High HIV-1 diversity in immigrants resident in Italy (2008–2017)

Abstract The proportion of new diagnoses of HIV infection in immigrants residing in Italy raised from 11% in 1992 to 29.7% in 2018. To investigate the HIV clades circulating in this community a retrospective study was performed in 557 HIV-infected immigrants living in 12 Italian cities. Immigrants o...

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Autores principales:	Maria Teresa Maggiorella, Nunzia Sanarico, Gaetano Brindicci, Laura Monno, Carmen Rita Santoro, Nicola Coppola, Nunzia Cuomo, Annalisa Azzurri, Francesco Cesario, Filippo Luciani, Issa El-Hamad, Gabriella D’Ettorre, Ombretta Turriziani, Laura Mazzuti, Alessandra Poggi, Francesca Vichi, Elisa Mariabelli, Lorenzo Surace, Giuseppina Berardelli, Orietta Picconi, Alessandra Cenci, Leonardo Sernicola, Claudia Rovetto, Domenico Fulgenzi, Roberto Belli, Emanuela Salvi, Patrizia Di Zeo, Alessandra Borsetti, Barbara Ridolfi, Ruggero Losappio, Fabio Zoboli, Ivan Schietroma, Eleonora Cella, Silvia Angeletti, Massimo Ciccozzi, Stefania D’Amato, Barbara Ensoli, Stefano Buttò, the Italian Network for HIV Characterization
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0a7696423e184fde8c09b6a9b400842f
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spelling	oai:doaj.org-article:0a7696423e184fde8c09b6a9b400842f2021-12-02T14:28:21ZHigh HIV-1 diversity in immigrants resident in Italy (2008–2017)10.1038/s41598-020-59084-22045-2322https://doaj.org/article/0a7696423e184fde8c09b6a9b400842f2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-59084-2https://doaj.org/toc/2045-2322Abstract The proportion of new diagnoses of HIV infection in immigrants residing in Italy raised from 11% in 1992 to 29.7% in 2018. To investigate the HIV clades circulating in this community a retrospective study was performed in 557 HIV-infected immigrants living in 12 Italian cities. Immigrants originated from East-Europe and Central-Asia (11.7%), North Africa and Middle East (7.3%), South and South-East Asia (7.2%), Latin America and the Caribbean (14.4%), and sub-Saharan Africa (59.4%). More than 87% of immigrants were on antiretroviral therapy (ART), although 26.6% of them were viremic. A 22.0% of immigrants had hepatitis (HBV and/or HCV) and/or tuberculosis. HIV phylogenetic analysis on sequences from 192 immigrants showed the presence of clades B (23.4%), G (16.1%), C (10.4%), A1 (9.4%), F1 (5.2%), D (1.6%) and Circulating Recombinant Forms (CRFs) (33.9%). CRF02_AG represented 72.3% of the total CRFs. Clusters between immigrants and Italian natives were also present. Drug resistance mutations to NRTI, NNRTI, and PI drug classes occurred in 29.1% of ART-treated and in 12.9% of ART-naïve individuals. These data highlight the need for tailored public health interventions in immigrants to avoid spreading in Italy of HIV genetic forms and ART-resistant variants, as well as HIV co-morbidities.Maria Teresa MaggiorellaNunzia SanaricoGaetano BrindicciLaura MonnoCarmen Rita SantoroNicola CoppolaNunzia CuomoAnnalisa AzzurriFrancesco CesarioFilippo LucianiIssa El-HamadGabriella D’EttorreOmbretta TurrizianiLaura MazzutiAlessandra PoggiFrancesca VichiElisa MariabelliLorenzo SuraceGiuseppina BerardelliOrietta PicconiAlessandra CenciLeonardo SernicolaClaudia RovettoDomenico FulgenziRoberto BelliEmanuela SalviPatrizia Di ZeoAlessandra BorsettiBarbara RidolfiRuggero LosappioFabio ZoboliIvan SchietromaEleonora CellaSilvia AngelettiMassimo CiccozziStefania D’AmatoBarbara EnsoliStefano Buttòthe Italian Network for HIV CharacterizationNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Teresa Maggiorella Nunzia Sanarico Gaetano Brindicci Laura Monno Carmen Rita Santoro Nicola Coppola Nunzia Cuomo Annalisa Azzurri Francesco Cesario Filippo Luciani Issa El-Hamad Gabriella D’Ettorre Ombretta Turriziani Laura Mazzuti Alessandra Poggi Francesca Vichi Elisa Mariabelli Lorenzo Surace Giuseppina Berardelli Orietta Picconi Alessandra Cenci Leonardo Sernicola Claudia Rovetto Domenico Fulgenzi Roberto Belli Emanuela Salvi Patrizia Di Zeo Alessandra Borsetti Barbara Ridolfi Ruggero Losappio Fabio Zoboli Ivan Schietroma Eleonora Cella Silvia Angeletti Massimo Ciccozzi Stefania D’Amato Barbara Ensoli Stefano Buttò the Italian Network for HIV Characterization High HIV-1 diversity in immigrants resident in Italy (2008–2017)
