Administration of BMSCs with muscone in rats with gentamicin-induced AKI improves their therapeutic efficacy.

The therapeutic action of bone marrow-derived mesenchymal stem cells (BMSCs) in acute kidney injury (AKI) has been reported by several groups. However, recent studies indicated that BMSCs homed to kidney tissues at very low levels after transplantation. The lack of specific homing of exogenously inf...

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Autores principales:	Pengfei Liu, Yetong Feng, Chao Dong, Dandan Yang, Bo Li, Xin Chen, Zhongjun Zhang, Yi Wang, Yulai Zhou, Lei Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0ab78a36db30493d9ac12a8a36e98e3a
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spelling	oai:doaj.org-article:0ab78a36db30493d9ac12a8a36e98e3a2021-11-18T08:19:34ZAdministration of BMSCs with muscone in rats with gentamicin-induced AKI improves their therapeutic efficacy.1932-620310.1371/journal.pone.0097123https://doaj.org/article/0ab78a36db30493d9ac12a8a36e98e3a2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24824427/?tool=EBIhttps://doaj.org/toc/1932-6203The therapeutic action of bone marrow-derived mesenchymal stem cells (BMSCs) in acute kidney injury (AKI) has been reported by several groups. However, recent studies indicated that BMSCs homed to kidney tissues at very low levels after transplantation. The lack of specific homing of exogenously infused cells limited the effective implementation of BMSC-based therapies. In this study, we provided evidence that the administration of BMSCs combined with muscone in rats with gentamicin-induced AKI intravenously, was a feasible strategy to drive BMSCs to damaged tissues and improve the BMSC-based therapeutic effect. The effect of muscone on BMSC bioactivity was analyzed in vitro and in vivo. The results indicated that muscone could promote BMSC migration and proliferation. Some secretory capacity of BMSC still could be improved in some degree. The BMSC-based therapeutic action was ameliorated by promoting the recovery of biochemical variables in urine or blood, as well as the inhibition of cell apoptosis and inflammation. In addition, the up-regulation of CXCR4 and CXCR7 expression in BMSCs could be the possible mechanism of muscone amelioration. Thus, our study indicated that enhancement of BMSCs bioactivities with muscone could increase the BMSC therapeutic potential and further developed a new therapeutic strategy for the treatment of AKI.Pengfei LiuYetong FengChao DongDandan YangBo LiXin ChenZhongjun ZhangYi WangYulai ZhouLei ZhaoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e97123 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pengfei Liu Yetong Feng Chao Dong Dandan Yang Bo Li Xin Chen Zhongjun Zhang Yi Wang Yulai Zhou Lei Zhao Administration of BMSCs with muscone in rats with gentamicin-induced AKI improves their therapeutic efficacy.
description	The therapeutic action of bone marrow-derived mesenchymal stem cells (BMSCs) in acute kidney injury (AKI) has been reported by several groups. However, recent studies indicated that BMSCs homed to kidney tissues at very low levels after transplantation. The lack of specific homing of exogenously infused cells limited the effective implementation of BMSC-based therapies. In this study, we provided evidence that the administration of BMSCs combined with muscone in rats with gentamicin-induced AKI intravenously, was a feasible strategy to drive BMSCs to damaged tissues and improve the BMSC-based therapeutic effect. The effect of muscone on BMSC bioactivity was analyzed in vitro and in vivo. The results indicated that muscone could promote BMSC migration and proliferation. Some secretory capacity of BMSC still could be improved in some degree. The BMSC-based therapeutic action was ameliorated by promoting the recovery of biochemical variables in urine or blood, as well as the inhibition of cell apoptosis and inflammation. In addition, the up-regulation of CXCR4 and CXCR7 expression in BMSCs could be the possible mechanism of muscone amelioration. Thus, our study indicated that enhancement of BMSCs bioactivities with muscone could increase the BMSC therapeutic potential and further developed a new therapeutic strategy for the treatment of AKI.
format	article
author	Pengfei Liu Yetong Feng Chao Dong Dandan Yang Bo Li Xin Chen Zhongjun Zhang Yi Wang Yulai Zhou Lei Zhao
author_facet	Pengfei Liu Yetong Feng Chao Dong Dandan Yang Bo Li Xin Chen Zhongjun Zhang Yi Wang Yulai Zhou Lei Zhao
author_sort	Pengfei Liu
title	Administration of BMSCs with muscone in rats with gentamicin-induced AKI improves their therapeutic efficacy.
title_short	Administration of BMSCs with muscone in rats with gentamicin-induced AKI improves their therapeutic efficacy.
title_full	Administration of BMSCs with muscone in rats with gentamicin-induced AKI improves their therapeutic efficacy.
title_fullStr	Administration of BMSCs with muscone in rats with gentamicin-induced AKI improves their therapeutic efficacy.
title_full_unstemmed	Administration of BMSCs with muscone in rats with gentamicin-induced AKI improves their therapeutic efficacy.
title_sort	administration of bmscs with muscone in rats with gentamicin-induced aki improves their therapeutic efficacy.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/0ab78a36db30493d9ac12a8a36e98e3a
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Administration of BMSCs with muscone in rats with gentamicin-induced AKI improves their therapeutic efficacy.

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