Integration of intestinal microbiota and transcriptomic and metabolomic responses reveals the toxic responses of Litopenaeus vannamei to microcystin-LR

Microcystin-LR (MC-LR) is a hazardous hepatotoxin substance that threaten aquatic animals. Intestinal microbes can interact with and influence the health of their hosts. In this study, the shrimp Litopenaeus vannamei were exposed to 0.1 or 1 µg/L MC-LR for 72 h, and changes in intestinal microbial c...

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Autores principales:	Yafei Duan, Zijun Lu, Shimin Zeng, Xueming Dan, Zequan Mo, Jiasong Zhang, Yanwei Li
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Shrimp Microcystin-LR Intestinal microbial Transcriptome Metabolome Environmental pollution TD172-193.5 Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/0a936e4ae3fd4717bd7fb24973a60bb2
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spelling	oai:doaj.org-article:0a936e4ae3fd4717bd7fb24973a60bb22021-12-04T04:32:01ZIntegration of intestinal microbiota and transcriptomic and metabolomic responses reveals the toxic responses of Litopenaeus vannamei to microcystin-LR0147-651310.1016/j.ecoenv.2021.113030https://doaj.org/article/0a936e4ae3fd4717bd7fb24973a60bb22021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0147651321011428https://doaj.org/toc/0147-6513Microcystin-LR (MC-LR) is a hazardous hepatotoxin substance that threaten aquatic animals. Intestinal microbes can interact with and influence the health of their hosts. In this study, the shrimp Litopenaeus vannamei were exposed to 0.1 or 1 µg/L MC-LR for 72 h, and changes in intestinal microbial community and hepatopancreas transcriptome and metabolome were investigated. The results showed that both two doses of MC-LR increased intestinal microbial diversity and caused community composition variation by decreasing the abundances of putatively beneficial bacteria (Alloprevotella, Prevotella 1, Bacteroidales S24–7 group_norank and Lactobacillus). A large number of immune-related genes were differentially expressed in the hepatopancreas, including pattern recognition receptors and antimicrobial molecules; nutrient digestion and detoxification metabolism dysfunction were also induced. Furthermore, MC-LR altered hepatopancreas metabolic phenotypes, especially amino acid metabolism, the citric acid cycle, and linoleic acid and arachidonic acid metabolism. The changes in the intestinal bacteria were correlated with the immune factors and metabolic functions of their host. This study provides evidence for the toxicity of MC-LR on shrimp and identifies several biomarkers associated with the stress response.Yafei DuanZijun LuShimin ZengXueming DanZequan MoJiasong ZhangYanwei LiElsevierarticleShrimpMicrocystin-LRIntestinal microbialTranscriptomeMetabolomeEnvironmental pollutionTD172-193.5Environmental sciencesGE1-350ENEcotoxicology and Environmental Safety, Vol 228, Iss , Pp 113030- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Shrimp Microcystin-LR Intestinal microbial Transcriptome Metabolome Environmental pollution TD172-193.5 Environmental sciences GE1-350
spellingShingle	Shrimp Microcystin-LR Intestinal microbial Transcriptome Metabolome Environmental pollution TD172-193.5 Environmental sciences GE1-350 Yafei Duan Zijun Lu Shimin Zeng Xueming Dan Zequan Mo Jiasong Zhang Yanwei Li Integration of intestinal microbiota and transcriptomic and metabolomic responses reveals the toxic responses of Litopenaeus vannamei to microcystin-LR
description	Microcystin-LR (MC-LR) is a hazardous hepatotoxin substance that threaten aquatic animals. Intestinal microbes can interact with and influence the health of their hosts. In this study, the shrimp Litopenaeus vannamei were exposed to 0.1 or 1 µg/L MC-LR for 72 h, and changes in intestinal microbial community and hepatopancreas transcriptome and metabolome were investigated. The results showed that both two doses of MC-LR increased intestinal microbial diversity and caused community composition variation by decreasing the abundances of putatively beneficial bacteria (Alloprevotella, Prevotella 1, Bacteroidales S24–7 group_norank and Lactobacillus). A large number of immune-related genes were differentially expressed in the hepatopancreas, including pattern recognition receptors and antimicrobial molecules; nutrient digestion and detoxification metabolism dysfunction were also induced. Furthermore, MC-LR altered hepatopancreas metabolic phenotypes, especially amino acid metabolism, the citric acid cycle, and linoleic acid and arachidonic acid metabolism. The changes in the intestinal bacteria were correlated with the immune factors and metabolic functions of their host. This study provides evidence for the toxicity of MC-LR on shrimp and identifies several biomarkers associated with the stress response.
format	article
author	Yafei Duan Zijun Lu Shimin Zeng Xueming Dan Zequan Mo Jiasong Zhang Yanwei Li
author_facet	Yafei Duan Zijun Lu Shimin Zeng Xueming Dan Zequan Mo Jiasong Zhang Yanwei Li
author_sort	Yafei Duan
title	Integration of intestinal microbiota and transcriptomic and metabolomic responses reveals the toxic responses of Litopenaeus vannamei to microcystin-LR
title_short	Integration of intestinal microbiota and transcriptomic and metabolomic responses reveals the toxic responses of Litopenaeus vannamei to microcystin-LR
title_full	Integration of intestinal microbiota and transcriptomic and metabolomic responses reveals the toxic responses of Litopenaeus vannamei to microcystin-LR
title_fullStr	Integration of intestinal microbiota and transcriptomic and metabolomic responses reveals the toxic responses of Litopenaeus vannamei to microcystin-LR
title_full_unstemmed	Integration of intestinal microbiota and transcriptomic and metabolomic responses reveals the toxic responses of Litopenaeus vannamei to microcystin-LR
title_sort	integration of intestinal microbiota and transcriptomic and metabolomic responses reveals the toxic responses of litopenaeus vannamei to microcystin-lr
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/0a936e4ae3fd4717bd7fb24973a60bb2
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Integration of intestinal microbiota and transcriptomic and metabolomic responses reveals the toxic responses of Litopenaeus vannamei to microcystin-LR

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