Antibacterial properties and toxicity from metallic nanomaterials

Gina V Vimbela,1,* Sang M Ngo,2,* Carolyn Fraze,3 Lei Yang,4,5 David A Stout5–7 1Department of Chemical Engineering, 2Department of Electrical Engineering, California State University, Long Beach, CA, 3Brigham Young University Idaho, Rexburg, ID, USA; 4Department of Orthopaedics, Orthopae...

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Autores principales:	Vimbela GV, Ngo SM, Fraze C, Yang L, Stout DA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Antibacterial reagents nanomaterials synthesis metals nanostructure nanoscale antibiotic resistance toxicity drug delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0a6dcd2a4b654aad98b6c771d84bceec
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spelling	oai:doaj.org-article:0a6dcd2a4b654aad98b6c771d84bceec2021-12-02T00:43:07ZAntibacterial properties and toxicity from metallic nanomaterials1178-2013https://doaj.org/article/0a6dcd2a4b654aad98b6c771d84bceec2017-05-01T00:00:00Zhttps://www.dovepress.com/antibacterial-properties-and-toxicity-from-metallic-nanomaterials-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Gina V Vimbela,1,* Sang M Ngo,2,* Carolyn Fraze,3 Lei Yang,4,5 David A Stout5–7 1Department of Chemical Engineering, 2Department of Electrical Engineering, California State University, Long Beach, CA, 3Brigham Young University Idaho, Rexburg, ID, USA; 4Department of Orthopaedics, Orthopaedic Institute, The First Affiliated Hospital, 5International Research Center for Translational Orthopaedics (IRCTO), Soochow University, Suzhou, Jiangsu, People’s Republic of China; 6Department of Mechanical and Aerospace Engineering, 7Department of Biomedical Engineering, California State University, Long Beach, CA, USA *These authors contributed equally to this work Abstract: The era of antibiotic resistance is a cause of increasing concern as bacteria continue to develop adaptive countermeasures against current antibiotics at an alarming rate. In recent years, studies have reported nanoparticles as a promising alternative to antibacterial reagents because of their exhibited antibacterial activity in several biomedical applications, including drug and gene delivery, tissue engineering, and imaging. Moreover, nanomaterial research has led to reports of a possible relationship between the morphological characteristics of a nanomaterial and the magnitude of its delivered toxicity. However, conventional synthesis of nanoparticles requires harsh chemicals and costly energy consumption. Additionally, the exact relationship between toxicity and morphology of nanomaterials has not been well established. Here, we review the recent advancements in synthesis techniques for silver, gold, copper, titanium, zinc oxide, and magnesium oxide nanomaterials and composites, with a focus on the toxicity exhibited by nanomaterials of multidimensions. This article highlights the benefits of selecting each material or metal-based composite for certain applications while also addressing possible setbacks and the toxic effects of the nanomaterials on the environment. Keywords: antibacterial reagents, nanomaterials, synthesis, metals, nanostructure, nanoscale, antibiotic resistance, toxicity, drug deliveryVimbela GVNgo SMFraze CYang LStout DADove Medical PressarticleAntibacterial reagentsnanomaterialssynthesismetalsnanostructurenanoscaleantibiotic resistancetoxicitydrug deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 3941-3965 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antibacterial reagents nanomaterials synthesis metals nanostructure nanoscale antibiotic resistance toxicity drug delivery Medicine (General) R5-920
spellingShingle	Antibacterial reagents nanomaterials synthesis metals nanostructure nanoscale antibiotic resistance toxicity drug delivery Medicine (General) R5-920 Vimbela GV Ngo SM Fraze C Yang L Stout DA Antibacterial properties and toxicity from metallic nanomaterials
description	Gina V Vimbela,1,* Sang M Ngo,2,* Carolyn Fraze,3 Lei Yang,4,5 David A Stout5–7 1Department of Chemical Engineering, 2Department of Electrical Engineering, California State University, Long Beach, CA, 3Brigham Young University Idaho, Rexburg, ID, USA; 4Department of Orthopaedics, Orthopaedic Institute, The First Affiliated Hospital, 5International Research Center for Translational Orthopaedics (IRCTO), Soochow University, Suzhou, Jiangsu, People’s Republic of China; 6Department of Mechanical and Aerospace Engineering, 7Department of Biomedical Engineering, California State University, Long Beach, CA, USA *These authors contributed equally to this work Abstract: The era of antibiotic resistance is a cause of increasing concern as bacteria continue to develop adaptive countermeasures against current antibiotics at an alarming rate. In recent years, studies have reported nanoparticles as a promising alternative to antibacterial reagents because of their exhibited antibacterial activity in several biomedical applications, including drug and gene delivery, tissue engineering, and imaging. Moreover, nanomaterial research has led to reports of a possible relationship between the morphological characteristics of a nanomaterial and the magnitude of its delivered toxicity. However, conventional synthesis of nanoparticles requires harsh chemicals and costly energy consumption. Additionally, the exact relationship between toxicity and morphology of nanomaterials has not been well established. Here, we review the recent advancements in synthesis techniques for silver, gold, copper, titanium, zinc oxide, and magnesium oxide nanomaterials and composites, with a focus on the toxicity exhibited by nanomaterials of multidimensions. This article highlights the benefits of selecting each material or metal-based composite for certain applications while also addressing possible setbacks and the toxic effects of the nanomaterials on the environment. Keywords: antibacterial reagents, nanomaterials, synthesis, metals, nanostructure, nanoscale, antibiotic resistance, toxicity, drug delivery
format	article
author	Vimbela GV Ngo SM Fraze C Yang L Stout DA
author_facet	Vimbela GV Ngo SM Fraze C Yang L Stout DA
author_sort	Vimbela GV
title	Antibacterial properties and toxicity from metallic nanomaterials
title_short	Antibacterial properties and toxicity from metallic nanomaterials
title_full	Antibacterial properties and toxicity from metallic nanomaterials
title_fullStr	Antibacterial properties and toxicity from metallic nanomaterials
title_full_unstemmed	Antibacterial properties and toxicity from metallic nanomaterials
title_sort	antibacterial properties and toxicity from metallic nanomaterials
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/0a6dcd2a4b654aad98b6c771d84bceec
work_keys_str_mv	AT vimbelagv antibacterialpropertiesandtoxicityfrommetallicnanomaterials AT ngosm antibacterialpropertiesandtoxicityfrommetallicnanomaterials AT frazec antibacterialpropertiesandtoxicityfrommetallicnanomaterials AT yangl antibacterialpropertiesandtoxicityfrommetallicnanomaterials AT stoutda antibacterialpropertiesandtoxicityfrommetallicnanomaterials
_version_	1718403477229535232

Antibacterial properties and toxicity from metallic nanomaterials

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