Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis.

<h4>Background</h4>So far, many studies have investigated the distribution of CCR5 genotype between HIV-1 infected patients and uninfected people. However, no definite results have been put forward about whether heterozygosity for a 32-basepair deletion in CCR5 gene (CCR5-Δ32) can affect...

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Autores principales:	Sijie Liu, Chuijin Kong, Jie Wu, Hao Ying, Huanzhang Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0a71d0c095e44214ad5eb93ba023f5be
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spelling	oai:doaj.org-article:0a71d0c095e44214ad5eb93ba023f5be2021-11-18T07:23:10ZEffect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis.1932-620310.1371/journal.pone.0035020https://doaj.org/article/0a71d0c095e44214ad5eb93ba023f5be2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22496885/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>So far, many studies have investigated the distribution of CCR5 genotype between HIV-1 infected patients and uninfected people. However, no definite results have been put forward about whether heterozygosity for a 32-basepair deletion in CCR5 gene (CCR5-Δ32) can affect HIV-1 susceptibility.<h4>Methods</h4>We performed a meta-analysis of 18 studies including more than 12000 subjects for whom the CCR5-Δ32 polymorphism was genotyped. Odds ratio (OR) with 95% confidence interval (CI) were employed to assess the association of CCR5-Δ32 polymorphism with HIV-1 susceptibility.<h4>Results</h4>Compared with the wild-type CCR5 homozygotes, the pooled OR for CCR5-Δ32 heterozygotes was 1.02 (95%CI, 0.88-1.19) for healthy controls (HC) and 0.95 (95%CI, 0.71-1.26) for exposed uninfected (EU) controls. Similar results were found in stratified analysis by ethnicity, sample size and method of CCR5-Δ32 genotyping.<h4>Conclusions</h4>The meta-analysis indicated that HIV-1 susceptibility is not significantly affected by heterozygosity for CCR5-Δ32.Sijie LiuChuijin KongJie WuHao YingHuanzhang ZhuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e35020 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sijie Liu Chuijin Kong Jie Wu Hao Ying Huanzhang Zhu Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis.
description	<h4>Background</h4>So far, many studies have investigated the distribution of CCR5 genotype between HIV-1 infected patients and uninfected people. However, no definite results have been put forward about whether heterozygosity for a 32-basepair deletion in CCR5 gene (CCR5-Δ32) can affect HIV-1 susceptibility.<h4>Methods</h4>We performed a meta-analysis of 18 studies including more than 12000 subjects for whom the CCR5-Δ32 polymorphism was genotyped. Odds ratio (OR) with 95% confidence interval (CI) were employed to assess the association of CCR5-Δ32 polymorphism with HIV-1 susceptibility.<h4>Results</h4>Compared with the wild-type CCR5 homozygotes, the pooled OR for CCR5-Δ32 heterozygotes was 1.02 (95%CI, 0.88-1.19) for healthy controls (HC) and 0.95 (95%CI, 0.71-1.26) for exposed uninfected (EU) controls. Similar results were found in stratified analysis by ethnicity, sample size and method of CCR5-Δ32 genotyping.<h4>Conclusions</h4>The meta-analysis indicated that HIV-1 susceptibility is not significantly affected by heterozygosity for CCR5-Δ32.
format	article
author	Sijie Liu Chuijin Kong Jie Wu Hao Ying Huanzhang Zhu
author_facet	Sijie Liu Chuijin Kong Jie Wu Hao Ying Huanzhang Zhu
author_sort	Sijie Liu
title	Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis.
title_short	Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis.
title_full	Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis.
title_fullStr	Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis.
title_full_unstemmed	Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis.
title_sort	effect of ccr5-δ32 heterozygosity on hiv-1 susceptibility: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/0a71d0c095e44214ad5eb93ba023f5be
work_keys_str_mv	AT sijieliu effectofccr5d32heterozygosityonhiv1susceptibilityametaanalysis AT chuijinkong effectofccr5d32heterozygosityonhiv1susceptibilityametaanalysis AT jiewu effectofccr5d32heterozygosityonhiv1susceptibilityametaanalysis AT haoying effectofccr5d32heterozygosityonhiv1susceptibilityametaanalysis AT huanzhangzhu effectofccr5d32heterozygosityonhiv1susceptibilityametaanalysis
_version_	1718423515754921984

Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis.

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