Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition

The endothelial to haematopoietic transition (EHT) is the process where haemogenic endothelium differentiates into haematopoietic stem and progenitor cells (HSPCs). Here the authors use single cell transcriptomics and antibody screening to identify CD44 as a marker of EHT that is required for EHT an...

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Autores principales:	Morgan Oatley, Özge Vargel Bölükbası, Valentine Svensson, Maya Shvartsman, Kerstin Ganter, Katharina Zirngibl, Polina V. Pavlovich, Vladislava Milchevskaya, Vladimira Foteva, Kedar N. Natarajan, Bianka Baying, Vladimir Benes, Kiran R. Patil, Sarah A. Teichmann, Christophe Lancrin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0aa92ddc62534df882beffaca6542b59
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spelling	oai:doaj.org-article:0aa92ddc62534df882beffaca6542b592021-12-02T14:40:51ZSingle-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition10.1038/s41467-019-14171-52041-1723https://doaj.org/article/0aa92ddc62534df882beffaca6542b592020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14171-5https://doaj.org/toc/2041-1723The endothelial to haematopoietic transition (EHT) is the process where haemogenic endothelium differentiates into haematopoietic stem and progenitor cells (HSPCs). Here the authors use single cell transcriptomics and antibody screening to identify CD44 as a marker of EHT that is required for EHT and HSPC development.Morgan OatleyÖzge Vargel BölükbasıValentine SvenssonMaya ShvartsmanKerstin GanterKatharina ZirngiblPolina V. PavlovichVladislava MilchevskayaVladimira FotevaKedar N. NatarajanBianka BayingVladimir BenesKiran R. PatilSarah A. TeichmannChristophe LancrinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Morgan Oatley Özge Vargel Bölükbası Valentine Svensson Maya Shvartsman Kerstin Ganter Katharina Zirngibl Polina V. Pavlovich Vladislava Milchevskaya Vladimira Foteva Kedar N. Natarajan Bianka Baying Vladimir Benes Kiran R. Patil Sarah A. Teichmann Christophe Lancrin Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition
description	The endothelial to haematopoietic transition (EHT) is the process where haemogenic endothelium differentiates into haematopoietic stem and progenitor cells (HSPCs). Here the authors use single cell transcriptomics and antibody screening to identify CD44 as a marker of EHT that is required for EHT and HSPC development.
format	article
author	Morgan Oatley Özge Vargel Bölükbası Valentine Svensson Maya Shvartsman Kerstin Ganter Katharina Zirngibl Polina V. Pavlovich Vladislava Milchevskaya Vladimira Foteva Kedar N. Natarajan Bianka Baying Vladimir Benes Kiran R. Patil Sarah A. Teichmann Christophe Lancrin
author_facet	Morgan Oatley Özge Vargel Bölükbası Valentine Svensson Maya Shvartsman Kerstin Ganter Katharina Zirngibl Polina V. Pavlovich Vladislava Milchevskaya Vladimira Foteva Kedar N. Natarajan Bianka Baying Vladimir Benes Kiran R. Patil Sarah A. Teichmann Christophe Lancrin
author_sort	Morgan Oatley
title	Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition
title_short	Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition
title_full	Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition
title_fullStr	Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition
title_full_unstemmed	Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition
title_sort	single-cell transcriptomics identifies cd44 as a marker and regulator of endothelial to haematopoietic transition
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0aa92ddc62534df882beffaca6542b59
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Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition

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