Stochastic amplification of fluctuations in cortical up-states.

Cortical neurons are bistable; as a consequence their local field potentials can fluctuate between quiescent and active states, generating slow 0.5 2 Hz oscillations which are widely known as transitions between Up and Down States. Despite a large number of studies on Up-Down transitions, decipherin...

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Autores principales:	Jorge Hidalgo, Luís F Seoane, Jesús M Cortés, Miguel A Muñoz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0ab0aa3651c8439f9e10f92c35326650
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spelling	oai:doaj.org-article:0ab0aa3651c8439f9e10f92c353266502021-11-18T07:09:29ZStochastic amplification of fluctuations in cortical up-states.1932-620310.1371/journal.pone.0040710https://doaj.org/article/0ab0aa3651c8439f9e10f92c353266502012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22879879/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Cortical neurons are bistable; as a consequence their local field potentials can fluctuate between quiescent and active states, generating slow 0.5 2 Hz oscillations which are widely known as transitions between Up and Down States. Despite a large number of studies on Up-Down transitions, deciphering its nature, mechanisms and function are still today challenging tasks. In this paper we focus on recent experimental evidence, showing that a class of spontaneous oscillations can emerge within the Up states. In particular, a non-trivial peak around 20 Hz appears in their associated power-spectra, what produces an enhancement of the activity power for higher frequencies (in the 30-90 Hz band). Moreover, this rhythm within Ups seems to be an emergent or collective phenomenon given that individual neurons do not lock to it as they remain mostly unsynchronized. Remarkably, similar oscillations (and the concomitant peak in the spectrum) do not appear in the Down states. Here we shed light on these findings by using different computational models for the dynamics of cortical networks in presence of different levels of physiological complexity. Our conclusion, supported by both theory and simulations, is that the collective phenomenon of "stochastic amplification of fluctuations"--previously described in other contexts such as Ecology and Epidemiology--explains in an elegant and parsimonious manner, beyond model-dependent details, this extra-rhythm emerging only in the Up states but not in the Downs.Jorge HidalgoLuís F SeoaneJesús M CortésMiguel A MuñozPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e40710 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jorge Hidalgo Luís F Seoane Jesús M Cortés Miguel A Muñoz Stochastic amplification of fluctuations in cortical up-states.
description	Cortical neurons are bistable; as a consequence their local field potentials can fluctuate between quiescent and active states, generating slow 0.5 2 Hz oscillations which are widely known as transitions between Up and Down States. Despite a large number of studies on Up-Down transitions, deciphering its nature, mechanisms and function are still today challenging tasks. In this paper we focus on recent experimental evidence, showing that a class of spontaneous oscillations can emerge within the Up states. In particular, a non-trivial peak around 20 Hz appears in their associated power-spectra, what produces an enhancement of the activity power for higher frequencies (in the 30-90 Hz band). Moreover, this rhythm within Ups seems to be an emergent or collective phenomenon given that individual neurons do not lock to it as they remain mostly unsynchronized. Remarkably, similar oscillations (and the concomitant peak in the spectrum) do not appear in the Down states. Here we shed light on these findings by using different computational models for the dynamics of cortical networks in presence of different levels of physiological complexity. Our conclusion, supported by both theory and simulations, is that the collective phenomenon of "stochastic amplification of fluctuations"--previously described in other contexts such as Ecology and Epidemiology--explains in an elegant and parsimonious manner, beyond model-dependent details, this extra-rhythm emerging only in the Up states but not in the Downs.
format	article
author	Jorge Hidalgo Luís F Seoane Jesús M Cortés Miguel A Muñoz
author_facet	Jorge Hidalgo Luís F Seoane Jesús M Cortés Miguel A Muñoz
author_sort	Jorge Hidalgo
title	Stochastic amplification of fluctuations in cortical up-states.
title_short	Stochastic amplification of fluctuations in cortical up-states.
title_full	Stochastic amplification of fluctuations in cortical up-states.
title_fullStr	Stochastic amplification of fluctuations in cortical up-states.
title_full_unstemmed	Stochastic amplification of fluctuations in cortical up-states.
title_sort	stochastic amplification of fluctuations in cortical up-states.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/0ab0aa3651c8439f9e10f92c35326650
work_keys_str_mv	AT jorgehidalgo stochasticamplificationoffluctuationsincorticalupstates AT luisfseoane stochasticamplificationoffluctuationsincorticalupstates AT jesusmcortes stochasticamplificationoffluctuationsincorticalupstates AT miguelamunoz stochasticamplificationoffluctuationsincorticalupstates
_version_	1718423834611154944

Stochastic amplification of fluctuations in cortical up-states.

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