Identification and characterization of a broadly cross-reactive HIV-1 human monoclonal antibody that binds to both gp120 and gp41.

Identification of broadly cross-reactive HIV-1-neutralizing antibodies (bnAbs) may assist vaccine immunogen design. Here we report a novel human monoclonal antibody (mAb), designated m43, which co-targets the gp120 and gp41 subunits of the HIV-1 envelope glycoprotein (Env). M43 bound to recombinant...

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Autores principales:	Mei-Yun Zhang, Tingting Yuan, Jingjing Li, Andrew Rosa Borges, Jennifer D Watkins, Javier Guenaga, Zheng Yang, Yanping Wang, Richard Wilson, Yuxing Li, Victoria R Polonis, Seth H Pincus, Ruth M Ruprecht, Dimiter S Dimitrov
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0a713389e84f46b3a4b358d4a37ce068
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Identification and characterization of a broadly cross-reactive HIV-1 human monoclonal antibody that binds to both gp120 and gp41.

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