Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines

Hepatocytes grown in a dish are immature and do not metabolize compounds as a real liver would. Here, the authors supply stem cell-derived hepatocytes with amino acids at a higher concentration than nutritionally necessary, changing the metabolism of these cells, making them more mature and useful f...

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Autores principales:	Ruben Boon, Manoj Kumar, Tine Tricot, Ilaria Elia, Laura Ordovas, Frank Jacobs, Jennifer One, Jonathan De Smedt, Guy Eelen, Matthew Bird, Philip Roelandt, Ginevra Doglioni, Kim Vriens, Matteo Rossi, Marta Aguirre Vazquez, Thomas Vanwelden, François Chesnais, Adil El Taghdouini, Mustapha Najimi, Etienne Sokal, David Cassiman, Jan Snoeys, Mario Monshouwer, Wei-Shou Hu, Christian Lange, Peter Carmeliet, Sarah-Maria Fendt, Catherine M. Verfaillie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0a789642bd074590a245141b427513bf
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spelling	oai:doaj.org-article:0a789642bd074590a245141b427513bf2021-12-02T17:32:14ZAmino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines10.1038/s41467-020-15058-62041-1723https://doaj.org/article/0a789642bd074590a245141b427513bf2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15058-6https://doaj.org/toc/2041-1723Hepatocytes grown in a dish are immature and do not metabolize compounds as a real liver would. Here, the authors supply stem cell-derived hepatocytes with amino acids at a higher concentration than nutritionally necessary, changing the metabolism of these cells, making them more mature and useful for drug screening and toxicity studies.Ruben BoonManoj KumarTine TricotIlaria EliaLaura OrdovasFrank JacobsJennifer OneJonathan De SmedtGuy EelenMatthew BirdPhilip RoelandtGinevra DoglioniKim VriensMatteo RossiMarta Aguirre VazquezThomas VanweldenFrançois ChesnaisAdil El TaghdouiniMustapha NajimiEtienne SokalDavid CassimanJan SnoeysMario MonshouwerWei-Shou HuChristian LangePeter CarmelietSarah-Maria FendtCatherine M. VerfaillieNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ruben Boon Manoj Kumar Tine Tricot Ilaria Elia Laura Ordovas Frank Jacobs Jennifer One Jonathan De Smedt Guy Eelen Matthew Bird Philip Roelandt Ginevra Doglioni Kim Vriens Matteo Rossi Marta Aguirre Vazquez Thomas Vanwelden François Chesnais Adil El Taghdouini Mustapha Najimi Etienne Sokal David Cassiman Jan Snoeys Mario Monshouwer Wei-Shou Hu Christian Lange Peter Carmeliet Sarah-Maria Fendt Catherine M. Verfaillie Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines
description	Hepatocytes grown in a dish are immature and do not metabolize compounds as a real liver would. Here, the authors supply stem cell-derived hepatocytes with amino acids at a higher concentration than nutritionally necessary, changing the metabolism of these cells, making them more mature and useful for drug screening and toxicity studies.
format	article
author	Ruben Boon Manoj Kumar Tine Tricot Ilaria Elia Laura Ordovas Frank Jacobs Jennifer One Jonathan De Smedt Guy Eelen Matthew Bird Philip Roelandt Ginevra Doglioni Kim Vriens Matteo Rossi Marta Aguirre Vazquez Thomas Vanwelden François Chesnais Adil El Taghdouini Mustapha Najimi Etienne Sokal David Cassiman Jan Snoeys Mario Monshouwer Wei-Shou Hu Christian Lange Peter Carmeliet Sarah-Maria Fendt Catherine M. Verfaillie
author_facet	Ruben Boon Manoj Kumar Tine Tricot Ilaria Elia Laura Ordovas Frank Jacobs Jennifer One Jonathan De Smedt Guy Eelen Matthew Bird Philip Roelandt Ginevra Doglioni Kim Vriens Matteo Rossi Marta Aguirre Vazquez Thomas Vanwelden François Chesnais Adil El Taghdouini Mustapha Najimi Etienne Sokal David Cassiman Jan Snoeys Mario Monshouwer Wei-Shou Hu Christian Lange Peter Carmeliet Sarah-Maria Fendt Catherine M. Verfaillie
author_sort	Ruben Boon
title	Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines
title_short	Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines
title_full	Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines
title_fullStr	Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines
title_full_unstemmed	Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines
title_sort	amino acid levels determine metabolism and cyp450 function of hepatocytes and hepatoma cell lines
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0a789642bd074590a245141b427513bf
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Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines

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