Association between assisted reproductive technology and advanced retinopathy of prematurity

RV Paul Chan1, Yoshihiro Yonekawa1, Margaux A Morrison2,3, Grace Sun1, Ryan K Wong1, Jeffrey M Perlman4, Michael F Chiang5,6, Thomas C Lee7, M Elizabeth Hartnett3, Margaret M DeAngelis2,31Department of Ophthalmology, Weill Cornell Medical College, New York; 2Ocular Molecular Genetics Institute, Mass...

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Autores principales:	RV Paul Chan, Yoshihiro Yonekawa, Margaux A Morrison, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/0a699c0fef8c4a5aa2c24f5b2ecfc161
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spelling	oai:doaj.org-article:0a699c0fef8c4a5aa2c24f5b2ecfc1612021-12-02T00:15:18ZAssociation between assisted reproductive technology and advanced retinopathy of prematurity1177-54671177-5483https://doaj.org/article/0a699c0fef8c4a5aa2c24f5b2ecfc1612010-11-01T00:00:00Zhttp://www.dovepress.com/association-between-assisted-reproductive-technology-and-advanced-reti-a5772https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483RV Paul Chan1, Yoshihiro Yonekawa1, Margaux A Morrison2,3, Grace Sun1, Ryan K Wong1, Jeffrey M Perlman4, Michael F Chiang5,6, Thomas C Lee7, M Elizabeth Hartnett3, Margaret M DeAngelis2,31Department of Ophthalmology, Weill Cornell Medical College, New York; 2Ocular Molecular Genetics Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts; 3University of Utah School of Medicine, Moran Eye Center, Salt Lake City, Utah; 4Department of Pediatrics, Weill Cornell Medical College, New York; Departments of 5Ophthalmology and 6Biomedical Informatics, Columbia University College of Physicians and Surgeons, New York; 7The Vision Center, Children&rsquo;s Hospital Los Angeles, California, USAPurpose: To investigate the associations between assisted reproductive technology (ART) and severe retinopathy of prematurity (ROP) requiring treatment. Methods: Retrospective analyses of inborn preterm infants screened for severe ROP at the Weill Cornell Medical Center Neonatal Intensive Care Unit at the New York-Presbyterian Hospital by single factor logistic regression and multifactor models.Results: Of 399 ethnically diverse infants, 253 were conceived naturally and 146 by ART. Eight (3.16%) patients conceived naturally, and 11 (7.53%) with ART required laser treatment. In multifactor analyses, significant risks for severe ROP requiring treatment included both gestational age (odds ratio [OR] 0.34; 95% confidence interval [CI] 0.23&ndash;0.52; P&lt; 0.001) and ART ([OR] 4.70; [CI], 1.52&ndash;4.57; P = 0.007).Conclusions: ART is associated with severe ROP requiring treatment in this cohort. This is the first report that demonstrates a statistically significant association between ART and severe ROP requiring treatment in infants in the US.Keywords: retinopathy of prematurity, low birth rate, blindness, assisted reproductive technology RV Paul ChanYoshihiro YonekawaMargaux A Morrisonet alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 1385-1390 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 RV Paul Chan Yoshihiro Yonekawa Margaux A Morrison et al Association between assisted reproductive technology and advanced retinopathy of prematurity
description	RV Paul Chan1, Yoshihiro Yonekawa1, Margaux A Morrison2,3, Grace Sun1, Ryan K Wong1, Jeffrey M Perlman4, Michael F Chiang5,6, Thomas C Lee7, M Elizabeth Hartnett3, Margaret M DeAngelis2,31Department of Ophthalmology, Weill Cornell Medical College, New York; 2Ocular Molecular Genetics Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts; 3University of Utah School of Medicine, Moran Eye Center, Salt Lake City, Utah; 4Department of Pediatrics, Weill Cornell Medical College, New York; Departments of 5Ophthalmology and 6Biomedical Informatics, Columbia University College of Physicians and Surgeons, New York; 7The Vision Center, Children&rsquo;s Hospital Los Angeles, California, USAPurpose: To investigate the associations between assisted reproductive technology (ART) and severe retinopathy of prematurity (ROP) requiring treatment. Methods: Retrospective analyses of inborn preterm infants screened for severe ROP at the Weill Cornell Medical Center Neonatal Intensive Care Unit at the New York-Presbyterian Hospital by single factor logistic regression and multifactor models.Results: Of 399 ethnically diverse infants, 253 were conceived naturally and 146 by ART. Eight (3.16%) patients conceived naturally, and 11 (7.53%) with ART required laser treatment. In multifactor analyses, significant risks for severe ROP requiring treatment included both gestational age (odds ratio [OR] 0.34; 95% confidence interval [CI] 0.23&ndash;0.52; P&lt; 0.001) and ART ([OR] 4.70; [CI], 1.52&ndash;4.57; P = 0.007).Conclusions: ART is associated with severe ROP requiring treatment in this cohort. This is the first report that demonstrates a statistically significant association between ART and severe ROP requiring treatment in infants in the US.Keywords: retinopathy of prematurity, low birth rate, blindness, assisted reproductive technology
format	article
author	RV Paul Chan Yoshihiro Yonekawa Margaux A Morrison et al
author_facet	RV Paul Chan Yoshihiro Yonekawa Margaux A Morrison et al
author_sort	RV Paul Chan
title	Association between assisted reproductive technology and advanced retinopathy of prematurity
title_short	Association between assisted reproductive technology and advanced retinopathy of prematurity
title_full	Association between assisted reproductive technology and advanced retinopathy of prematurity
title_fullStr	Association between assisted reproductive technology and advanced retinopathy of prematurity
title_full_unstemmed	Association between assisted reproductive technology and advanced retinopathy of prematurity
title_sort	association between assisted reproductive technology and advanced retinopathy of prematurity
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/0a699c0fef8c4a5aa2c24f5b2ecfc161
work_keys_str_mv	AT rvpaulchan associationbetweenassistedreproductivetechnologyandadvancedretinopathyofprematurity AT yoshihiroyonekawa associationbetweenassistedreproductivetechnologyandadvancedretinopathyofprematurity AT margauxamorrison associationbetweenassistedreproductivetechnologyandadvancedretinopathyofprematurity AT etal associationbetweenassistedreproductivetechnologyandadvancedretinopathyofprematurity
_version_	1718403845490475008

Association between assisted reproductive technology and advanced retinopathy of prematurity

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