Amyloid precursor protein is trafficked and secreted via synaptic vesicles.
A large body of evidence has implicated amyloid precursor protein (APP) and its proteolytic derivatives as key players in the physiological context of neuronal synaptogenesis and synapse maintenance, as well as in the pathology of Alzheimer's Disease (AD). Although APP processing and release ar...
Guardado en:
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2011
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/0a96d424466346ceb490fa796332a47d |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:0a96d424466346ceb490fa796332a47d |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:0a96d424466346ceb490fa796332a47d2021-11-18T06:55:06ZAmyloid precursor protein is trafficked and secreted via synaptic vesicles.1932-620310.1371/journal.pone.0018754https://doaj.org/article/0a96d424466346ceb490fa796332a47d2011-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21556148/?tool=EBIhttps://doaj.org/toc/1932-6203A large body of evidence has implicated amyloid precursor protein (APP) and its proteolytic derivatives as key players in the physiological context of neuronal synaptogenesis and synapse maintenance, as well as in the pathology of Alzheimer's Disease (AD). Although APP processing and release are known to occur in response to neuronal stimulation, the exact mechanism by which APP reaches the neuronal surface is unclear. We now demonstrate that a small but relevant number of synaptic vesicles contain APP, which can be released during neuronal activity, and most likely represent the major exocytic pathway of APP. This novel finding leads us to propose a revised model of presynaptic APP trafficking that reconciles existing knowledge on APP with our present understanding of vesicular release and recycling.Teja W GroemerCora S ThielMatthew HoltDietmar RiedelYunfeng HuaJana HüveBenjamin G WilhelmJürgen KlingaufPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 4, p e18754 (2011) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Teja W Groemer Cora S Thiel Matthew Holt Dietmar Riedel Yunfeng Hua Jana Hüve Benjamin G Wilhelm Jürgen Klingauf Amyloid precursor protein is trafficked and secreted via synaptic vesicles. |
| description |
A large body of evidence has implicated amyloid precursor protein (APP) and its proteolytic derivatives as key players in the physiological context of neuronal synaptogenesis and synapse maintenance, as well as in the pathology of Alzheimer's Disease (AD). Although APP processing and release are known to occur in response to neuronal stimulation, the exact mechanism by which APP reaches the neuronal surface is unclear. We now demonstrate that a small but relevant number of synaptic vesicles contain APP, which can be released during neuronal activity, and most likely represent the major exocytic pathway of APP. This novel finding leads us to propose a revised model of presynaptic APP trafficking that reconciles existing knowledge on APP with our present understanding of vesicular release and recycling. |
| format |
article |
| author |
Teja W Groemer Cora S Thiel Matthew Holt Dietmar Riedel Yunfeng Hua Jana Hüve Benjamin G Wilhelm Jürgen Klingauf |
| author_facet |
Teja W Groemer Cora S Thiel Matthew Holt Dietmar Riedel Yunfeng Hua Jana Hüve Benjamin G Wilhelm Jürgen Klingauf |
| author_sort |
Teja W Groemer |
| title |
Amyloid precursor protein is trafficked and secreted via synaptic vesicles. |
| title_short |
Amyloid precursor protein is trafficked and secreted via synaptic vesicles. |
| title_full |
Amyloid precursor protein is trafficked and secreted via synaptic vesicles. |
| title_fullStr |
Amyloid precursor protein is trafficked and secreted via synaptic vesicles. |
| title_full_unstemmed |
Amyloid precursor protein is trafficked and secreted via synaptic vesicles. |
| title_sort |
amyloid precursor protein is trafficked and secreted via synaptic vesicles. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/0a96d424466346ceb490fa796332a47d |
| work_keys_str_mv |
AT tejawgroemer amyloidprecursorproteinistraffickedandsecretedviasynapticvesicles AT corasthiel amyloidprecursorproteinistraffickedandsecretedviasynapticvesicles AT matthewholt amyloidprecursorproteinistraffickedandsecretedviasynapticvesicles AT dietmarriedel amyloidprecursorproteinistraffickedandsecretedviasynapticvesicles AT yunfenghua amyloidprecursorproteinistraffickedandsecretedviasynapticvesicles AT janahuve amyloidprecursorproteinistraffickedandsecretedviasynapticvesicles AT benjamingwilhelm amyloidprecursorproteinistraffickedandsecretedviasynapticvesicles AT jurgenklingauf amyloidprecursorproteinistraffickedandsecretedviasynapticvesicles |
| _version_ |
1718424210412404736 |