Using 4DCBCT simulation and guidance to evaluate inter-fractional tumor variance during SABR for lung tumor within the lower lobe

Using 4DCBCT simulation and guidance to evaluate inter-fractional tumor variance during SABR for lung tumor within the lower lobe

Abstract Inter-fractional tumor variance would lead to insufficient dosage or overdose in tumor region during lung cancer radiotherapy. However, previous works have not considered influence of inter-fractional tumor amplitude variance at treatment position due to lack of effective evaluation method...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Yi Li, Wenjing Wu, Ruixin He, Yongkai Lu, Yuemei Zhang, Long Wang, Xiaozhi Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/0a74e161fa854e7cacddea37a0e64f73
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:0a74e161fa854e7cacddea37a0e64f73
record_format dspace
spelling oai:doaj.org-article:0a74e161fa854e7cacddea37a0e64f732021-12-02T19:16:15ZUsing 4DCBCT simulation and guidance to evaluate inter-fractional tumor variance during SABR for lung tumor within the lower lobe10.1038/s41598-021-99489-12045-2322https://doaj.org/article/0a74e161fa854e7cacddea37a0e64f732021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99489-1https://doaj.org/toc/2045-2322Abstract Inter-fractional tumor variance would lead to insufficient dosage or overdose in tumor region during lung cancer radiotherapy. However, previous works have not considered influence of inter-fractional tumor amplitude variance at treatment position due to lack of effective evaluation method during radiotherapy, especially for lung tumor within the lower lobe. Our objective was to investigate inter-fractional tumor baseline shift and amplitude variance due to respiratory motion with 4DCBCT simulation and guidance during stereotactic ablative body radiotherapy (SABR) for lung tumor. Subject included 19 patients with lung tumor within the lower lobe. 4DCBCT-simulated images at treatment position were acquired sequentially to determine internal tumor volume (ITV) and reference tumor motion at simulation process. Compared with reference tumor motion, 95 4DCBCT-guided images were acquired during each treatment to evaluate inter-fractional tumor baseline shift and amplitude variance, which were − 0.0 ± 1.3 mm and − 0.2 ± 1.4 mm in left–right(LR) direction, 0.9 ± 2.3 mm and 0.4 ± 2.9 mm in superior-inferior (SI) direction, 0.1 ± 1.5 mm and − 0.4 ± 2.0 mm in anterior–posterior (AP) direction. ITV margin were 3.5 mm, 7.5 mm and 5.3 mm in LR, SI and AP directions with van Herk’s (Int J Radiat Oncol Biol Phys 52(5):1407–1422, 2002) formula. 4DCBCT simulation and guidance is a reliable method to evaluate inter-fractional tumor variance during SABR for lung tumor within the lower lobe. ITV margin of 3.5 mm, 7.5 mm and 5.3 mm in LR, SI and AP directions would ensure greater tumor coverage during SABR for lung tumor within the lower lobe.Yi LiWenjing WuRuixin HeYongkai LuYuemei ZhangLong WangXiaozhi ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Yi Li
Wenjing Wu
Ruixin He
Yongkai Lu
Yuemei Zhang
Long Wang
Xiaozhi Zhang
Using 4DCBCT simulation and guidance to evaluate inter-fractional tumor variance during SABR for lung tumor within the lower lobe
description Abstract Inter-fractional tumor variance would lead to insufficient dosage or overdose in tumor region during lung cancer radiotherapy. However, previous works have not considered influence of inter-fractional tumor amplitude variance at treatment position due to lack of effective evaluation method during radiotherapy, especially for lung tumor within the lower lobe. Our objective was to investigate inter-fractional tumor baseline shift and amplitude variance due to respiratory motion with 4DCBCT simulation and guidance during stereotactic ablative body radiotherapy (SABR) for lung tumor. Subject included 19 patients with lung tumor within the lower lobe. 4DCBCT-simulated images at treatment position were acquired sequentially to determine internal tumor volume (ITV) and reference tumor motion at simulation process. Compared with reference tumor motion, 95 4DCBCT-guided images were acquired during each treatment to evaluate inter-fractional tumor baseline shift and amplitude variance, which were − 0.0 ± 1.3 mm and − 0.2 ± 1.4 mm in left–right(LR) direction, 0.9 ± 2.3 mm and 0.4 ± 2.9 mm in superior-inferior (SI) direction, 0.1 ± 1.5 mm and − 0.4 ± 2.0 mm in anterior–posterior (AP) direction. ITV margin were 3.5 mm, 7.5 mm and 5.3 mm in LR, SI and AP directions with van Herk’s (Int J Radiat Oncol Biol Phys 52(5):1407–1422, 2002) formula. 4DCBCT simulation and guidance is a reliable method to evaluate inter-fractional tumor variance during SABR for lung tumor within the lower lobe. ITV margin of 3.5 mm, 7.5 mm and 5.3 mm in LR, SI and AP directions would ensure greater tumor coverage during SABR for lung tumor within the lower lobe.
format article
author Yi Li
Wenjing Wu
Ruixin He
Yongkai Lu
Yuemei Zhang
Long Wang
Xiaozhi Zhang
author_facet Yi Li
Wenjing Wu
Ruixin He
Yongkai Lu
Yuemei Zhang
Long Wang
Xiaozhi Zhang
author_sort Yi Li
title Using 4DCBCT simulation and guidance to evaluate inter-fractional tumor variance during SABR for lung tumor within the lower lobe
title_short Using 4DCBCT simulation and guidance to evaluate inter-fractional tumor variance during SABR for lung tumor within the lower lobe
title_full Using 4DCBCT simulation and guidance to evaluate inter-fractional tumor variance during SABR for lung tumor within the lower lobe
title_fullStr Using 4DCBCT simulation and guidance to evaluate inter-fractional tumor variance during SABR for lung tumor within the lower lobe
title_full_unstemmed Using 4DCBCT simulation and guidance to evaluate inter-fractional tumor variance during SABR for lung tumor within the lower lobe
title_sort using 4dcbct simulation and guidance to evaluate inter-fractional tumor variance during sabr for lung tumor within the lower lobe
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/0a74e161fa854e7cacddea37a0e64f73
work_keys_str_mv AT yili using4dcbctsimulationandguidancetoevaluateinterfractionaltumorvarianceduringsabrforlungtumorwithinthelowerlobe
AT wenjingwu using4dcbctsimulationandguidancetoevaluateinterfractionaltumorvarianceduringsabrforlungtumorwithinthelowerlobe
AT ruixinhe using4dcbctsimulationandguidancetoevaluateinterfractionaltumorvarianceduringsabrforlungtumorwithinthelowerlobe
AT yongkailu using4dcbctsimulationandguidancetoevaluateinterfractionaltumorvarianceduringsabrforlungtumorwithinthelowerlobe
AT yuemeizhang using4dcbctsimulationandguidancetoevaluateinterfractionaltumorvarianceduringsabrforlungtumorwithinthelowerlobe
AT longwang using4dcbctsimulationandguidancetoevaluateinterfractionaltumorvarianceduringsabrforlungtumorwithinthelowerlobe
AT xiaozhizhang using4dcbctsimulationandguidancetoevaluateinterfractionaltumorvarianceduringsabrforlungtumorwithinthelowerlobe
_version_ 1718376954333233152

Ejemplares similares