Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention

RNA localization plays an important role in transcriptome regulation. The majority of TERT transcripts are detected in the nucleus and TUG1 lncRNAs in both the nucleus and cytoplasm. Here, the authors combine single-cell RNA imaging, antisense oligonucleotides and splicing analyses to show that rete...

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Autores principales:	Gabrijela Dumbović, Ulrich Braunschweig, Heera K. Langner, Michael Smallegan, Josep Biayna, Evan P. Hass, Katarzyna Jastrzebska, Benjamin Blencowe, Thomas R. Cech, Marvin H. Caruthers, John L. Rinn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0a69eec1edfb49478cd0ef2274c07334
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spelling	oai:doaj.org-article:0a69eec1edfb49478cd0ef2274c073342021-12-02T15:56:54ZNuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention10.1038/s41467-021-23221-w2041-1723https://doaj.org/article/0a69eec1edfb49478cd0ef2274c073342021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23221-whttps://doaj.org/toc/2041-1723RNA localization plays an important role in transcriptome regulation. The majority of TERT transcripts are detected in the nucleus and TUG1 lncRNAs in both the nucleus and cytoplasm. Here, the authors combine single-cell RNA imaging, antisense oligonucleotides and splicing analyses to show that retention of specific introns drives stable compartmentalization of TERT and TUG1 transcripts in the nucleus, and that splicing of TERT retained introns is mitotically regulated.Gabrijela DumbovićUlrich BraunschweigHeera K. LangnerMichael SmalleganJosep BiaynaEvan P. HassKatarzyna JastrzebskaBenjamin BlencoweThomas R. CechMarvin H. CaruthersJohn L. RinnNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gabrijela Dumbović Ulrich Braunschweig Heera K. Langner Michael Smallegan Josep Biayna Evan P. Hass Katarzyna Jastrzebska Benjamin Blencowe Thomas R. Cech Marvin H. Caruthers John L. Rinn Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention
description	RNA localization plays an important role in transcriptome regulation. The majority of TERT transcripts are detected in the nucleus and TUG1 lncRNAs in both the nucleus and cytoplasm. Here, the authors combine single-cell RNA imaging, antisense oligonucleotides and splicing analyses to show that retention of specific introns drives stable compartmentalization of TERT and TUG1 transcripts in the nucleus, and that splicing of TERT retained introns is mitotically regulated.
format	article
author	Gabrijela Dumbović Ulrich Braunschweig Heera K. Langner Michael Smallegan Josep Biayna Evan P. Hass Katarzyna Jastrzebska Benjamin Blencowe Thomas R. Cech Marvin H. Caruthers John L. Rinn
author_facet	Gabrijela Dumbović Ulrich Braunschweig Heera K. Langner Michael Smallegan Josep Biayna Evan P. Hass Katarzyna Jastrzebska Benjamin Blencowe Thomas R. Cech Marvin H. Caruthers John L. Rinn
author_sort	Gabrijela Dumbović
title	Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention
title_short	Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention
title_full	Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention
title_fullStr	Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention
title_full_unstemmed	Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention
title_sort	nuclear compartmentalization of tert mrna and tug1 lncrna is driven by intron retention
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0a69eec1edfb49478cd0ef2274c07334
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Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention

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