomes Transdermal Lipid-based vesicles Delivery systems. Medicine (General) R5-920
spellingShingle	Ethosomes Transdermal Lipid-based vesicles Delivery systems. Medicine (General) R5-920 Abdulbaqi IM Darwis Y Khan NAK Assi RA Khan AA Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials
description	Ibrahim M Abdulbaqi, Yusrida Darwis, Nurzalina Abdul Karim Khan, Reem Abou Assi, Arshad A Khan School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia Abstract: Ethosomal systems are novel lipid vesicular carriers containing a relatively high percentage of ethanol. These nanocarriers are especially designed for the efficient delivery of therapeutic agents with different physicochemical properties into deep skin layers and across the skin. Ethosomes have undergone extensive research since they were invented in 1996; new compounds were added to their initial formula, which led to the production of new types of ethosomal systems. Different preparation techniques are used in the preparation of these novel carriers. For ease of application and stability, ethosomal dispersions are incorporated into gels, patches, and creams. Highly diverse in vivo models are used to evaluate their efficacy in dermal/ transdermal delivery, in addition to clinical trials. This article provides a detailed review of the ethosomal systems and categorizes them on the basis of their constituents to classical ethosomes, binary ethosomes, and transethosomes. The differences among these systems are discussed from several perspectives, including the formulation, size, ζ-potential (zeta potential), entrapment efficiency, skin-permeation properties, and stability. This paper gives a detailed review on the effects of ethosomal system constituents, preparation methods, and their significant roles in determining the final properties of these nanocarriers. Furthermore, the novel pharmaceutical dosage forms of ethosomal gels, patches, and creams are highlighted. The article also provides detailed information regarding the in vivo studies and clinical trials conducted for the evaluation of these vesicular systems. Keywords: ethosomes, transdermal, lipid-based vesicles, delivery systems
format	article
author	Abdulbaqi IM Darwis Y Khan NAK Assi RA Khan AA
author_facet	Abdulbaqi IM Darwis Y Khan NAK Assi RA Khan AA
author_sort	Abdulbaqi IM
title	Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials
title_short	Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials
title_full	Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials
title_fullStr	Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials
title_full_unstemmed	Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials
title_sort	ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/0a5f771da6fc4874ab5584dd8f19c10b
work_keys_str_mv	AT abdulbaqiim ethosomalnanocarrierstheimpactofconstituentsandformulationtechniquesonethosomalpropertiesinvivostudiesandclinicaltrials AT darwisy ethosomalnanocarrierstheimpactofconstituentsandformulationtechniquesonethosomalpropertiesinvivostudiesandclinicaltrials AT khannak ethosomalnanocarrierstheimpactofconstituentsandformulationtechniquesonethosomalpropertiesinvivostudiesandclinicaltrials AT assira ethosomalnanocarrierstheimpactofconstituentsandformulationtechniquesonethosomalpropertiesinvivostudiesandclinicaltrials AT khanaa ethosomalnanocarrierstheimpactofconstituentsandformulationtechniquesonethosomalpropertiesinvivostudiesandclinicaltrials
_version_	1718403477017722880

Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

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