STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment

STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment

Antimitotic compounds, such as paclitaxel, induce cell death in cycling cancer cells only. Here, the authors show that paclitaxel-targeted breast cancer cells prime neighboring cells to apoptosis through a STING-mediated paracrine signaling pathway.

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Autores principales: Steven Lohard, Nathalie Bourgeois, Laurent Maillet, Fabien Gautier, Aurélie Fétiveau, Hamza Lasla, Frédérique Nguyen, Céline Vuillier, Alison Dumont, Agnès Moreau-Aubry, Morgane Frapin, Laurent David, Delphine Loussouarn, Olivier Kerdraon, Mario Campone, Pascal Jézéquel, Philippe P. Juin, Sophie Barillé-Nion
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/0aa8ad60806d444b913612a87eb4037b
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