A prospective, observational clinical trial on the impact of COVID-19-related national lockdown on thyroid hormone in young males

Abstract Trying to manage the dramatic coronavirus disease 2019 (COVID-19) infection spread, many countries imposed national lockdown, radically changing the routinely life of humans worldwide. We hypothesized that both the pandemic per se and the consequent socio-psychological sequelae could consti...

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Autores principales:	Giulia Brigante, Giorgia Spaggiari, Barbara Rossi, Antonio Granata, Manuela Simoni, Daniele Santi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0a8174b496cb4a8cb1d188f251bbf3d8
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spelling	oai:doaj.org-article:0a8174b496cb4a8cb1d188f251bbf3d82021-12-02T14:25:21ZA prospective, observational clinical trial on the impact of COVID-19-related national lockdown on thyroid hormone in young males10.1038/s41598-021-86670-92045-2322https://doaj.org/article/0a8174b496cb4a8cb1d188f251bbf3d82021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86670-9https://doaj.org/toc/2045-2322Abstract Trying to manage the dramatic coronavirus disease 2019 (COVID-19) infection spread, many countries imposed national lockdown, radically changing the routinely life of humans worldwide. We hypothesized that both the pandemic per se and the consequent socio-psychological sequelae could constitute stressors for Italian population, potentially affecting the endocrine system. This study was designed to describe the effect of lockdown-related stress on the hypothalamic-pituitary-thyroid (HPT) axis in a cohort of young men. A prospective, observational clinical trial was carried out, including patients attending the male infertility outpatient clinic before and after the national lockdown for COVID-19 pandemic. The study provided a baseline visit performed before and a follow-up visit after the lockdown in 2020. During the follow-up visit, hormonal measurements, lifestyle habits and work management were recorded. Thirty-one male subjects were enrolled (mean age: 31.6 ± 6.0 years). TSH significantly decreased after lockdown (p = 0.015), whereas no significant changes were observed in the testosterone, luteinising hormone, follicle-stimulating hormone, estradiol and prolactin serum levels. No patient showed TSH serum levels above or below reference ranges, neither before nor after lockdown. Interestingly, TSH variation after lockdown was dependent on the working habit change during lockdown (p = 0.042). We described for the first time a TSH reduction after a stressful event in a prospective way, evaluating the HPT axis in the same population, before and after the national lockdown. This result reinforces the possible interconnection between psychological consequences of a stressful event and the endocrine regulation.Giulia BriganteGiorgia SpaggiariBarbara RossiAntonio GranataManuela SimoniDaniele SantiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giulia Brigante Giorgia Spaggiari Barbara Rossi Antonio Granata Manuela Simoni Daniele Santi A prospective, observational clinical trial on the impact of COVID-19-related national lockdown on thyroid hormone in young males
description	Abstract Trying to manage the dramatic coronavirus disease 2019 (COVID-19) infection spread, many countries imposed national lockdown, radically changing the routinely life of humans worldwide. We hypothesized that both the pandemic per se and the consequent socio-psychological sequelae could constitute stressors for Italian population, potentially affecting the endocrine system. This study was designed to describe the effect of lockdown-related stress on the hypothalamic-pituitary-thyroid (HPT) axis in a cohort of young men. A prospective, observational clinical trial was carried out, including patients attending the male infertility outpatient clinic before and after the national lockdown for COVID-19 pandemic. The study provided a baseline visit performed before and a follow-up visit after the lockdown in 2020. During the follow-up visit, hormonal measurements, lifestyle habits and work management were recorded. Thirty-one male subjects were enrolled (mean age: 31.6 ± 6.0 years). TSH significantly decreased after lockdown (p = 0.015), whereas no significant changes were observed in the testosterone, luteinising hormone, follicle-stimulating hormone, estradiol and prolactin serum levels. No patient showed TSH serum levels above or below reference ranges, neither before nor after lockdown. Interestingly, TSH variation after lockdown was dependent on the working habit change during lockdown (p = 0.042). We described for the first time a TSH reduction after a stressful event in a prospective way, evaluating the HPT axis in the same population, before and after the national lockdown. This result reinforces the possible interconnection between psychological consequences of a stressful event and the endocrine regulation.
format	article
author	Giulia Brigante Giorgia Spaggiari Barbara Rossi Antonio Granata Manuela Simoni Daniele Santi
author_facet	Giulia Brigante Giorgia Spaggiari Barbara Rossi Antonio Granata Manuela Simoni Daniele Santi
author_sort	Giulia Brigante
title	A prospective, observational clinical trial on the impact of COVID-19-related national lockdown on thyroid hormone in young males
title_short	A prospective, observational clinical trial on the impact of COVID-19-related national lockdown on thyroid hormone in young males
title_full	A prospective, observational clinical trial on the impact of COVID-19-related national lockdown on thyroid hormone in young males
title_fullStr	A prospective, observational clinical trial on the impact of COVID-19-related national lockdown on thyroid hormone in young males
title_full_unstemmed	A prospective, observational clinical trial on the impact of COVID-19-related national lockdown on thyroid hormone in young males
title_sort	prospective, observational clinical trial on the impact of covid-19-related national lockdown on thyroid hormone in young males
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0a8174b496cb4a8cb1d188f251bbf3d8
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A prospective, observational clinical trial on the impact of COVID-19-related national lockdown on thyroid hormone in young males

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