STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment
Antimitotic compounds, such as paclitaxel, induce cell death in cycling cancer cells only. Here, the authors show that paclitaxel-targeted breast cancer cells prime neighboring cells to apoptosis through a STING-mediated paracrine signaling pathway.
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Nature Portfolio
2020
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oai:doaj.org-article:0aa8ad60806d444b913612a87eb4037b2021-12-02T17:31:40ZSTING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment10.1038/s41467-019-13689-y2041-1723https://doaj.org/article/0aa8ad60806d444b913612a87eb4037b2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13689-yhttps://doaj.org/toc/2041-1723Antimitotic compounds, such as paclitaxel, induce cell death in cycling cancer cells only. Here, the authors show that paclitaxel-targeted breast cancer cells prime neighboring cells to apoptosis through a STING-mediated paracrine signaling pathway.Steven LohardNathalie BourgeoisLaurent MailletFabien GautierAurélie FétiveauHamza LaslaFrédérique NguyenCéline VuillierAlison DumontAgnès Moreau-AubryMorgane FrapinLaurent DavidDelphine LoussouarnOlivier KerdraonMario CamponePascal JézéquelPhilippe P. JuinSophie Barillé-NionNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Steven Lohard Nathalie Bourgeois Laurent Maillet Fabien Gautier Aurélie Fétiveau Hamza Lasla Frédérique Nguyen Céline Vuillier Alison Dumont Agnès Moreau-Aubry Morgane Frapin Laurent David Delphine Loussouarn Olivier Kerdraon Mario Campone Pascal Jézéquel Philippe P. Juin Sophie Barillé-Nion STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment |
| description |
Antimitotic compounds, such as paclitaxel, induce cell death in cycling cancer cells only. Here, the authors show that paclitaxel-targeted breast cancer cells prime neighboring cells to apoptosis through a STING-mediated paracrine signaling pathway. |
| format |
article |
| author |
Steven Lohard Nathalie Bourgeois Laurent Maillet Fabien Gautier Aurélie Fétiveau Hamza Lasla Frédérique Nguyen Céline Vuillier Alison Dumont Agnès Moreau-Aubry Morgane Frapin Laurent David Delphine Loussouarn Olivier Kerdraon Mario Campone Pascal Jézéquel Philippe P. Juin Sophie Barillé-Nion |
| author_facet |
Steven Lohard Nathalie Bourgeois Laurent Maillet Fabien Gautier Aurélie Fétiveau Hamza Lasla Frédérique Nguyen Céline Vuillier Alison Dumont Agnès Moreau-Aubry Morgane Frapin Laurent David Delphine Loussouarn Olivier Kerdraon Mario Campone Pascal Jézéquel Philippe P. Juin Sophie Barillé-Nion |
| author_sort |
Steven Lohard |
| title |
STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment |
| title_short |
STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment |
| title_full |
STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment |
| title_fullStr |
STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment |
| title_full_unstemmed |
STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment |
| title_sort |
sting-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/0aa8ad60806d444b913612a87eb4037b |
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