Mucosal Schwann cell hamartoma of the gallbladder

Mucosal Schwann cell hamartoma (MSCH) is a rare benign neurogenic tumor characterized by pure S100p positive spindle cell proliferation. Most cases occur in the distal colon. Involvement of the gall bladder is exceedingly rare. There have been no reports of recurrence or a syndromic association wit...

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Autores principales:	Farhan Ismael, Sidrah Khawar, Ameer Hamza Hamza
Formato:	article
Lenguaje:	EN
Publicado:	University of São Paulo 2021
Materias:	Schwann cells Hamartoma Neurofibroma Neuroma Gallbladder MSCH Medicine R Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/0a9f2ab472d549a89a530dd67ae3d62a
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spelling	oai:doaj.org-article:0a9f2ab472d549a89a530dd67ae3d62a2021-11-19T04:03:39ZMucosal Schwann cell hamartoma of the gallbladder2236-1960https://doaj.org/article/0a9f2ab472d549a89a530dd67ae3d62a2021-11-01T00:00:00Zhttps://www.revistas.usp.br/autopsy/article/view/192670https://doaj.org/toc/2236-1960 Mucosal Schwann cell hamartoma (MSCH) is a rare benign neurogenic tumor characterized by pure S100p positive spindle cell proliferation. Most cases occur in the distal colon. Involvement of the gall bladder is exceedingly rare. There have been no reports of recurrence or a syndromic association with MSCH. Herein, we describe a case of MSCH of the gallbladder in a 55-year-old female patient with prior history of gastrointestinal neurofibromas who presented with abdominal pain. MR imaging revealed choledocholithiasis, gallbladder thickening, and marked biliary and pancreatic ductal dilation. The patient subsequently underwent cholecystectomy with choledochoduodenostomy. Histologic evaluation of the gallbladder showed diffuse expansion of the mucosa with S100p positive cells with spindly nuclei and indistinct cytoplasmic borders and diagnosis of MSCH of the gallbladder was rendered. Farhan IsmaelSidrah KhawarAmeer Hamza HamzaUniversity of São PauloarticleSchwann cellsHamartomaNeurofibromaNeuromaGallbladderMSCHMedicineRInternal medicineRC31-1245ENAutopsy and Case Reports, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Schwann cells Hamartoma Neurofibroma Neuroma Gallbladder MSCH Medicine R Internal medicine RC31-1245
spellingShingle	Schwann cells Hamartoma Neurofibroma Neuroma Gallbladder MSCH Medicine R Internal medicine RC31-1245 Farhan Ismael Sidrah Khawar Ameer Hamza Hamza Mucosal Schwann cell hamartoma of the gallbladder
description	Mucosal Schwann cell hamartoma (MSCH) is a rare benign neurogenic tumor characterized by pure S100p positive spindle cell proliferation. Most cases occur in the distal colon. Involvement of the gall bladder is exceedingly rare. There have been no reports of recurrence or a syndromic association with MSCH. Herein, we describe a case of MSCH of the gallbladder in a 55-year-old female patient with prior history of gastrointestinal neurofibromas who presented with abdominal pain. MR imaging revealed choledocholithiasis, gallbladder thickening, and marked biliary and pancreatic ductal dilation. The patient subsequently underwent cholecystectomy with choledochoduodenostomy. Histologic evaluation of the gallbladder showed diffuse expansion of the mucosa with S100p positive cells with spindly nuclei and indistinct cytoplasmic borders and diagnosis of MSCH of the gallbladder was rendered.
format	article
author	Farhan Ismael Sidrah Khawar Ameer Hamza Hamza
author_facet	Farhan Ismael Sidrah Khawar Ameer Hamza Hamza
author_sort	Farhan Ismael
title	Mucosal Schwann cell hamartoma of the gallbladder
title_short	Mucosal Schwann cell hamartoma of the gallbladder
title_full	Mucosal Schwann cell hamartoma of the gallbladder
title_fullStr	Mucosal Schwann cell hamartoma of the gallbladder
title_full_unstemmed	Mucosal Schwann cell hamartoma of the gallbladder
title_sort	mucosal schwann cell hamartoma of the gallbladder
publisher	University of São Paulo
publishDate	2021
url	https://doaj.org/article/0a9f2ab472d549a89a530dd67ae3d62a
work_keys_str_mv	AT farhanismael mucosalschwanncellhamartomaofthegallbladder AT sidrahkhawar mucosalschwanncellhamartomaofthegallbladder AT ameerhamzahamza mucosalschwanncellhamartomaofthegallbladder
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Mucosal Schwann cell hamartoma of the gallbladder

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