In situ click chemistry generation of cyclooxygenase-2 inhibitors

Traditional inflammation and pain relief drugs target both cyclooxygenase 1 and 2 (COX-1 and COX-2), causing severe side effects. Here, the authors use in situ click chemistry to develop COX-2 specific inhibitors with high in vivo anti-inflammatory activity.

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Autores principales:	Atul Bhardwaj, Jatinder Kaur, Melinda Wuest, Frank Wuest
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0aaf6cbf6f6f49aab5b878a4d847aa9e
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spelling	oai:doaj.org-article:0aaf6cbf6f6f49aab5b878a4d847aa9e2021-12-02T13:57:33ZIn situ click chemistry generation of cyclooxygenase-2 inhibitors10.1038/s41467-016-0009-62041-1723https://doaj.org/article/0aaf6cbf6f6f49aab5b878a4d847aa9e2017-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-016-0009-6https://doaj.org/toc/2041-1723Traditional inflammation and pain relief drugs target both cyclooxygenase 1 and 2 (COX-1 and COX-2), causing severe side effects. Here, the authors use in situ click chemistry to develop COX-2 specific inhibitors with high in vivo anti-inflammatory activity.Atul BhardwajJatinder KaurMelinda WuestFrank WuestNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Atul Bhardwaj Jatinder Kaur Melinda Wuest Frank Wuest In situ click chemistry generation of cyclooxygenase-2 inhibitors
description	Traditional inflammation and pain relief drugs target both cyclooxygenase 1 and 2 (COX-1 and COX-2), causing severe side effects. Here, the authors use in situ click chemistry to develop COX-2 specific inhibitors with high in vivo anti-inflammatory activity.
format	article
author	Atul Bhardwaj Jatinder Kaur Melinda Wuest Frank Wuest
author_facet	Atul Bhardwaj Jatinder Kaur Melinda Wuest Frank Wuest
author_sort	Atul Bhardwaj
title	In situ click chemistry generation of cyclooxygenase-2 inhibitors
title_short	In situ click chemistry generation of cyclooxygenase-2 inhibitors
title_full	In situ click chemistry generation of cyclooxygenase-2 inhibitors
title_fullStr	In situ click chemistry generation of cyclooxygenase-2 inhibitors
title_full_unstemmed	In situ click chemistry generation of cyclooxygenase-2 inhibitors
title_sort	in situ click chemistry generation of cyclooxygenase-2 inhibitors
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0aaf6cbf6f6f49aab5b878a4d847aa9e
work_keys_str_mv	AT atulbhardwaj insituclickchemistrygenerationofcyclooxygenase2inhibitors AT jatinderkaur insituclickchemistrygenerationofcyclooxygenase2inhibitors AT melindawuest insituclickchemistrygenerationofcyclooxygenase2inhibitors AT frankwuest insituclickchemistrygenerationofcyclooxygenase2inhibitors
_version_	1718392302030815232

In situ click chemistry generation of cyclooxygenase-2 inhibitors

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