description	Abstract The proportion of new diagnoses of HIV infection in immigrants residing in Italy raised from 11% in 1992 to 29.7% in 2018. To investigate the HIV clades circulating in this community a retrospective study was performed in 557 HIV-infected immigrants living in 12 Italian cities. Immigrants originated from East-Europe and Central-Asia (11.7%), North Africa and Middle East (7.3%), South and South-East Asia (7.2%), Latin America and the Caribbean (14.4%), and sub-Saharan Africa (59.4%). More than 87% of immigrants were on antiretroviral therapy (ART), although 26.6% of them were viremic. A 22.0% of immigrants had hepatitis (HBV and/or HCV) and/or tuberculosis. HIV phylogenetic analysis on sequences from 192 immigrants showed the presence of clades B (23.4%), G (16.1%), C (10.4%), A1 (9.4%), F1 (5.2%), D (1.6%) and Circulating Recombinant Forms (CRFs) (33.9%). CRF02_AG represented 72.3% of the total CRFs. Clusters between immigrants and Italian natives were also present. Drug resistance mutations to NRTI, NNRTI, and PI drug classes occurred in 29.1% of ART-treated and in 12.9% of ART-naïve individuals. These data highlight the need for tailored public health interventions in immigrants to avoid spreading in Italy of HIV genetic forms and ART-resistant variants, as well as HIV co-morbidities.
format	article
author	Maria Teresa Maggiorella Nunzia Sanarico Gaetano Brindicci Laura Monno Carmen Rita Santoro Nicola Coppola Nunzia Cuomo Annalisa Azzurri Francesco Cesario Filippo Luciani Issa El-Hamad Gabriella D’Ettorre Ombretta Turriziani Laura Mazzuti Alessandra Poggi Francesca Vichi Elisa Mariabelli Lorenzo Surace Giuseppina Berardelli Orietta Picconi Alessandra Cenci Leonardo Sernicola Claudia Rovetto Domenico Fulgenzi Roberto Belli Emanuela Salvi Patrizia Di Zeo Alessandra Borsetti Barbara Ridolfi Ruggero Losappio Fabio Zoboli Ivan Schietroma Eleonora Cella Silvia Angeletti Massimo Ciccozzi Stefania D’Amato Barbara Ensoli Stefano Buttò the Italian Network for HIV Characterization
author_facet	Maria Teresa Maggiorella Nunzia Sanarico Gaetano Brindicci Laura Monno Carmen Rita Santoro Nicola Coppola Nunzia Cuomo Annalisa Azzurri Francesco Cesario Filippo Luciani Issa El-Hamad Gabriella D’Ettorre Ombretta Turriziani Laura Mazzuti Alessandra Poggi Francesca Vichi Elisa Mariabelli Lorenzo Surace Giuseppina Berardelli Orietta Picconi Alessandra Cenci Leonardo Sernicola Claudia Rovetto Domenico Fulgenzi Roberto Belli Emanuela Salvi Patrizia Di Zeo Alessandra Borsetti Barbara Ridolfi Ruggero Losappio Fabio Zoboli Ivan Schietroma Eleonora Cella Silvia Angeletti Massimo Ciccozzi Stefania D’Amato Barbara Ensoli Stefano Buttò the Italian Network for HIV Characterization
author_sort	Maria Teresa Maggiorella
title	High HIV-1 diversity in immigrants resident in Italy (2008–2017)
title_short	High HIV-1 diversity in immigrants resident in Italy (2008–2017)
title_full	High HIV-1 diversity in immigrants resident in Italy (2008–2017)
title_fullStr	High HIV-1 diversity in immigrants resident in Italy (2008–2017)
title_full_unstemmed	High HIV-1 diversity in immigrants resident in Italy (2008–2017)
title_sort	high hiv-1 diversity in immigrants resident in italy (2008–2017)
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0a7696423e184fde8c09b6a9b400842f
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High HIV-1 diversity in immigrants resident in Italy (2008–2017)

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