Large subgaleal hematoma caused by valproic acid: a case report

Introdução: Valproic acid (VPA), used to treat epilepsy, may present hematological abnormalities as complications. One such example is bleeding associated with trauma. We herein report a case about large subgaleal hemorrhage that occurred after a mild head trauma in a child following VPA administrat...

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Autores principales:	Aldo José F da Silva, Ana Carolina Ruela Carvalho, Fabiana Lopes Amaral, Auxiliadora Damiane Pereira Vieira da Costa
Formato:	article
Lenguaje:	EN
Publicado:	Brazilian Society for Pediatric Neurosurgery 2020
Materias:	valproic acid rett syndrome hematoma epilepsy thrombocytopenia Pediatrics RJ1-570 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/0a8915f3f1814623b8ae5a76e46058f9
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spelling	oai:doaj.org-article:0a8915f3f1814623b8ae5a76e46058f92021-11-23T21:46:36ZLarge subgaleal hematoma caused by valproic acid: a case report2675-362610.46900/apn.v2i3(September-December).53https://doaj.org/article/0a8915f3f1814623b8ae5a76e46058f92020-12-01T00:00:00Zhttps://www.archpedneurosurg.com.br/pkp/index.php/sbnped2019/article/view/53https://doaj.org/toc/2675-3626Introdução: Valproic acid (VPA), used to treat epilepsy, may present hematological abnormalities as complications. One such example is bleeding associated with trauma. We herein report a case about large subgaleal hemorrhage that occurred after a mild head trauma in a child following VPA administration. Case Report: A 12-year-old female child diagnosed with Rett Syndrome had difficulty in controlling epilepsy and was taking 50 mg/kg/day VPA. After suffering from a mild head trauma, a large subgaleal hematoma was evidenced on Computed Tomography(CT) scan of head. Surgical intervention was performed, with drainage of the hematoma, and the patient showed progression. Discussion: The incidence of coagulopathy related to VPA is 4%, and thrombocytopenia is the most common coagulation disorder. Hemorrhagic complications can occur regardless of the plasma levels or duration of treatment. In VPA therapy, the side effects should be considered, particularly hematological abnormalities. In our case, an unusual hemorrhagic complication (subgaleal hematoma) was reported, with good surgical resolution of the pathology.Aldo José F da SilvaAna Carolina Ruela CarvalhoFabiana Lopes AmaralAuxiliadora Damiane Pereira Vieira da CostaBrazilian Society for Pediatric Neurosurgeryarticlevalproic acidrett syndromehematomaepilepsythrombocytopeniaPediatricsRJ1-570SurgeryRD1-811ENArchives of Pediatric Neurosurgery, Vol 2, Iss 3(September-December) (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	valproic acid rett syndrome hematoma epilepsy thrombocytopenia Pediatrics RJ1-570 Surgery RD1-811
spellingShingle	valproic acid rett syndrome hematoma epilepsy thrombocytopenia Pediatrics RJ1-570 Surgery RD1-811 Aldo José F da Silva Ana Carolina Ruela Carvalho Fabiana Lopes Amaral Auxiliadora Damiane Pereira Vieira da Costa Large subgaleal hematoma caused by valproic acid: a case report
description	Introdução: Valproic acid (VPA), used to treat epilepsy, may present hematological abnormalities as complications. One such example is bleeding associated with trauma. We herein report a case about large subgaleal hemorrhage that occurred after a mild head trauma in a child following VPA administration. Case Report: A 12-year-old female child diagnosed with Rett Syndrome had difficulty in controlling epilepsy and was taking 50 mg/kg/day VPA. After suffering from a mild head trauma, a large subgaleal hematoma was evidenced on Computed Tomography(CT) scan of head. Surgical intervention was performed, with drainage of the hematoma, and the patient showed progression. Discussion: The incidence of coagulopathy related to VPA is 4%, and thrombocytopenia is the most common coagulation disorder. Hemorrhagic complications can occur regardless of the plasma levels or duration of treatment. In VPA therapy, the side effects should be considered, particularly hematological abnormalities. In our case, an unusual hemorrhagic complication (subgaleal hematoma) was reported, with good surgical resolution of the pathology.
format	article
author	Aldo José F da Silva Ana Carolina Ruela Carvalho Fabiana Lopes Amaral Auxiliadora Damiane Pereira Vieira da Costa
author_facet	Aldo José F da Silva Ana Carolina Ruela Carvalho Fabiana Lopes Amaral Auxiliadora Damiane Pereira Vieira da Costa
author_sort	Aldo José F da Silva
title	Large subgaleal hematoma caused by valproic acid: a case report
title_short	Large subgaleal hematoma caused by valproic acid: a case report
title_full	Large subgaleal hematoma caused by valproic acid: a case report
title_fullStr	Large subgaleal hematoma caused by valproic acid: a case report
title_full_unstemmed	Large subgaleal hematoma caused by valproic acid: a case report
title_sort	large subgaleal hematoma caused by valproic acid: a case report
publisher	Brazilian Society for Pediatric Neurosurgery
publishDate	2020
url	https://doaj.org/article/0a8915f3f1814623b8ae5a76e46058f9
work_keys_str_mv	AT aldojosefdasilva largesubgalealhematomacausedbyvalproicacidacasereport AT anacarolinaruelacarvalho largesubgalealhematomacausedbyvalproicacidacasereport AT fabianalopesamaral largesubgalealhematomacausedbyvalproicacidacasereport AT auxiliadoradamianepereiravieiradacosta largesubgalealhematomacausedbyvalproicacidacasereport
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Large subgaleal hematoma caused by valproic acid: a case report

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