Mutant KRAS promotes malignant pleural effusion formation

Malignant pleural effusion (MPE) is a lethal condition associated with various cancers. Here, the authors show that cancer cells withKRASmutations promote MPE by recruiting myeloid cells via CCL2 signalling and that pharmaceutical targeting of KRAS results in reduced MPE incidence and volume in mous...

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Autores principales:	Theodora Agalioti, Anastasios D. Giannou, Anthi C. Krontira, Nikolaos I. Kanellakis, Danai Kati, Malamati Vreka, Mario Pepe, Magda Spella, Ioannis Lilis, Dimitra E. Zazara, Eirini Nikolouli, Nikolitsa Spiropoulou, Andreas Papadakis, Konstantina Papadia, Apostolos Voulgaridis, Vaggelis Harokopos, Panagiota Stamou, Silke Meiners, Oliver Eickelberg, Linda A. Snyder, Sophia G. Antimisiaris, Dimitrios Kardamakis, Ioannis Psallidas, Antonia Marazioti, Georgios T. Stathopoulos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0a878d637c6749f7a229ddbc89117bed
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spelling	oai:doaj.org-article:0a878d637c6749f7a229ddbc89117bed2021-12-02T17:01:16ZMutant KRAS promotes malignant pleural effusion formation10.1038/ncomms152052041-1723https://doaj.org/article/0a878d637c6749f7a229ddbc89117bed2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15205https://doaj.org/toc/2041-1723Malignant pleural effusion (MPE) is a lethal condition associated with various cancers. Here, the authors show that cancer cells withKRASmutations promote MPE by recruiting myeloid cells via CCL2 signalling and that pharmaceutical targeting of KRAS results in reduced MPE incidence and volume in mouse models.Theodora AgaliotiAnastasios D. GiannouAnthi C. KrontiraNikolaos I. KanellakisDanai KatiMalamati VrekaMario PepeMagda SpellaIoannis LilisDimitra E. ZazaraEirini NikolouliNikolitsa SpiropoulouAndreas PapadakisKonstantina PapadiaApostolos VoulgaridisVaggelis HarokoposPanagiota StamouSilke MeinersOliver EickelbergLinda A. SnyderSophia G. AntimisiarisDimitrios KardamakisIoannis PsallidasAntonia MaraziotiGeorgios T. StathopoulosNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Theodora Agalioti Anastasios D. Giannou Anthi C. Krontira Nikolaos I. Kanellakis Danai Kati Malamati Vreka Mario Pepe Magda Spella Ioannis Lilis Dimitra E. Zazara Eirini Nikolouli Nikolitsa Spiropoulou Andreas Papadakis Konstantina Papadia Apostolos Voulgaridis Vaggelis Harokopos Panagiota Stamou Silke Meiners Oliver Eickelberg Linda A. Snyder Sophia G. Antimisiaris Dimitrios Kardamakis Ioannis Psallidas Antonia Marazioti Georgios T. Stathopoulos Mutant KRAS promotes malignant pleural effusion formation
description	Malignant pleural effusion (MPE) is a lethal condition associated with various cancers. Here, the authors show that cancer cells withKRASmutations promote MPE by recruiting myeloid cells via CCL2 signalling and that pharmaceutical targeting of KRAS results in reduced MPE incidence and volume in mouse models.
format	article
author	Theodora Agalioti Anastasios D. Giannou Anthi C. Krontira Nikolaos I. Kanellakis Danai Kati Malamati Vreka Mario Pepe Magda Spella Ioannis Lilis Dimitra E. Zazara Eirini Nikolouli Nikolitsa Spiropoulou Andreas Papadakis Konstantina Papadia Apostolos Voulgaridis Vaggelis Harokopos Panagiota Stamou Silke Meiners Oliver Eickelberg Linda A. Snyder Sophia G. Antimisiaris Dimitrios Kardamakis Ioannis Psallidas Antonia Marazioti Georgios T. Stathopoulos
author_facet	Theodora Agalioti Anastasios D. Giannou Anthi C. Krontira Nikolaos I. Kanellakis Danai Kati Malamati Vreka Mario Pepe Magda Spella Ioannis Lilis Dimitra E. Zazara Eirini Nikolouli Nikolitsa Spiropoulou Andreas Papadakis Konstantina Papadia Apostolos Voulgaridis Vaggelis Harokopos Panagiota Stamou Silke Meiners Oliver Eickelberg Linda A. Snyder Sophia G. Antimisiaris Dimitrios Kardamakis Ioannis Psallidas Antonia Marazioti Georgios T. Stathopoulos
author_sort	Theodora Agalioti
title	Mutant KRAS promotes malignant pleural effusion formation
title_short	Mutant KRAS promotes malignant pleural effusion formation
title_full	Mutant KRAS promotes malignant pleural effusion formation
title_fullStr	Mutant KRAS promotes malignant pleural effusion formation
title_full_unstemmed	Mutant KRAS promotes malignant pleural effusion formation
title_sort	mutant kras promotes malignant pleural effusion formation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0a878d637c6749f7a229ddbc89117bed
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Mutant KRAS promotes malignant pleural effusion formation

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