Preclinical Evaluations To Identify Optimal Linezolid Regimens for Tuberculosis Therapy
ABSTRACT Linezolid is an oxazolidinone with potent activity against Mycobacterium tuberculosis. Linezolid toxicity in patients correlates with the dose and duration of therapy. These toxicities are attributable to the inhibition of mitochondrial protein synthesis. Clinically relevant linezolid regim...
Guardado en:
Autores principales: | Ashley N. Brown, George L. Drusano, Jonathan R. Adams, Jaime L. Rodriquez, Kalyani Jambunathan, Dodge L. Baluya, David L. Brown, Awewura Kwara, Jon C. Mirsalis, Richard Hafner, Arnold Louie |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
American Society for Microbiology
2015
|
Materias: | |
Acceso en línea: | https://doaj.org/article/0a8207688af7408c9f377cb7543d327b |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Analysis of combination drug therapy to develop regimens with shortened duration of treatment for tuberculosis.
por: George L Drusano, et al.
Publicado: (2014) -
The Combination of Rifampin plus Moxifloxacin Is Synergistic for Suppression of Resistance but Antagonistic for Cell Kill of <italic toggle="yes">Mycobacterium tuberculosis</italic> as Determined in a Hollow-Fiber Infection Model
por: G. L. Drusano, et al.
Publicado: (2010) -
Effect of Administration of Moxifloxacin plus Rifampin against <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> for 7 of 7 Days versus 5 of 7 Days in an <italic toggle="yes">In Vitro</italic> Pharmacodynamic System
por: G. L. Drusano, et al.
Publicado: (2011) -
Impact of smear-negative results on tuberculosis outcome in HIV co-infected patients at a teaching hospital in Ghana
por: Jeremy Mudd, et al.
Publicado: (2016) -
Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy.
por: Josep M Sierra, et al.
Publicado: (2013)