Remnant renal volume can predict prognosis of remnant renal function in kidney transplantation donors: a prospective observational study

Abstract Background Safety and survival during and after donor nephrectomy (DN) are one of the main concerns in living kidney donors (LKDs). Therefore, kidney (left/right) to be procured should be determined after considering the difficulty of DN, as well as the preservation of remnant renal functio...

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Autores principales:	Shunta Hori, Nobumichi Tanaka, Tatsuo Yoneda, Nobutaka Nishimura, Mitsuru Tomizawa, Tomonori Nakahama, Yasushi Nakai, Makito Miyake, Kazumasa Torimoto, Kiyoyuki Minamiguchi, Kiyohide Fujimoto
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Computed tomography volumetry Donor selection Living donation Living donor kidney transplantation Remnant renal function Remnant renal volume Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/0aa3a5bea2e34c3bb442fbdb8bc4dca9
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spelling	oai:doaj.org-article:0aa3a5bea2e34c3bb442fbdb8bc4dca92021-11-08T11:17:56ZRemnant renal volume can predict prognosis of remnant renal function in kidney transplantation donors: a prospective observational study10.1186/s12882-021-02568-81471-2369https://doaj.org/article/0aa3a5bea2e34c3bb442fbdb8bc4dca92021-11-01T00:00:00Zhttps://doi.org/10.1186/s12882-021-02568-8https://doaj.org/toc/1471-2369Abstract Background Safety and survival during and after donor nephrectomy (DN) are one of the main concerns in living kidney donors (LKDs). Therefore, kidney (left/right) to be procured should be determined after considering the difficulty of DN, as well as the preservation of remnant renal function (RRF). In this prospective study, we investigated the roles of computed tomography volumetry (CTV) in split renal function (SRF) and established a predictive model for RRF in LKDs. Methods We assessed 103 LKDs who underwent DN at our institute. The Volume Analyzer SYNAPSE VINCENT image analysis system were used as CTV. RRF was defined as the estimated glomerular filtration rate (eGFR) 12 months after DN. The association between various factors measured by CTV and RRF were investigated, and a role of CTV on prediction for RRF was assessed. Results The median age and the preoperative eGFR were 58 years and 80.7 mL/min/1.73m2, respectively. Each factor measured by CTV showed an association with RRF. The ratio of remnant renal volume to body surface area (RRV/BSA) could predict RRF. In addition, RRV/BSA could predict RRF more accurately when used together with age and 24-h creatinine clearance (CrCl). Conclusions Our findings suggest that RRV/BSA measured by CTV can play an important role in predicting RRF, and a comprehensive assessment including age and CrCl is important to determine the kidney to be procured.Shunta HoriNobumichi TanakaTatsuo YonedaNobutaka NishimuraMitsuru TomizawaTomonori NakahamaYasushi NakaiMakito MiyakeKazumasa TorimotoKiyoyuki MinamiguchiKiyohide FujimotoBMCarticleComputed tomography volumetryDonor selectionLiving donationLiving donor kidney transplantationRemnant renal functionRemnant renal volumeDiseases of the genitourinary system. UrologyRC870-923ENBMC Nephrology, Vol 22, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Computed tomography volumetry Donor selection Living donation Living donor kidney transplantation Remnant renal function Remnant renal volume Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Computed tomography volumetry Donor selection Living donation Living donor kidney transplantation Remnant renal function Remnant renal volume Diseases of the genitourinary system. Urology RC870-923 Shunta Hori Nobumichi Tanaka Tatsuo Yoneda Nobutaka Nishimura Mitsuru Tomizawa Tomonori Nakahama Yasushi Nakai Makito Miyake Kazumasa Torimoto Kiyoyuki Minamiguchi Kiyohide Fujimoto Remnant renal volume can predict prognosis of remnant renal function in kidney transplantation donors: a prospective observational study
description	Abstract Background Safety and survival during and after donor nephrectomy (DN) are one of the main concerns in living kidney donors (LKDs). Therefore, kidney (left/right) to be procured should be determined after considering the difficulty of DN, as well as the preservation of remnant renal function (RRF). In this prospective study, we investigated the roles of computed tomography volumetry (CTV) in split renal function (SRF) and established a predictive model for RRF in LKDs. Methods We assessed 103 LKDs who underwent DN at our institute. The Volume Analyzer SYNAPSE VINCENT image analysis system were used as CTV. RRF was defined as the estimated glomerular filtration rate (eGFR) 12 months after DN. The association between various factors measured by CTV and RRF were investigated, and a role of CTV on prediction for RRF was assessed. Results The median age and the preoperative eGFR were 58 years and 80.7 mL/min/1.73m2, respectively. Each factor measured by CTV showed an association with RRF. The ratio of remnant renal volume to body surface area (RRV/BSA) could predict RRF. In addition, RRV/BSA could predict RRF more accurately when used together with age and 24-h creatinine clearance (CrCl). Conclusions Our findings suggest that RRV/BSA measured by CTV can play an important role in predicting RRF, and a comprehensive assessment including age and CrCl is important to determine the kidney to be procured.
format	article
author	Shunta Hori Nobumichi Tanaka Tatsuo Yoneda Nobutaka Nishimura Mitsuru Tomizawa Tomonori Nakahama Yasushi Nakai Makito Miyake Kazumasa Torimoto Kiyoyuki Minamiguchi Kiyohide Fujimoto
author_facet	Shunta Hori Nobumichi Tanaka Tatsuo Yoneda Nobutaka Nishimura Mitsuru Tomizawa Tomonori Nakahama Yasushi Nakai Makito Miyake Kazumasa Torimoto Kiyoyuki Minamiguchi Kiyohide Fujimoto
author_sort	Shunta Hori
title	Remnant renal volume can predict prognosis of remnant renal function in kidney transplantation donors: a prospective observational study
title_short	Remnant renal volume can predict prognosis of remnant renal function in kidney transplantation donors: a prospective observational study
title_full	Remnant renal volume can predict prognosis of remnant renal function in kidney transplantation donors: a prospective observational study
title_fullStr	Remnant renal volume can predict prognosis of remnant renal function in kidney transplantation donors: a prospective observational study
title_full_unstemmed	Remnant renal volume can predict prognosis of remnant renal function in kidney transplantation donors: a prospective observational study
title_sort	remnant renal volume can predict prognosis of remnant renal function in kidney transplantation donors: a prospective observational study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/0aa3a5bea2e34c3bb442fbdb8bc4dca9
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Remnant renal volume can predict prognosis of remnant renal function in kidney transplantation donors: a prospective observational study

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