Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy

Through three-dimensional CRISPR screening, He et al. report that functional inhibition of BET family of proteins BRD2/3/4 shows mitigating effects on blood endothelial cell (EC) survival and/or proliferation upon VEGFA blockade. An interaction between epigenetic regulation and anti-angiogenesis, wh...

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Autores principales:	Michael Y. He, Michael M. Halford, Ruofei Liu, James P. Roy, Zoe L. Grant, Leigh Coultas, Niko Thio, Omer Gilan, Yih-Chih Chan, Mark A. Dawson, Marc G. Achen, Steven A. Stacker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0a802170899b49c7b97c4550e22321e7
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spelling	oai:doaj.org-article:0a802170899b49c7b97c4550e22321e72021-12-02T16:14:15ZThree-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy10.1038/s42003-021-02397-32399-3642https://doaj.org/article/0a802170899b49c7b97c4550e22321e72021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02397-3https://doaj.org/toc/2399-3642Through three-dimensional CRISPR screening, He et al. report that functional inhibition of BET family of proteins BRD2/3/4 shows mitigating effects on blood endothelial cell (EC) survival and/or proliferation upon VEGFA blockade. An interaction between epigenetic regulation and anti-angiogenesis, which may affect chromosomal structure and activity in ECs through CDC25B phosphatase, is potentially involved with EC resistance to anti-angiogenic therapy.Michael Y. HeMichael M. HalfordRuofei LiuJames P. RoyZoe L. GrantLeigh CoultasNiko ThioOmer GilanYih-Chih ChanMark A. DawsonMarc G. AchenSteven A. StackerNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Michael Y. He Michael M. Halford Ruofei Liu James P. Roy Zoe L. Grant Leigh Coultas Niko Thio Omer Gilan Yih-Chih Chan Mark A. Dawson Marc G. Achen Steven A. Stacker Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy
description	Through three-dimensional CRISPR screening, He et al. report that functional inhibition of BET family of proteins BRD2/3/4 shows mitigating effects on blood endothelial cell (EC) survival and/or proliferation upon VEGFA blockade. An interaction between epigenetic regulation and anti-angiogenesis, which may affect chromosomal structure and activity in ECs through CDC25B phosphatase, is potentially involved with EC resistance to anti-angiogenic therapy.
format	article
author	Michael Y. He Michael M. Halford Ruofei Liu James P. Roy Zoe L. Grant Leigh Coultas Niko Thio Omer Gilan Yih-Chih Chan Mark A. Dawson Marc G. Achen Steven A. Stacker
author_facet	Michael Y. He Michael M. Halford Ruofei Liu James P. Roy Zoe L. Grant Leigh Coultas Niko Thio Omer Gilan Yih-Chih Chan Mark A. Dawson Marc G. Achen Steven A. Stacker
author_sort	Michael Y. He
title	Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy
title_short	Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy
title_full	Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy
title_fullStr	Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy
title_full_unstemmed	Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy
title_sort	three-dimensional crispr screening reveals epigenetic interaction with anti-angiogenic therapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0a802170899b49c7b97c4550e22321e7
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Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy

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