A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors

A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors

Biological polymeric matrices often use molecular anchors, such as antibodies, to trap nanoparticulates. Here, the authors find that anchor-matrix bonds that are weak and short-lived confer superior trapping potency, contrary to the prevailing belief that effective molecular anchors should form stro...

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Autores principales: Jay Newby, Jennifer L. Schiller, Timothy Wessler, Jasmine Edelstein, M. Gregory Forest, Samuel K. Lai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/0a8f61c054d7499c8cfd1b1294055ed1
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spelling oai:doaj.org-article:0a8f61c054d7499c8cfd1b1294055ed12021-12-02T15:37:06ZA blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors10.1038/s41467-017-00739-62041-1723https://doaj.org/article/0a8f61c054d7499c8cfd1b1294055ed12017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00739-6https://doaj.org/toc/2041-1723Biological polymeric matrices often use molecular anchors, such as antibodies, to trap nanoparticulates. Here, the authors find that anchor-matrix bonds that are weak and short-lived confer superior trapping potency, contrary to the prevailing belief that effective molecular anchors should form strong bonds to both the matrix and the nanoparticulates.Jay NewbyJennifer L. SchillerTimothy WesslerJasmine EdelsteinM. Gregory ForestSamuel K. LaiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jay Newby
Jennifer L. Schiller
Timothy Wessler
Jasmine Edelstein
M. Gregory Forest
Samuel K. Lai
A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors
description Biological polymeric matrices often use molecular anchors, such as antibodies, to trap nanoparticulates. Here, the authors find that anchor-matrix bonds that are weak and short-lived confer superior trapping potency, contrary to the prevailing belief that effective molecular anchors should form strong bonds to both the matrix and the nanoparticulates.
format article
author Jay Newby
Jennifer L. Schiller
Timothy Wessler
Jasmine Edelstein
M. Gregory Forest
Samuel K. Lai
author_facet Jay Newby
Jennifer L. Schiller
Timothy Wessler
Jasmine Edelstein
M. Gregory Forest
Samuel K. Lai
author_sort Jay Newby
title A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors
title_short A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors
title_full A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors
title_fullStr A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors
title_full_unstemmed A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors
title_sort blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/0a8f61c054d7499c8cfd1b1294055ed1
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