Roles of OX40 and OX40 Ligand in Mycosis Fungoides and Sézary Syndrome

Mycosis fungoides (MF) and Sézary syndrome (SS), the most common types of cutaneous T-cell lymphoma (CTCL), are characterized by proliferation of mature CD4+ T-helper cells. Patients with advanced-stage MF and SS have poor prognosis, with 5-year survival rates of 52%. Although a variety of systemic...

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Autores principales:	Yuki Kawana, Hiraku Suga, Hiroaki Kamijo, Tomomitsu Miyagaki, Makoto Sugaya, Shinichi Sato
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mycosis fungoides Sézary syndrome cutaneous T-cell lymphoma OX40 TNF receptor superfamily Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/0a6e6cf1c3304721b2a12a91acf1db33
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spelling	oai:doaj.org-article:0a6e6cf1c3304721b2a12a91acf1db332021-11-25T17:58:06ZRoles of OX40 and OX40 Ligand in Mycosis Fungoides and Sézary Syndrome10.3390/ijms2222125761422-00671661-6596https://doaj.org/article/0a6e6cf1c3304721b2a12a91acf1db332021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12576https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Mycosis fungoides (MF) and Sézary syndrome (SS), the most common types of cutaneous T-cell lymphoma (CTCL), are characterized by proliferation of mature CD4+ T-helper cells. Patients with advanced-stage MF and SS have poor prognosis, with 5-year survival rates of 52%. Although a variety of systemic therapies are currently available, there are no curative options for such patients except for stem cell transplantation, and thus the treatment of advanced MF and SS still remains challenging. Therefore, elucidation of the pathophysiology of MF/SS and development of medical treatments are desired. In this study, we focused on a molecule called OX40. We examined OX40 and OX40L expression and function using clinical samples of MF and SS and CTCL cell lines. OX40 and OX40L were co-expressed on tumor cells of MF and SS. OX40 and OX40L expression was increased and correlated with disease severity markers in MF/SS patients. Anti-OX40 antibody and anti-OX40L antibody suppressed the proliferation of CTCL cell lines both in vitro and in vivo. These results suggest that OX40–OX40L interactions could contribute to the proliferation of MF/SS tumor cells and that the disruption of OX40–OX40L interactions could become a new therapeutic strategy for the treatment of MF/SS.Yuki KawanaHiraku SugaHiroaki KamijoTomomitsu MiyagakiMakoto SugayaShinichi SatoMDPI AGarticlemycosis fungoidesSézary syndromecutaneous T-cell lymphomaOX40TNF receptor superfamilyBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12576, p 12576 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mycosis fungoides Sézary syndrome cutaneous T-cell lymphoma OX40 TNF receptor superfamily Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	mycosis fungoides Sézary syndrome cutaneous T-cell lymphoma OX40 TNF receptor superfamily Biology (General) QH301-705.5 Chemistry QD1-999 Yuki Kawana Hiraku Suga Hiroaki Kamijo Tomomitsu Miyagaki Makoto Sugaya Shinichi Sato Roles of OX40 and OX40 Ligand in Mycosis Fungoides and Sézary Syndrome
description	Mycosis fungoides (MF) and Sézary syndrome (SS), the most common types of cutaneous T-cell lymphoma (CTCL), are characterized by proliferation of mature CD4+ T-helper cells. Patients with advanced-stage MF and SS have poor prognosis, with 5-year survival rates of 52%. Although a variety of systemic therapies are currently available, there are no curative options for such patients except for stem cell transplantation, and thus the treatment of advanced MF and SS still remains challenging. Therefore, elucidation of the pathophysiology of MF/SS and development of medical treatments are desired. In this study, we focused on a molecule called OX40. We examined OX40 and OX40L expression and function using clinical samples of MF and SS and CTCL cell lines. OX40 and OX40L were co-expressed on tumor cells of MF and SS. OX40 and OX40L expression was increased and correlated with disease severity markers in MF/SS patients. Anti-OX40 antibody and anti-OX40L antibody suppressed the proliferation of CTCL cell lines both in vitro and in vivo. These results suggest that OX40–OX40L interactions could contribute to the proliferation of MF/SS tumor cells and that the disruption of OX40–OX40L interactions could become a new therapeutic strategy for the treatment of MF/SS.
format	article
author	Yuki Kawana Hiraku Suga Hiroaki Kamijo Tomomitsu Miyagaki Makoto Sugaya Shinichi Sato
author_facet	Yuki Kawana Hiraku Suga Hiroaki Kamijo Tomomitsu Miyagaki Makoto Sugaya Shinichi Sato
author_sort	Yuki Kawana
title	Roles of OX40 and OX40 Ligand in Mycosis Fungoides and Sézary Syndrome
title_short	Roles of OX40 and OX40 Ligand in Mycosis Fungoides and Sézary Syndrome
title_full	Roles of OX40 and OX40 Ligand in Mycosis Fungoides and Sézary Syndrome
title_fullStr	Roles of OX40 and OX40 Ligand in Mycosis Fungoides and Sézary Syndrome
title_full_unstemmed	Roles of OX40 and OX40 Ligand in Mycosis Fungoides and Sézary Syndrome
title_sort	roles of ox40 and ox40 ligand in mycosis fungoides and sézary syndrome
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0a6e6cf1c3304721b2a12a91acf1db33
work_keys_str_mv	AT yukikawana rolesofox40andox40ligandinmycosisfungoidesandsezarysyndrome AT hirakusuga rolesofox40andox40ligandinmycosisfungoidesandsezarysyndrome AT hiroakikamijo rolesofox40andox40ligandinmycosisfungoidesandsezarysyndrome AT tomomitsumiyagaki rolesofox40andox40ligandinmycosisfungoidesandsezarysyndrome AT makotosugaya rolesofox40andox40ligandinmycosisfungoidesandsezarysyndrome AT shinichisato rolesofox40andox40ligandinmycosisfungoidesandsezarysyndrome
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Roles of OX40 and OX40 Ligand in Mycosis Fungoides and Sézary Syndrome

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