Recent Progress in Development of Polo-Like Kinase 1 Inhibitors: Efforts So Far

Polo-like kinase 1(Plk1) plays an important role in the inhibition of cell proliferation and which is come under the family of serine/threonine-protein kinase. Which is a highly specific target for cancer therapy. In some clinical studies, Plk1 has been identified as a target for cancer. Currently,...

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Autores principales:	Ramesh L. Sawant, Jyoti B. Wadekar, Rushikesh D. Ukirde, Ganesh D. Barkade
Formato:	article
Lenguaje:	EN
Publicado:	Tabriz University of Medical Sciences 2021
Materias:	kinase domain polo-like kinase 1 plk1 polo box domain patents small molecule inhibitors Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/0a9f7fde490847278b7fe11ff030ad94
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spelling	oai:doaj.org-article:0a9f7fde490847278b7fe11ff030ad942021-11-29T05:40:47ZRecent Progress in Development of Polo-Like Kinase 1 Inhibitors: Efforts So Far2383-288610.34172/PS.2021.19https://doaj.org/article/0a9f7fde490847278b7fe11ff030ad942021-12-01T00:00:00Zhttps://ps.tbzmed.ac.ir/PDF/ps-27-453.pdfhttps://doaj.org/toc/2383-2886Polo-like kinase 1(Plk1) plays an important role in the inhibition of cell proliferation and which is come under the family of serine/threonine-protein kinase. Which is a highly specific target for cancer therapy. In some clinical studies, Plk1 has been identified as a target for cancer. Currently, so many scientists are working on the development of the Plk1 inhibitors and so many scientists and researchers thinking about working on it. Recent strategy for Plk1 inhibition is the development of small molecule inhibitors which will inhibit the Plk1 through the ATP-binding site of the Plk. Now new generation Plk1 inhibitors being tested clinically which are targeting polo box domain. This review highlights the recent progress made in the development of Plk1 inhibitors as anticancer agents.Ramesh L. SawantJyoti B. WadekarRushikesh D. UkirdeGanesh D. BarkadeTabriz University of Medical Sciencesarticlekinase domainpolo-like kinase 1plk1polo box domainpatentssmall molecule inhibitorsPharmacy and materia medicaRS1-441ENPharmaceutical Sciences, Vol 27, Iss 4, Pp 453-471 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	kinase domain polo-like kinase 1 plk1 polo box domain patents small molecule inhibitors Pharmacy and materia medica RS1-441
spellingShingle	kinase domain polo-like kinase 1 plk1 polo box domain patents small molecule inhibitors Pharmacy and materia medica RS1-441 Ramesh L. Sawant Jyoti B. Wadekar Rushikesh D. Ukirde Ganesh D. Barkade Recent Progress in Development of Polo-Like Kinase 1 Inhibitors: Efforts So Far
description	Polo-like kinase 1(Plk1) plays an important role in the inhibition of cell proliferation and which is come under the family of serine/threonine-protein kinase. Which is a highly specific target for cancer therapy. In some clinical studies, Plk1 has been identified as a target for cancer. Currently, so many scientists are working on the development of the Plk1 inhibitors and so many scientists and researchers thinking about working on it. Recent strategy for Plk1 inhibition is the development of small molecule inhibitors which will inhibit the Plk1 through the ATP-binding site of the Plk. Now new generation Plk1 inhibitors being tested clinically which are targeting polo box domain. This review highlights the recent progress made in the development of Plk1 inhibitors as anticancer agents.
format	article
author	Ramesh L. Sawant Jyoti B. Wadekar Rushikesh D. Ukirde Ganesh D. Barkade
author_facet	Ramesh L. Sawant Jyoti B. Wadekar Rushikesh D. Ukirde Ganesh D. Barkade
author_sort	Ramesh L. Sawant
title	Recent Progress in Development of Polo-Like Kinase 1 Inhibitors: Efforts So Far
title_short	Recent Progress in Development of Polo-Like Kinase 1 Inhibitors: Efforts So Far
title_full	Recent Progress in Development of Polo-Like Kinase 1 Inhibitors: Efforts So Far
title_fullStr	Recent Progress in Development of Polo-Like Kinase 1 Inhibitors: Efforts So Far
title_full_unstemmed	Recent Progress in Development of Polo-Like Kinase 1 Inhibitors: Efforts So Far
title_sort	recent progress in development of polo-like kinase 1 inhibitors: efforts so far
publisher	Tabriz University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/0a9f7fde490847278b7fe11ff030ad94
work_keys_str_mv	AT rameshlsawant recentprogressindevelopmentofpololikekinase1inhibitorseffortssofar AT jyotibwadekar recentprogressindevelopmentofpololikekinase1inhibitorseffortssofar AT rushikeshdukirde recentprogressindevelopmentofpololikekinase1inhibitorseffortssofar AT ganeshdbarkade recentprogressindevelopmentofpololikekinase1inhibitorseffortssofar
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Recent Progress in Development of Polo-Like Kinase 1 Inhibitors: Efforts So Far

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