Antimicrobial resistance of bacterial isolates from respiratory secretions of ventilated patients in a multi-specialty hospital

Context: Ventilator-associated pneumonia (VAP) is a common nosocomial infection occurring in intensive care unit (ICU) settings. VAP occurs due to interplay of three factors - impaired host defense, access of large numbers of pathogenic bacteria to the lower respiratory tract and the virulence of th...

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Autores principales: Nishat Hussain Ahmed, Tabish Hussain, Indu Biswal
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Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2015
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Acceso en línea:https://doaj.org/article/0a90912d5b4449bcb403adcbbc56bb12
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spelling oai:doaj.org-article:0a90912d5b4449bcb403adcbbc56bb122021-12-02T16:24:57ZAntimicrobial resistance of bacterial isolates from respiratory secretions of ventilated patients in a multi-specialty hospital2231-07702249-446410.4103/2231-0770.160233https://doaj.org/article/0a90912d5b4449bcb403adcbbc56bb122015-07-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.4103/2231-0770.160233https://doaj.org/toc/2231-0770https://doaj.org/toc/2249-4464Context: Ventilator-associated pneumonia (VAP) is a common nosocomial infection occurring in intensive care unit (ICU) settings. VAP occurs due to interplay of three factors - impaired host defense, access of large numbers of pathogenic bacteria to the lower respiratory tract and the virulence of the organism. Knowledge of colonizing microbial flora and their antibiogram in ventilated patients is of great importance in timely institution of empirical therapy, so that mortality and morbidity due to VAP can be reduced. Subjects and Methods: A prospective study was performed over a period of 6 months in a multi-specialty hospital to determine the various pathogens in respiratory secretions and to determine the prevalence of multidrug resistance (MDR). Results: Pseudomonas aeruginosa (26%), Acinetobacter (26%), Klebsiella pneumoniae (26%), followed by Escherichia coli (15%), Staphylococcus aureus (6%) and Citrobacter spp. (1.5%) were the common pathogens isolated in our study. In all, 72.73% (48/66) bacterial isolates were isolated from medical ICU, while 25.76% (17/66) were isolated from surgical ICU. Only one strain (Acinetobacter) was isolated from pediatric ICU. Fifty-seven (86.36%) of the 66 pathogens in our study were MDR. Conclusion: There is increasing colonization of pathogenic bacteria in ventilated patients admitted in ICUs, which are predominantly MDR. These colonizers may cause infection resulting in VAP. Judicious use of antibiotics, guided by local antibiotic resistance profile coupled with strict infection control practices alongside application of VAP bundle are important measures to prevent these pathogens from causing VAP in ICU patients.Nishat Hussain AhmedTabish HussainIndu BiswalThieme Medical and Scientific Publishers Pvt. Ltd.articlemultidrug resistancepathogensventilator-associated pneumoniaMedicineRENAvicenna Journal of Medicine, Vol 05, Iss 03, Pp 74-78 (2015)
institution DOAJ
collection DOAJ
language EN
topic multidrug resistance
pathogens
ventilator-associated pneumonia
Medicine
R
spellingShingle multidrug resistance
pathogens
ventilator-associated pneumonia
Medicine
R
Nishat Hussain Ahmed
Tabish Hussain
Indu Biswal
Antimicrobial resistance of bacterial isolates from respiratory secretions of ventilated patients in a multi-specialty hospital
description Context: Ventilator-associated pneumonia (VAP) is a common nosocomial infection occurring in intensive care unit (ICU) settings. VAP occurs due to interplay of three factors - impaired host defense, access of large numbers of pathogenic bacteria to the lower respiratory tract and the virulence of the organism. Knowledge of colonizing microbial flora and their antibiogram in ventilated patients is of great importance in timely institution of empirical therapy, so that mortality and morbidity due to VAP can be reduced. Subjects and Methods: A prospective study was performed over a period of 6 months in a multi-specialty hospital to determine the various pathogens in respiratory secretions and to determine the prevalence of multidrug resistance (MDR). Results: Pseudomonas aeruginosa (26%), Acinetobacter (26%), Klebsiella pneumoniae (26%), followed by Escherichia coli (15%), Staphylococcus aureus (6%) and Citrobacter spp. (1.5%) were the common pathogens isolated in our study. In all, 72.73% (48/66) bacterial isolates were isolated from medical ICU, while 25.76% (17/66) were isolated from surgical ICU. Only one strain (Acinetobacter) was isolated from pediatric ICU. Fifty-seven (86.36%) of the 66 pathogens in our study were MDR. Conclusion: There is increasing colonization of pathogenic bacteria in ventilated patients admitted in ICUs, which are predominantly MDR. These colonizers may cause infection resulting in VAP. Judicious use of antibiotics, guided by local antibiotic resistance profile coupled with strict infection control practices alongside application of VAP bundle are important measures to prevent these pathogens from causing VAP in ICU patients.
format article
author Nishat Hussain Ahmed
Tabish Hussain
Indu Biswal
author_facet Nishat Hussain Ahmed
Tabish Hussain
Indu Biswal
author_sort Nishat Hussain Ahmed
title Antimicrobial resistance of bacterial isolates from respiratory secretions of ventilated patients in a multi-specialty hospital
title_short Antimicrobial resistance of bacterial isolates from respiratory secretions of ventilated patients in a multi-specialty hospital
title_full Antimicrobial resistance of bacterial isolates from respiratory secretions of ventilated patients in a multi-specialty hospital
title_fullStr Antimicrobial resistance of bacterial isolates from respiratory secretions of ventilated patients in a multi-specialty hospital
title_full_unstemmed Antimicrobial resistance of bacterial isolates from respiratory secretions of ventilated patients in a multi-specialty hospital
title_sort antimicrobial resistance of bacterial isolates from respiratory secretions of ventilated patients in a multi-specialty hospital
publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate 2015
url https://doaj.org/article/0a90912d5b4449bcb403adcbbc56bb12
work_keys_str_mv AT nishathussainahmed antimicrobialresistanceofbacterialisolatesfromrespiratorysecretionsofventilatedpatientsinamultispecialtyhospital
AT tabishhussain antimicrobialresistanceofbacterialisolatesfromrespiratorysecretionsofventilatedpatientsinamultispecialtyhospital
AT indubiswal antimicrobialresistanceofbacterialisolatesfromrespiratorysecretionsofventilatedpatientsinamultispecialtyhospital
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