Prognostic Impact of Sleep Patterns and Related-Drugs in Patients with Heart Failure

Sleep disturbances are frequent among patients with heart failure (HF). We hypothesized that self-reported sleep disturbances are associated with a poor prognosis in patients with HF. A longitudinal study of 119 patients with HF was carried out to assess the association between sleep disturbances an...

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Autores principales:	François Bughin, Isabelle Jaussent, Bronia Ayoub, Sylvain Aguilhon, Nicolas Chapet, Sonia Soltani, Jacques Mercier, Yves Dauvilliers, François Roubille
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	heart failure sleep disturbances sleep patterns central nervous system drugs sleep quality Medicine R
Acceso en línea:	https://doaj.org/article/0ab7661bb33b4f7fa3b64930cd918632
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spelling	oai:doaj.org-article:0ab7661bb33b4f7fa3b64930cd9186322021-11-25T18:02:19ZPrognostic Impact of Sleep Patterns and Related-Drugs in Patients with Heart Failure10.3390/jcm102253872077-0383https://doaj.org/article/0ab7661bb33b4f7fa3b64930cd9186322021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5387https://doaj.org/toc/2077-0383Sleep disturbances are frequent among patients with heart failure (HF). We hypothesized that self-reported sleep disturbances are associated with a poor prognosis in patients with HF. A longitudinal study of 119 patients with HF was carried out to assess the association between sleep disturbances and the occurrence of major cardiovascular events (MACE). All patients with HF completed self-administered questionnaires on sleepiness, fatigue, insomnia, quality of sleep, sleep patterns, anxiety and depressive symptoms, and central nervous system (CNS) drugs intake. Patients were followed for a median of 888 days. Cox models were used to estimate the risk of MACE associated with baseline sleep characteristics. After adjustment for age, the risk of a future MACE increased with CNS drugs intake, sleep quality and insomnia scores as well with increased sleep latency, decreased sleep efficiency and total sleep time. However, after adjustment for left ventricular ejection fraction and hypercholesterolemia the HR failed to be significant except for CNS drugs and total sleep time. CNS drugs intake and decreased total sleep time were independently associated with an increased risk of MACE in patients with HF. Routine assessment of self-reported sleep disturbances should be considered to prevent the natural progression of HF.François BughinIsabelle JaussentBronia AyoubSylvain AguilhonNicolas ChapetSonia SoltaniJacques MercierYves DauvilliersFrançois RoubilleMDPI AGarticleheart failuresleep disturbancessleep patternscentral nervous system drugssleep qualityMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5387, p 5387 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	heart failure sleep disturbances sleep patterns central nervous system drugs sleep quality Medicine R
spellingShingle	heart failure sleep disturbances sleep patterns central nervous system drugs sleep quality Medicine R François Bughin Isabelle Jaussent Bronia Ayoub Sylvain Aguilhon Nicolas Chapet Sonia Soltani Jacques Mercier Yves Dauvilliers François Roubille Prognostic Impact of Sleep Patterns and Related-Drugs in Patients with Heart Failure
description	Sleep disturbances are frequent among patients with heart failure (HF). We hypothesized that self-reported sleep disturbances are associated with a poor prognosis in patients with HF. A longitudinal study of 119 patients with HF was carried out to assess the association between sleep disturbances and the occurrence of major cardiovascular events (MACE). All patients with HF completed self-administered questionnaires on sleepiness, fatigue, insomnia, quality of sleep, sleep patterns, anxiety and depressive symptoms, and central nervous system (CNS) drugs intake. Patients were followed for a median of 888 days. Cox models were used to estimate the risk of MACE associated with baseline sleep characteristics. After adjustment for age, the risk of a future MACE increased with CNS drugs intake, sleep quality and insomnia scores as well with increased sleep latency, decreased sleep efficiency and total sleep time. However, after adjustment for left ventricular ejection fraction and hypercholesterolemia the HR failed to be significant except for CNS drugs and total sleep time. CNS drugs intake and decreased total sleep time were independently associated with an increased risk of MACE in patients with HF. Routine assessment of self-reported sleep disturbances should be considered to prevent the natural progression of HF.
format	article
author	François Bughin Isabelle Jaussent Bronia Ayoub Sylvain Aguilhon Nicolas Chapet Sonia Soltani Jacques Mercier Yves Dauvilliers François Roubille
author_facet	François Bughin Isabelle Jaussent Bronia Ayoub Sylvain Aguilhon Nicolas Chapet Sonia Soltani Jacques Mercier Yves Dauvilliers François Roubille
author_sort	François Bughin
title	Prognostic Impact of Sleep Patterns and Related-Drugs in Patients with Heart Failure
title_short	Prognostic Impact of Sleep Patterns and Related-Drugs in Patients with Heart Failure
title_full	Prognostic Impact of Sleep Patterns and Related-Drugs in Patients with Heart Failure
title_fullStr	Prognostic Impact of Sleep Patterns and Related-Drugs in Patients with Heart Failure
title_full_unstemmed	Prognostic Impact of Sleep Patterns and Related-Drugs in Patients with Heart Failure
title_sort	prognostic impact of sleep patterns and related-drugs in patients with heart failure
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0ab7661bb33b4f7fa3b64930cd918632
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Prognostic Impact of Sleep Patterns and Related-Drugs in Patients with Heart Failure

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