Autoregulation of yeast ribosomal proteins discovered by efficient search for feedback regulation

Here, the authors screen for feedback regulation of ribosomal proteins by overexpressing a non- regulatable version of a gene and observing its effects on the expression of the GFP-fused version. They find that 30% show at least a 3-fold reduction in expression and two genes show a 10-fold reduction...

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Autores principales:	Basab Roy, David Granas, Fredrick Bragg, Jonathan A. Y. Cher, Michael A. White, Gary D. Stormo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0a77fcbad36d43d1b21bdd3be24384d7
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spelling	oai:doaj.org-article:0a77fcbad36d43d1b21bdd3be24384d72021-12-02T11:43:43ZAutoregulation of yeast ribosomal proteins discovered by efficient search for feedback regulation10.1038/s42003-020-01494-z2399-3642https://doaj.org/article/0a77fcbad36d43d1b21bdd3be24384d72020-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01494-zhttps://doaj.org/toc/2399-3642Here, the authors screen for feedback regulation of ribosomal proteins by overexpressing a non- regulatable version of a gene and observing its effects on the expression of the GFP-fused version. They find that 30% show at least a 3-fold reduction in expression and two genes show a 10-fold reduction with the regulatory site being in the 5’ untranslated region of the gene.Basab RoyDavid GranasFredrick BraggJonathan A. Y. CherMichael A. WhiteGary D. StormoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Basab Roy David Granas Fredrick Bragg Jonathan A. Y. Cher Michael A. White Gary D. Stormo Autoregulation of yeast ribosomal proteins discovered by efficient search for feedback regulation
description	Here, the authors screen for feedback regulation of ribosomal proteins by overexpressing a non- regulatable version of a gene and observing its effects on the expression of the GFP-fused version. They find that 30% show at least a 3-fold reduction in expression and two genes show a 10-fold reduction with the regulatory site being in the 5’ untranslated region of the gene.
format	article
author	Basab Roy David Granas Fredrick Bragg Jonathan A. Y. Cher Michael A. White Gary D. Stormo
author_facet	Basab Roy David Granas Fredrick Bragg Jonathan A. Y. Cher Michael A. White Gary D. Stormo
author_sort	Basab Roy
title	Autoregulation of yeast ribosomal proteins discovered by efficient search for feedback regulation
title_short	Autoregulation of yeast ribosomal proteins discovered by efficient search for feedback regulation
title_full	Autoregulation of yeast ribosomal proteins discovered by efficient search for feedback regulation
title_fullStr	Autoregulation of yeast ribosomal proteins discovered by efficient search for feedback regulation
title_full_unstemmed	Autoregulation of yeast ribosomal proteins discovered by efficient search for feedback regulation
title_sort	autoregulation of yeast ribosomal proteins discovered by efficient search for feedback regulation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0a77fcbad36d43d1b21bdd3be24384d7
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Autoregulation of yeast ribosomal proteins discovered by efficient search for feedback regulation

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