Structural insights into the π-π-π stacking mechanism and DNA-binding activity of the YEATS domain

Structural insights into the π-π-π stacking mechanism and DNA-binding activity of the YEATS domain

YEATS domains are histone acylation readers that recognize crotonyllysine and acetyllysine. Here the authors provide structural insights into how YEATS domains recognize acetyllysines and further show that the human AF9 YEATS domain also binds DNA.

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Detalles Bibliográficos
Autores principales: Brianna J. Klein, Kendra R. Vann, Forest H. Andrews, Wesley W. Wang, Jibo Zhang, Yi Zhang, Anastasia A. Beloglazkina, Wenyi Mi, Yuanyuan Li, Haitao Li, Xiaobing Shi, Andrei G. Kutateladze, Brian D. Strahl, Wenshe R. Liu, Tatiana G. Kutateladze
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/0a782d5b6bf841aea5a1f2ccefd9b04c
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Descripción
Sumario:YEATS domains are histone acylation readers that recognize crotonyllysine and acetyllysine. Here the authors provide structural insights into how YEATS domains recognize acetyllysines and further show that the human AF9 YEATS domain also binds DNA.

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