Hypoxia-active nanoparticles used in tumor theranostic

Yaqin Wang,1,2,* Wenting Shang,2,* Meng Niu,1 Jie Tian,2,3 Ke Xu11Department of Interventional Radiology, The First Affiliated Hospital of China Medical University, Shenyang, People’s Republic of China; 2Chinese Academy of Sciences Key Laboratory of Molecular Imaging, Institute of Automati...

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Autores principales:	Wang Y, Shang W, Niu M, Tian J, Xu K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	prodrug tumor microenvironment metal complex bio-reductive Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0a7faf8af2e448eca941ebe53cc6a5a4
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spelling	oai:doaj.org-article:0a7faf8af2e448eca941ebe53cc6a5a42021-12-02T06:16:26ZHypoxia-active nanoparticles used in tumor theranostic1178-2013https://doaj.org/article/0a7faf8af2e448eca941ebe53cc6a5a42019-05-01T00:00:00Zhttps://www.dovepress.com/hypoxia-active-nanoparticles-used-in-tumor-theranostic-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yaqin Wang,1,2,* Wenting Shang,2,* Meng Niu,1 Jie Tian,2,3 Ke Xu11Department of Interventional Radiology, The First Affiliated Hospital of China Medical University, Shenyang, People’s Republic of China; 2Chinese Academy of Sciences Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China; 3Institute of Medical Interdisciplinary Innovation, Beihang University, Beijing, 100080, People’s Republic of China*These authors contributed equally to this workAbstract: Hypoxia is a hallmark of malignant tumors and often correlates with increasing tumor aggressiveness and poor treatment outcomes. Therefore, early diagnosis and effective killing of hypoxic tumor cells are crucial for successful tumor control. There has been a surge of interdisciplinary research aimed at developing functional molecules and nanomaterials that can be used to noninvasively image and efficiently treat hypoxic tumors. These mainly include hypoxia-active nanoparticles, anti-hypoxia agents, and agents that target biomarkers of tumor hypoxia. Hypoxia-active nanoparticles have been intensively investigated and have demonstrated advanced effects on targeting tumor hypoxia. In this review, we present an overview of the reports published to date on hypoxia-activated prodrugs and their nanoparticle forms used in tumor-targeted therapy. Hypoxia-responsive nanoparticles are inactive during blood circulation and normal physiological conditions but are activated by hypoxia once they extravasate into the hypoxic tumor microenvironment. Their use can enhance the efficiency of tumor chemotherapy, radiotherapy, fluorescence and photoacoustic intensity, and other imaging and therapeutic strategies. By targeting the broad habitats of tumors, rather than tumor-specific receptors, this strategy has the potential to overcome the problem of tumor heterogeneity and could be used to design diagnostic and therapeutic nanoparticles for a broad range of solid tumors.Keywords: prodrug, tumor microenvironment, metal complex, bioreductiveWang YShang WNiu MTian JXu KDove Medical Pressarticleprodrugtumor microenvironmentmetal complexbio-reductiveMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 3705-3722 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	prodrug tumor microenvironment metal complex bio-reductive Medicine (General) R5-920
spellingShingle	prodrug tumor microenvironment metal complex bio-reductive Medicine (General) R5-920 Wang Y Shang W Niu M Tian J Xu K Hypoxia-active nanoparticles used in tumor theranostic
description	Yaqin Wang,1,2,* Wenting Shang,2,* Meng Niu,1 Jie Tian,2,3 Ke Xu11Department of Interventional Radiology, The First Affiliated Hospital of China Medical University, Shenyang, People’s Republic of China; 2Chinese Academy of Sciences Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China; 3Institute of Medical Interdisciplinary Innovation, Beihang University, Beijing, 100080, People’s Republic of China*These authors contributed equally to this workAbstract: Hypoxia is a hallmark of malignant tumors and often correlates with increasing tumor aggressiveness and poor treatment outcomes. Therefore, early diagnosis and effective killing of hypoxic tumor cells are crucial for successful tumor control. There has been a surge of interdisciplinary research aimed at developing functional molecules and nanomaterials that can be used to noninvasively image and efficiently treat hypoxic tumors. These mainly include hypoxia-active nanoparticles, anti-hypoxia agents, and agents that target biomarkers of tumor hypoxia. Hypoxia-active nanoparticles have been intensively investigated and have demonstrated advanced effects on targeting tumor hypoxia. In this review, we present an overview of the reports published to date on hypoxia-activated prodrugs and their nanoparticle forms used in tumor-targeted therapy. Hypoxia-responsive nanoparticles are inactive during blood circulation and normal physiological conditions but are activated by hypoxia once they extravasate into the hypoxic tumor microenvironment. Their use can enhance the efficiency of tumor chemotherapy, radiotherapy, fluorescence and photoacoustic intensity, and other imaging and therapeutic strategies. By targeting the broad habitats of tumors, rather than tumor-specific receptors, this strategy has the potential to overcome the problem of tumor heterogeneity and could be used to design diagnostic and therapeutic nanoparticles for a broad range of solid tumors.Keywords: prodrug, tumor microenvironment, metal complex, bioreductive
format	article
author	Wang Y Shang W Niu M Tian J Xu K
author_facet	Wang Y Shang W Niu M Tian J Xu K
author_sort	Wang Y
title	Hypoxia-active nanoparticles used in tumor theranostic
title_short	Hypoxia-active nanoparticles used in tumor theranostic
title_full	Hypoxia-active nanoparticles used in tumor theranostic
title_fullStr	Hypoxia-active nanoparticles used in tumor theranostic
title_full_unstemmed	Hypoxia-active nanoparticles used in tumor theranostic
title_sort	hypoxia-active nanoparticles used in tumor theranostic
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/0a7faf8af2e448eca941ebe53cc6a5a4
work_keys_str_mv	AT wangy hypoxiaactivenanoparticlesusedintumortheranostic AT shangw hypoxiaactivenanoparticlesusedintumortheranostic AT nium hypoxiaactivenanoparticlesusedintumortheranostic AT tianj hypoxiaactivenanoparticlesusedintumortheranostic AT xuk hypoxiaactivenanoparticlesusedintumortheranostic
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Hypoxia-active nanoparticles used in tumor theranostic

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