Proresolving Lipid Mediators and Receptors in Stem Cell Biology: Concise Review

Summary Accumulating evidence indicates that stem cells (SCs) possess immunomodulatory, anti‐inflammatory, and prohealing properties. The mechanisms underlying these functions are being investigated with the final goal to set a solid background for the clinical use of SCs and/or their derivatives. S...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mario Romano, Sara Patruno, Antonella Pomilio, Antonio Recchiuti
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2019
Materias:	Medicine (General) R5-920 Cytology QH573-671
Acceso en línea:	https://doaj.org/article/0a8d424954f041c5a6dd2023fdb2fdb3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0a8d424954f041c5a6dd2023fdb2fdb3
record_format	dspace
spelling	oai:doaj.org-article:0a8d424954f041c5a6dd2023fdb2fdb32021-11-30T19:15:36ZProresolving Lipid Mediators and Receptors in Stem Cell Biology: Concise Review2157-65802157-656410.1002/sctm.19-0078https://doaj.org/article/0a8d424954f041c5a6dd2023fdb2fdb32019-10-01T00:00:00Zhttps://doi.org/10.1002/sctm.19-0078https://doaj.org/toc/2157-6564https://doaj.org/toc/2157-6580Summary Accumulating evidence indicates that stem cells (SCs) possess immunomodulatory, anti‐inflammatory, and prohealing properties. The mechanisms underlying these functions are being investigated with the final goal to set a solid background for the clinical use of SCs and/or their derivatives. Specialized proresolving lipid mediators (SPMs) are small lipids formed by the enzymatic metabolism of polyunsaturated fatty acids. They represent a leading class of molecules that actively and timely regulate the resolution of inflammation and promote tissue/organ repair. SC formation of these mediators as well as expression of their receptors has been recently reported, suggesting that SPMs may be involved in the immunomodulatory, proresolving functions of SCs. In the present review, we summarize the current knowledge on SPMs in SCs, focusing on biosynthetic pathways, receptors, and bioactions, with the intent to provide an integrated view of SPM impact on SC biology. Stem Cells Translational Medicine 2019;8:992–998Mario RomanoSara PatrunoAntonella PomilioAntonio RecchiutiWileyarticleMedicine (General)R5-920CytologyQH573-671ENStem Cells Translational Medicine, Vol 8, Iss 10, Pp 992-998 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920 Cytology QH573-671
spellingShingle	Medicine (General) R5-920 Cytology QH573-671 Mario Romano Sara Patruno Antonella Pomilio Antonio Recchiuti Proresolving Lipid Mediators and Receptors in Stem Cell Biology: Concise Review
description	Summary Accumulating evidence indicates that stem cells (SCs) possess immunomodulatory, anti‐inflammatory, and prohealing properties. The mechanisms underlying these functions are being investigated with the final goal to set a solid background for the clinical use of SCs and/or their derivatives. Specialized proresolving lipid mediators (SPMs) are small lipids formed by the enzymatic metabolism of polyunsaturated fatty acids. They represent a leading class of molecules that actively and timely regulate the resolution of inflammation and promote tissue/organ repair. SC formation of these mediators as well as expression of their receptors has been recently reported, suggesting that SPMs may be involved in the immunomodulatory, proresolving functions of SCs. In the present review, we summarize the current knowledge on SPMs in SCs, focusing on biosynthetic pathways, receptors, and bioactions, with the intent to provide an integrated view of SPM impact on SC biology. Stem Cells Translational Medicine 2019;8:992–998
format	article
author	Mario Romano Sara Patruno Antonella Pomilio Antonio Recchiuti
author_facet	Mario Romano Sara Patruno Antonella Pomilio Antonio Recchiuti
author_sort	Mario Romano
title	Proresolving Lipid Mediators and Receptors in Stem Cell Biology: Concise Review
title_short	Proresolving Lipid Mediators and Receptors in Stem Cell Biology: Concise Review
title_full	Proresolving Lipid Mediators and Receptors in Stem Cell Biology: Concise Review
title_fullStr	Proresolving Lipid Mediators and Receptors in Stem Cell Biology: Concise Review
title_full_unstemmed	Proresolving Lipid Mediators and Receptors in Stem Cell Biology: Concise Review
title_sort	proresolving lipid mediators and receptors in stem cell biology: concise review
publisher	Wiley
publishDate	2019
url	https://doaj.org/article/0a8d424954f041c5a6dd2023fdb2fdb3
work_keys_str_mv	AT marioromano proresolvinglipidmediatorsandreceptorsinstemcellbiologyconcisereview AT sarapatruno proresolvinglipidmediatorsandreceptorsinstemcellbiologyconcisereview AT antonellapomilio proresolvinglipidmediatorsandreceptorsinstemcellbiologyconcisereview AT antoniorecchiuti proresolvinglipidmediatorsandreceptorsinstemcellbiologyconcisereview
_version_	1718406304337231872

Proresolving Lipid Mediators and Receptors in Stem Cell Biology: Concise Review

Ejemplares similares