Successful Treatment of Ulcerative-Type Pyoderma Gangrenosum with a Combination Therapy of Oral Prednisolone, Vacuum-Assisted Closure, and Skin Grafting

Pyoderma gangrenosum (PG) is a relatively rare inflammatory skin disease that progressively causes necrotic ulceration mainly on the lower extremities and trunk. Systemic corticosteroid is considered a first-line treatment for PG as it facilitates wound healing; however, several cases where tumor ne...

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Autores principales:	Hiroyuki Goto, Yoshimoto Okada, Seimi Watanabe, Kanako Danno, Shinya Yamamoto, Ryohei Ishiura, Yuichi Nakayama, Kohei Mitsui, Ayaka Ueki, Yasuo Nakai, Mitsunaga Narushima, Keiichi Yamanaka
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	pyoderma gangrenosum corticosteroid vacuum-assisted closure skin grafting Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/0a97645d2d9d4b7c88b2ec2055f13568
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spelling	oai:doaj.org-article:0a97645d2d9d4b7c88b2ec2055f135682021-11-18T11:08:46ZSuccessful Treatment of Ulcerative-Type Pyoderma Gangrenosum with a Combination Therapy of Oral Prednisolone, Vacuum-Assisted Closure, and Skin Grafting1662-656710.1159/000519659https://doaj.org/article/0a97645d2d9d4b7c88b2ec2055f135682021-10-01T00:00:00Zhttps://www.karger.com/Article/FullText/519659https://doaj.org/toc/1662-6567Pyoderma gangrenosum (PG) is a relatively rare inflammatory skin disease that progressively causes necrotic ulceration mainly on the lower extremities and trunk. Systemic corticosteroid is considered a first-line treatment for PG as it facilitates wound healing; however, several cases where tumor necrosis factor-α inhibitors, adalimumab and infliximab, were administered showed good response. For intractable PG with a large ulcer or problematic epithelization, chemical or mechanical debridement of necrotic tissue in combination with skin grafting may be necessary to promote wound healing. Our report presents a case of intractable ulcerative PG requiring oral prednisolone and skin grafting. Although mechanical debridement was performed, granulation was poor; therefore, after the PG activity became quiescent, we utilized a vacuum-assisted closure (VAC) system to promote granulation and adaptation of the grafted skin. Although more cases are required for a definitive conclusion, the VAC system may be a choice for PG with large ulcers.Hiroyuki GotoYoshimoto OkadaSeimi WatanabeKanako DannoShinya YamamotoRyohei IshiuraYuichi NakayamaKohei MitsuiAyaka UekiYasuo NakaiMitsunaga NarushimaKeiichi YamanakaKarger Publishersarticlepyoderma gangrenosumcorticosteroidvacuum-assisted closureskin graftingDermatologyRL1-803ENCase Reports in Dermatology, Vol 13, Iss 3, Pp 497-501 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pyoderma gangrenosum corticosteroid vacuum-assisted closure skin grafting Dermatology RL1-803
spellingShingle	pyoderma gangrenosum corticosteroid vacuum-assisted closure skin grafting Dermatology RL1-803 Hiroyuki Goto Yoshimoto Okada Seimi Watanabe Kanako Danno Shinya Yamamoto Ryohei Ishiura Yuichi Nakayama Kohei Mitsui Ayaka Ueki Yasuo Nakai Mitsunaga Narushima Keiichi Yamanaka Successful Treatment of Ulcerative-Type Pyoderma Gangrenosum with a Combination Therapy of Oral Prednisolone, Vacuum-Assisted Closure, and Skin Grafting
description	Pyoderma gangrenosum (PG) is a relatively rare inflammatory skin disease that progressively causes necrotic ulceration mainly on the lower extremities and trunk. Systemic corticosteroid is considered a first-line treatment for PG as it facilitates wound healing; however, several cases where tumor necrosis factor-α inhibitors, adalimumab and infliximab, were administered showed good response. For intractable PG with a large ulcer or problematic epithelization, chemical or mechanical debridement of necrotic tissue in combination with skin grafting may be necessary to promote wound healing. Our report presents a case of intractable ulcerative PG requiring oral prednisolone and skin grafting. Although mechanical debridement was performed, granulation was poor; therefore, after the PG activity became quiescent, we utilized a vacuum-assisted closure (VAC) system to promote granulation and adaptation of the grafted skin. Although more cases are required for a definitive conclusion, the VAC system may be a choice for PG with large ulcers.
format	article
author	Hiroyuki Goto Yoshimoto Okada Seimi Watanabe Kanako Danno Shinya Yamamoto Ryohei Ishiura Yuichi Nakayama Kohei Mitsui Ayaka Ueki Yasuo Nakai Mitsunaga Narushima Keiichi Yamanaka
author_facet	Hiroyuki Goto Yoshimoto Okada Seimi Watanabe Kanako Danno Shinya Yamamoto Ryohei Ishiura Yuichi Nakayama Kohei Mitsui Ayaka Ueki Yasuo Nakai Mitsunaga Narushima Keiichi Yamanaka
author_sort	Hiroyuki Goto
title	Successful Treatment of Ulcerative-Type Pyoderma Gangrenosum with a Combination Therapy of Oral Prednisolone, Vacuum-Assisted Closure, and Skin Grafting
title_short	Successful Treatment of Ulcerative-Type Pyoderma Gangrenosum with a Combination Therapy of Oral Prednisolone, Vacuum-Assisted Closure, and Skin Grafting
title_full	Successful Treatment of Ulcerative-Type Pyoderma Gangrenosum with a Combination Therapy of Oral Prednisolone, Vacuum-Assisted Closure, and Skin Grafting
title_fullStr	Successful Treatment of Ulcerative-Type Pyoderma Gangrenosum with a Combination Therapy of Oral Prednisolone, Vacuum-Assisted Closure, and Skin Grafting
title_full_unstemmed	Successful Treatment of Ulcerative-Type Pyoderma Gangrenosum with a Combination Therapy of Oral Prednisolone, Vacuum-Assisted Closure, and Skin Grafting
title_sort	successful treatment of ulcerative-type pyoderma gangrenosum with a combination therapy of oral prednisolone, vacuum-assisted closure, and skin grafting
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/0a97645d2d9d4b7c88b2ec2055f13568
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Successful Treatment of Ulcerative-Type Pyoderma Gangrenosum with a Combination Therapy of Oral Prednisolone, Vacuum-Assisted Closure, and Skin Grafting

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