Leukocyte telomere length in HIV-infected and HIV-exposed uninfected children: shorter telomeres with uncontrolled HIV viremia.
<h4>Objectives</h4>Nucleoside reverse transcriptase inhibitors (NRTIs) used in HIV antiretroviral therapy can inhibit human telomerase reverse transcriptase. We therefore investigated whether in utero or childhood exposure to NRTIs affects leukocyte telomere length (LTL), a marker of cel...
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oai:doaj.org-article:0a8923aa0732451c923996110afab9292021-11-18T07:12:29ZLeukocyte telomere length in HIV-infected and HIV-exposed uninfected children: shorter telomeres with uncontrolled HIV viremia.1932-620310.1371/journal.pone.0039266https://doaj.org/article/0a8923aa0732451c923996110afab9292012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22815702/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>Nucleoside reverse transcriptase inhibitors (NRTIs) used in HIV antiretroviral therapy can inhibit human telomerase reverse transcriptase. We therefore investigated whether in utero or childhood exposure to NRTIs affects leukocyte telomere length (LTL), a marker of cellular aging.<h4>Methods</h4>In this cross-sectional CARMA cohort study, we investigated factors associated with LTL in HIV-1-infected (HIV(+)) children (n = 94), HIV-1-exposed uninfected (HEU) children who were exposed to antiretroviral therapy (ART) perinatally (n = 177), and HIV-unexposed uninfected (HIV(-)) control children (n = 104) aged 0-19 years. Univariate followed by multivariate linear regression models were used to examine relationships of explanatory variables with LTL for: a) all subjects, b) HIV(+)/HEU children only, and c) HIV(+) children only.<h4>Results</h4>After adjusting for age and gender, there was no difference in LTL between the 3 groups, when considering children of all ages together. In multivariate models, older age and male gender were associated with shorter LTL. For the HIV(+) group alone, having a detectable HIV viral load was also strongly associated with shorter LTL (p = 0.007).<h4>Conclusions</h4>In this large study, group rates of LTL attrition were similar for HIV(+), HEU and HIV(-) children. No associations between children's LTL and their perinatal ART exposure or HIV status were seen in linear regression models. However, the association between having a detectable HIV viral load and shorter LTL suggests that uncontrolled HIV viremia rather than duration of ART exposure may be associated with acceleration of blood telomere attrition.Hélène C F CôtéHugo SoudeynsAnona ThorneAriane AlimentiValérie LamarreEvelyn J MaanBeheroze SatthaJoel SingerNormand LapointeDeborah M MoneyJohn ForbesCIHR Emerging Team in HIV therapy, aging (CARMA)Judy WongAri BitnunLindy SamsonJason BrophyDavid BurdgeNeora PickJulie van SchalkwykJulio MontanerMarianne HarrisPatti JanssenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e39266 (2012) |
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Medicine R Science Q Hélène C F Côté Hugo Soudeyns Anona Thorne Ariane Alimenti Valérie Lamarre Evelyn J Maan Beheroze Sattha Joel Singer Normand Lapointe Deborah M Money John Forbes CIHR Emerging Team in HIV therapy, aging (CARMA) Judy Wong Ari Bitnun Lindy Samson Jason Brophy David Burdge Neora Pick Julie van Schalkwyk Julio Montaner Marianne Harris Patti Janssen Leukocyte telomere length in HIV-infected and HIV-exposed uninfected children: shorter telomeres with uncontrolled HIV viremia. |
| description |
<h4>Objectives</h4>Nucleoside reverse transcriptase inhibitors (NRTIs) used in HIV antiretroviral therapy can inhibit human telomerase reverse transcriptase. We therefore investigated whether in utero or childhood exposure to NRTIs affects leukocyte telomere length (LTL), a marker of cellular aging.<h4>Methods</h4>In this cross-sectional CARMA cohort study, we investigated factors associated with LTL in HIV-1-infected (HIV(+)) children (n = 94), HIV-1-exposed uninfected (HEU) children who were exposed to antiretroviral therapy (ART) perinatally (n = 177), and HIV-unexposed uninfected (HIV(-)) control children (n = 104) aged 0-19 years. Univariate followed by multivariate linear regression models were used to examine relationships of explanatory variables with LTL for: a) all subjects, b) HIV(+)/HEU children only, and c) HIV(+) children only.<h4>Results</h4>After adjusting for age and gender, there was no difference in LTL between the 3 groups, when considering children of all ages together. In multivariate models, older age and male gender were associated with shorter LTL. For the HIV(+) group alone, having a detectable HIV viral load was also strongly associated with shorter LTL (p = 0.007).<h4>Conclusions</h4>In this large study, group rates of LTL attrition were similar for HIV(+), HEU and HIV(-) children. No associations between children's LTL and their perinatal ART exposure or HIV status were seen in linear regression models. However, the association between having a detectable HIV viral load and shorter LTL suggests that uncontrolled HIV viremia rather than duration of ART exposure may be associated with acceleration of blood telomere attrition. |
| format |
article |
| author |
Hélène C F Côté Hugo Soudeyns Anona Thorne Ariane Alimenti Valérie Lamarre Evelyn J Maan Beheroze Sattha Joel Singer Normand Lapointe Deborah M Money John Forbes CIHR Emerging Team in HIV therapy, aging (CARMA) Judy Wong Ari Bitnun Lindy Samson Jason Brophy David Burdge Neora Pick Julie van Schalkwyk Julio Montaner Marianne Harris Patti Janssen |
| author_facet |
Hélène C F Côté Hugo Soudeyns Anona Thorne Ariane Alimenti Valérie Lamarre Evelyn J Maan Beheroze Sattha Joel Singer Normand Lapointe Deborah M Money John Forbes CIHR Emerging Team in HIV therapy, aging (CARMA) Judy Wong Ari Bitnun Lindy Samson Jason Brophy David Burdge Neora Pick Julie van Schalkwyk Julio Montaner Marianne Harris Patti Janssen |
| author_sort |
Hélène C F Côté |
| title |
Leukocyte telomere length in HIV-infected and HIV-exposed uninfected children: shorter telomeres with uncontrolled HIV viremia. |
| title_short |
Leukocyte telomere length in HIV-infected and HIV-exposed uninfected children: shorter telomeres with uncontrolled HIV viremia. |
| title_full |
Leukocyte telomere length in HIV-infected and HIV-exposed uninfected children: shorter telomeres with uncontrolled HIV viremia. |
| title_fullStr |
Leukocyte telomere length in HIV-infected and HIV-exposed uninfected children: shorter telomeres with uncontrolled HIV viremia. |
| title_full_unstemmed |
Leukocyte telomere length in HIV-infected and HIV-exposed uninfected children: shorter telomeres with uncontrolled HIV viremia. |
| title_sort |
leukocyte telomere length in hiv-infected and hiv-exposed uninfected children: shorter telomeres with uncontrolled hiv viremia. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/0a8923aa0732451c923996110afab929 |
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