The Role of Vitamin D in Early Knee Osteoarthritis and Its Relationship with Their Physical and Psychological Status

Osteoarthritis (OA) is a common joint condition and one of the greatest causes of disability worldwide. The role of vitamin D in the origin and development of the disease is not clear, although it could have important implications for diagnosis and treatment. For this proposal, a cross-sectional stu...

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Autores principales:	Ana Alabajos-Cea, Luz Herrero-Manley, Luis Suso-Martí, Enrique Viosca-Herrero, Ferran Cuenca-Martínez, Clovis Varangot-Reille, María Blanco-Díaz, Joaquín Calatayud, José Casaña
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	osteoarthritis early osteoarthritis vitamin D Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/0a7a199e83d7429a8f32c2d1d7b84f65
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spelling	oai:doaj.org-article:0a7a199e83d7429a8f32c2d1d7b84f652021-11-25T18:36:16ZThe Role of Vitamin D in Early Knee Osteoarthritis and Its Relationship with Their Physical and Psychological Status10.3390/nu131140352072-6643https://doaj.org/article/0a7a199e83d7429a8f32c2d1d7b84f652021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4035https://doaj.org/toc/2072-6643Osteoarthritis (OA) is a common joint condition and one of the greatest causes of disability worldwide. The role of vitamin D in the origin and development of the disease is not clear, although it could have important implications for diagnosis and treatment. For this proposal, a cross-sectional study with a non-probabilistic sample was performed. In total, 48 with early osteoarthritis (EOA) and 48 matched controls were selected, and serum 25(OH)D and parathyroid hormone (PTH) levels were analyzed. In addition, physical and psychological variables were measured to establish their relationship with vitamin D levels. Patients with EOA showed lower levels (22.3 ± 7.3 ng/mL) in comparison to matched controls (29.31 ± 9.2 ng/mL). A statistically significant higher number (Chi-squared = 8.525; <i>p</i> = 0.004) of patients with EOA had deficiency levels (<20 ng/mL) compared to the control group. Patients with lower vitamin D levels showed higher levels of pain intensity, disability, and anxiety, as well as poorer values for sit-to-stand, walking speed, and social participation. Correlation analysis showed a relationship between serum 25(OH)D, PTH and pain intensity, and social participation. These results highlight the relevance of vitamin D in the early diagnosis and prevention of EOA.Ana Alabajos-CeaLuz Herrero-ManleyLuis Suso-MartíEnrique Viosca-HerreroFerran Cuenca-MartínezClovis Varangot-ReilleMaría Blanco-DíazJoaquín CalatayudJosé CasañaMDPI AGarticleosteoarthritisearly osteoarthritisvitamin DNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4035, p 4035 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteoarthritis early osteoarthritis vitamin D Nutrition. Foods and food supply TX341-641
spellingShingle	osteoarthritis early osteoarthritis vitamin D Nutrition. Foods and food supply TX341-641 Ana Alabajos-Cea Luz Herrero-Manley Luis Suso-Martí Enrique Viosca-Herrero Ferran Cuenca-Martínez Clovis Varangot-Reille María Blanco-Díaz Joaquín Calatayud José Casaña The Role of Vitamin D in Early Knee Osteoarthritis and Its Relationship with Their Physical and Psychological Status
description	Osteoarthritis (OA) is a common joint condition and one of the greatest causes of disability worldwide. The role of vitamin D in the origin and development of the disease is not clear, although it could have important implications for diagnosis and treatment. For this proposal, a cross-sectional study with a non-probabilistic sample was performed. In total, 48 with early osteoarthritis (EOA) and 48 matched controls were selected, and serum 25(OH)D and parathyroid hormone (PTH) levels were analyzed. In addition, physical and psychological variables were measured to establish their relationship with vitamin D levels. Patients with EOA showed lower levels (22.3 ± 7.3 ng/mL) in comparison to matched controls (29.31 ± 9.2 ng/mL). A statistically significant higher number (Chi-squared = 8.525; <i>p</i> = 0.004) of patients with EOA had deficiency levels (<20 ng/mL) compared to the control group. Patients with lower vitamin D levels showed higher levels of pain intensity, disability, and anxiety, as well as poorer values for sit-to-stand, walking speed, and social participation. Correlation analysis showed a relationship between serum 25(OH)D, PTH and pain intensity, and social participation. These results highlight the relevance of vitamin D in the early diagnosis and prevention of EOA.
format	article
author	Ana Alabajos-Cea Luz Herrero-Manley Luis Suso-Martí Enrique Viosca-Herrero Ferran Cuenca-Martínez Clovis Varangot-Reille María Blanco-Díaz Joaquín Calatayud José Casaña
author_facet	Ana Alabajos-Cea Luz Herrero-Manley Luis Suso-Martí Enrique Viosca-Herrero Ferran Cuenca-Martínez Clovis Varangot-Reille María Blanco-Díaz Joaquín Calatayud José Casaña
author_sort	Ana Alabajos-Cea
title	The Role of Vitamin D in Early Knee Osteoarthritis and Its Relationship with Their Physical and Psychological Status
title_short	The Role of Vitamin D in Early Knee Osteoarthritis and Its Relationship with Their Physical and Psychological Status
title_full	The Role of Vitamin D in Early Knee Osteoarthritis and Its Relationship with Their Physical and Psychological Status
title_fullStr	The Role of Vitamin D in Early Knee Osteoarthritis and Its Relationship with Their Physical and Psychological Status
title_full_unstemmed	The Role of Vitamin D in Early Knee Osteoarthritis and Its Relationship with Their Physical and Psychological Status
title_sort	role of vitamin d in early knee osteoarthritis and its relationship with their physical and psychological status
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0a7a199e83d7429a8f32c2d1d7b84f65
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The Role of Vitamin D in Early Knee Osteoarthritis and Its Relationship with Their Physical and Psychological Status

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