Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention

Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention

RNA localization plays an important role in transcriptome regulation. The majority of TERT transcripts are detected in the nucleus and TUG1 lncRNAs in both the nucleus and cytoplasm. Here, the authors combine single-cell RNA imaging, antisense oligonucleotides and splicing analyses to show that rete...

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Autores principales: Gabrijela Dumbović, Ulrich Braunschweig, Heera K. Langner, Michael Smallegan, Josep Biayna, Evan P. Hass, Katarzyna Jastrzebska, Benjamin Blencowe, Thomas R. Cech, Marvin H. Caruthers, John L. Rinn
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/0a69eec1edfb49478cd0ef2274c07334
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