Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site

Prior to anaphase, securin binds separase and thereby prevents cohesin cleavage. Here, the authors develop a method to produce active securin-free separase, identify a docking motif in cohesin that promotes cleavage, and show that securin interferes with this interaction.

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Autores principales:	Laura E. Rosen, Joseph E. Klebba, Jonathan B. Asfaha, Chloe M. Ghent, Melody G. Campbell, Yifan Cheng, David O. Morgan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0aa2e46a831d4778b0b71ae518c06875
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spelling	oai:doaj.org-article:0aa2e46a831d4778b0b71ae518c068752021-12-02T16:58:24ZCohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site10.1038/s41467-019-13209-y2041-1723https://doaj.org/article/0aa2e46a831d4778b0b71ae518c068752019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13209-yhttps://doaj.org/toc/2041-1723Prior to anaphase, securin binds separase and thereby prevents cohesin cleavage. Here, the authors develop a method to produce active securin-free separase, identify a docking motif in cohesin that promotes cleavage, and show that securin interferes with this interaction.Laura E. RosenJoseph E. KlebbaJonathan B. AsfahaChloe M. GhentMelody G. CampbellYifan ChengDavid O. MorganNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laura E. Rosen Joseph E. Klebba Jonathan B. Asfaha Chloe M. Ghent Melody G. Campbell Yifan Cheng David O. Morgan Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site
description	Prior to anaphase, securin binds separase and thereby prevents cohesin cleavage. Here, the authors develop a method to produce active securin-free separase, identify a docking motif in cohesin that promotes cleavage, and show that securin interferes with this interaction.
format	article
author	Laura E. Rosen Joseph E. Klebba Jonathan B. Asfaha Chloe M. Ghent Melody G. Campbell Yifan Cheng David O. Morgan
author_facet	Laura E. Rosen Joseph E. Klebba Jonathan B. Asfaha Chloe M. Ghent Melody G. Campbell Yifan Cheng David O. Morgan
author_sort	Laura E. Rosen
title	Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site
title_short	Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site
title_full	Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site
title_fullStr	Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site
title_full_unstemmed	Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site
title_sort	cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0aa2e46a831d4778b0b71ae518c06875
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Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site

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